当前位置： SCI文献检索 > European Journal of Physical and Rehabilitation Medicine期刊下所有文献 > Safety and efficacy of incobotulinum toxin type A (NT 201-Xeomin) for the treatment of post-stroke lower limb spasticity: a prospective open-label study.

Safety and efficacy of incobotulinum toxin type A (NT 201-Xeomin) for the treatment of post-stroke lower limb spasticity: a prospective open-label study.

Abstract：

BACKGROUND:In recent years, NT 201, a new botulinum toxin type A (BTX-A) free of complexing proteins, has been used for treating several movement disorders, showing safety and efficacy in upper limb spasticity. AIM:To assess the safety and evaluate the effects of BTX-A NT 201 free from complexing proteins for the treatment of post-stroke lower limb spasticity evaluating spasticity grade, passive ankle dorsi-flexion motion, and muscle's spasms, as well as its efficacy and rate of satisfaction for patients and for the physicians. DESIGN:Prospective open-label study. POPULATION:Patients (71) with post-stroke lower limb spasticity at least 5 months by the event. METHODS:Intramuscular injections of BTX-A NT 201 in soleus, medial, and lateral gastrocnemius with a maximum total dose of 180 U. Each patients was assessed at baseline, 30, and 90 days after treatment using Modified Ashworth Scale, Spasm Frequency Scale, evaluating passive ankle dorsi-flexion motion, and the rate of satisfaction for patients and investigators. RESULTS:Patients treated with BTX-A NT 201 reported a statistically significant reduction in muscle tone and spasms daily increasing passive ankle dorsi-flexion at 30 days, persisting also at 90 days of follow-up. CONCLUSION:BTX-A NT 201 for the treatment of post-stroke lower limb spasticity was safe and efficacious reducing muscle tone and spasms, and improving passive ankle dorsi-flexion movement. CLINICAL REHABILITATION IMPACT:These results confirmed the safety and effectiveness of a new type of BTX-A, with low immunogenity, useful to improve rehabilitative treatment of post-stroke lower limb spasticity.

journal_name

Eur J Phys Rehabil Med

journal_title

European journal of physical and rehabilitation medicine

authors

Santamato A,Micello MF,Panza F,Fortunato F,Pilotto A,Giustini A,Testa A,Fiore P,Ranieri M,Spidalieri R

subject

Has Abstract

pub_date

2013-08-01 00:00:00

pages

483-9

issue

4

eissn

1973-9087

issn

1973-9095

pii

R33132962

journal_volume

49

pub_type

杂志文章

相关文献

European Journal of Physical and Rehabilitation Medicine文献大全
  • The role of psychological well‑being in multiple sclerosis rehabilitation.

    abstract：BACKGROUND:In patients affected by multiple sclerosis (MS) the disabilities increase during the progression of the disease, with a negative impact on quality of life. Rehabilitation improves motor performances, but remains unclear the role of psychological variables on motor recovery. AIM:The aim of this study was to ...

    journal_title：European journal of physical and rehabilitation medicine

    pub_type： 杂志文章

    doi：10.23736/S1973-9087.16.04158-7

    authors： Fanciullacci C,Straudi S,Basaglia N,Chisari C

    更新日期：2017-02-01 00:00:00

  • Determinants of disability in chronic musculoskeletal health conditions: a literature review.

    abstract：:Knowledge of the determinants of disability in musculoskeletal conditions (MSC) is critical for reducing their burden. No epidemiologic studies from a truly comprehensive perspective consider environmental factors (EF) and personal factors (PF) as determinants of disability. However, one can identify candidate EF from...

    journal_title：European journal of physical and rehabilitation medicine

    pub_type： 杂志文章,评审

    doi：

    authors： Weigl M,Cieza A,Cantista P,Reinhardt JD,Stucki G

    更新日期：2008-03-01 00:00:00

  • Functional living skills assessment: a standardized measure of high-order activities of daily living in patients with dementia.

    abstract：AIM:Performance measures are tools aimed to directly evaluate social function in older adults. The authors present the standardization of a new direct performance measure for patients with dementia, the functional living skills assessment (FLSA). METHODS:FLSA was conceived to detect functional impairment in very mild ...

