Abstract：
BACKGROUND:For patients with adult spinal deformity (ASD), surgical treatment may improve their health-related quality of life. This study investigates when the greatest improvement in outcomes occurs and whether incremental improvements in patient-reported outcomes during the first postoperative year predict outcomes at 3 years. METHODS:Using a multicenter registry, we identified 84 adults with ASD treated surgically from 2008 to 2012 with complete 3-year follow-up. Pairwise t tests and multivariate regression were used for analysis. Significance was set at P < 0.01. RESULTS:Mean Oswestry Disability Index (ODI) and Scoliosis Research Society-22r total (SRS-22r) scores improved by 13 and 0.8 points, respectively, from preoperatively to 3 years (both P < 0.001). From preoperatively to 6 weeks postoperatively, ODI scores worsened by 5 points (P = 0.049) and SRS-22r scores improved by 0.3 points (P < 0.001). Between 6 weeks and 1 year, ODI and SRS-22r scores improved by 19 and 0.5 points, respectively (both P < 0.001). Incremental improvements during the first postoperative year predicted 3-year outcomes in ODI and SRS-22r scores (adjusted R2 = 0.52 and 0.42, respectively). There were no significant differences in the measured or predicted 3-year ODI (P = 0.991) or SRS-22r scores (P = 0.986). CONCLUSIONS:In surgically treated patients with ASD, the greatest improvements in outcomes occurred between 6 weeks and 1 year postoperatively. A model with incremental improvements from baseline to 6 weeks and from 6 weeks to 1 year can be used to predict ODI and SRS-22r scores at 3 years.
journal_name
World Neurosurgjournal_title
World neurosurgeryauthors
Jain A,Kebaish KM,Sciubba DM,Hassanzadeh H,Scheer JK,Neuman BJ,Lafage V,Bess S,Protopsaltis TS,Burton DC,Smith JS,Shaffrey CI,Hostin RA,Ames CP,International Spine Study Group.doi
10.1016/j.wneu.2017.03.003subject
Has Abstractpub_date
2017-06-01 00:00:00pages
258-262eissn
1878-8750issn
1878-8769pii
S1878-8750(17)30315-7journal_volume
102pub_type
杂志文章,多中心研究abstract：OBJECTIVE:Quantitative measurements of intracranial vessel walls are reliable in 3-T high-resolution magnetic resonance imaging (HR-MRI). However, few reports have assessed the arterial wall after endovascular treatment (EVT) by 3-T HR-MRI. This study aimed to quantitatively analyze vessel walls in vertebrobasilar arte...
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