Disruption in bone marrow fat may attenuate testosterone action on muscle size after spinal cord injury: a case report.

Abstract:

BACKGROUND:Mesenchymal stem cells can be differentiated into muscle satellite cells. Testosterone replacement therapy (TRT) promotes the differentiation of satellite cells into muscle cells. CASE REPORT:A 31-year-old male with a T4 complete chronic spinal cord injury (SCI) had fixation for a mid-shaft fracture of the left femur. The participant received transdermal testosterone patches (4 mg/day) daily for 16 weeks. Skeletal muscle and yellow bone marrow adiposity cross-sectional areas (CSAs) of both thighs were measured using magnetic resonance imaging. CLINICAL REHABILITATION IMPACT:The yellow bone marrow CSA was 67-69% lower in the left femur compared to the right femur. Following intervention, a discrepancy was noted between the whole skeletal muscle CSAs of the right (+13%) and left (+6%) thighs. The right knee extensor CSA increased by 7% with no changes in the left CSA. Disruption in bone marrow fat may attenuate the systemic effects of TRT on muscle size.

journal_name

Eur J Phys Rehabil Med

authors

Gorgey AS,Moore PD,Wade RC,Gill RS,Lavis T,Adler RA

doi

10.23736/S1973-9087.17.04452-5

subject

Has Abstract

pub_date

2017-08-01 00:00:00

pages

625-629

issue

4

eissn

1973-9087

issn

1973-9095

pii

S1973-9087.17.04452-5

journal_volume

53

pub_type

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