    journal_title：European journal of physical and rehabilitation medicine

    pub_type： 杂志文章

    doi：

    authors： Farina E,Fioravanti R,Pignatti R,Alberoni M,Mantovani F,Manzoni G,Chiavari L,Imbornone E,Villanelli F,Nemni R

    更新日期：2010-03-01 00:00:00

  • Focal vibration in neurorehabilitation.

    abstract：:During the last decade, many studies have been carried out to understand the effects of focal vibratory stimuli at various levels of the central nervous system and to study pathophysiological mechanisms of neurological disorders as well as the therapeutic effects of focal vibration in neurorehabilitation. This review ...

    journal_title：European journal of physical and rehabilitation medicine

    pub_type： 杂志文章,评审

    doi：

    authors： Murillo N,Valls-Sole J,Vidal J,Opisso E,Medina J,Kumru H

    更新日期：2014-04-01 00:00:00

  • Comparison between EQ-5D-5L and PROMIS-10 to evaluate health-related quality of life 3 months after stroke: a cross-sectional multicenter study.

    abstract：BACKGROUND:Although the use of patient-reported outcome measures to assess Health-Related Quality of Life (HRQoL) has been advocated, it is still open to debate which patient-reported outcome measure should be preferred to evaluate HRQoL after stroke. AIM:To compare the measurement properties (including concurrent val...

    journal_title：European journal of physical and rehabilitation medicine

    pub_type： 杂志文章

    doi：10.23736/S1973-9087.21.06335-8

    authors： de Graaf JA,Visser-Meily JM,Schepers VP,Baars A,Kappelle LJ,Passier PE,Wermer MJ,de Wit DC,Post MW

    更新日期：2021-01-15 00:00:00

  • Rehabilitation after total hip arthroplasty: a systematic review of controlled trials on physical exercise programs.

    abstract：:Total hip arthroplasty (THA) has revolutionized the care of patients with end-stage joint disease, leading to pain relief, functional recovery, and substantial improvement in quality of life. However, long-term studies indicate persistence of impairment and functional limitation after THA, and the optimal rehabilitati...

    journal_title：European journal of physical and rehabilitation medicine

    pub_type： 杂志文章,评审

    doi：

    authors： Di Monaco M,Vallero F,Tappero R,Cavanna A

    更新日期：2009-09-01 00:00:00

  • Development of a new patient-reported outcome measure assessing activities and participation in people with lumbar spinal stenosis: the cochin spinal stenosis 19-item questionnaire.

    abstract：BACKGROUND:Lumbar spinal stenosis (LSS) is the leading cause of spinal surgery in people over 65-years old. In people with LSS, generic self-administered questionnaires are the most commonly used PROs to assess health-related quality of life, global activity limitation, and low back pain-located activity limitation. A...

    journal_title：European journal of physical and rehabilitation medicine

    pub_type： 杂志文章

    doi：10.23736/S1973-9087.20.06189-4

    authors： Masi C,Couraud G,Daste C,Jouffriault J,Poiraudeau S,Lefevre-Colau MM,Rannou F,Nguyen C

    更新日期：2020-10-28 00:00:00

  • Trunk motion analysis: a systematic review from a clinical and methodological perspective.

    abstract：INTRODUCTION:This systematic literature review aims to check the current state of affairs of non-gait-related optoelectronic trunk movement analysis; results have been analyzed from a clinical and a methodological perspective. EVIDENCE ACQUISITION:Extensive research was performed on all papers published until December...

    journal_title：European journal of physical and rehabilitation medicine

    pub_type： 杂志文章,评审

    doi：

    authors： Negrini S,Piovanelli B,Amici C,Cappellini V,Bovi G,Ferrarin M,Zaina F,Borboni A

    更新日期：2016-08-01 00:00:00

  • Effects of whole body cryo-chamber therapy on pain in patients with chronic low back pain: a prospective double blind randomised controlled trial.

    abstract：BACKGROUND:It is believed that treatment with low temperature can reduce pain perception in chronic pain patients, including chronic low back pain patients. AIM:To evaluate the effects of a two-week repeated intervention of -67 °C cryo-chamber in patients with chronic low back pain. DESIGN:A prospective randomized do...

    journal_title：European journal of physical and rehabilitation medicine

    pub_type： 杂志文章,随机对照试验

    doi：

    authors： Nugraha B,Günther JT,Rawert H,Siegert R,Gutenbrunner C

    更新日期：2015-04-01 00:00:00

  • Role of spiritual beliefs on disability and health-related quality of life in acute inpatient rehabilitation unit.

    abstract：BACKGROUND:The influence of spirituality and religious beliefs on health-related quality of life and disability in the rehabilitation field is discussed in literature. AIM:To describe the role of spiritual belief on functional recovery and health-related quality of life in acute inpatient rehabilitation ward. DESIGN:...

    journal_title：European journal of physical and rehabilitation medicine

    pub_type： 杂志文章

    doi：

    authors： Maggi L,Ferrara PE,Aprile I,Ronconi G,Specchia A,Nigito C,Amabile E,Rabini A,Piazzini DB,Bertolini C

    更新日期：2012-09-01 00:00:00

  • Physical medicine respiratory muscle aids to avert respiratory complications of pediatric chest wall and vertebral deformity and muscle dysfunction.

    abstract：:The purpose of this article was to describe the use of noninvasive inspiratory and expiratory muscle aids to prevent chest wall deformities including pectus excavatum, to prevent respiratory complications of vertebral surgery, to prevent acute and long-term ventilatory insufficiency and failure in children with paraly...

    journal_title：European journal of physical and rehabilitation medicine

    pub_type： 杂志文章,评审

    doi：

    authors： Ishikawa Y,Bach JR

    更新日期：2010-12-01 00:00:00

  • Acute hemodynamic and electrocardiographic responses to a session of inspiratory muscle training in cardiopulmonary rehabilitation.

    abstract：BACKGROUND:Inspiratory muscle training (IMT) has been shown to generate significant benefits in different clinical conditions; however, there is scarce information regarding acute clinical and hemodynamic effects. AIM:The aim of this study was to evaluate clinical, hemodynamic and electrocardiographic responses during...

    journal_title：European journal of physical and rehabilitation medicine

    pub_type： 杂志文章

    doi：

    authors： Ramos PS,Da Costa Da Silva B,Gomes Da Silva LO,Araújo CG

    更新日期：2015-12-01 00:00:00

  • A (single case) rehabilitation program based on cueing for freezing of speech.

    abstract：BACKGROUND:Freezing of speech (FoS) and other repetitive speech behaviours can frequently occur in parkinsonian syndromes, worsening the efficacy of language functioning, hampering social interactions, and thus reducing quality of life. Pharmacological treatment are ineffective and other interventions have not specific...

    journal_title：European journal of physical and rehabilitation medicine

    pub_type： 杂志文章

    doi：

    authors： Erro R,Tedeschi MR,Vitale C,Buonocore S,Orefice G

    更新日期：2014-10-01 00:00:00

  • Short- and long-term effects of intensive training and motivational programme for continued physical activity in patients with inflammatory rheumatic diseases.

    abstract：BACKGROUND:Despite the positive health effects of (intensive) exercise in patients with inflammatory rheumatic diseases, they are very often inactive. Motivational exercise interventions in other patient samples have shown good effects in promoting exercise behaviours. AIM:To evaluate the short- and long-term effects ...

    journal_title：European journal of physical and rehabilitation medicine

    pub_type： 杂志文章

    doi：

    authors： Mattukat K,Rennert D,Brandes I,Ehlebracht-König I,Kluge K,Mau W

    更新日期：2014-08-01 00:00:00

  • Combined effects of robot‑assisted gait training and botulinum toxin type A on spastic equinus foot in patients with chronic stroke: a pilot, single blind, randomized controlled trial.

    abstract：BACKGROUND:Despite the growing evidence about the use of robotic gait training in neurorehabilitation, there is a scant literature about the combined effects of this innovative technological approach and a first‑line treatment for focal spasticity as botulinum toxin type A. In particular, to the best of our knowledge, ...

    journal_title：European journal of physical and rehabilitation medicine

    pub_type： 杂志文章,随机对照试验

    doi：

    authors： Picelli A,Bacciga M,Melotti C,LA Marchina E,Verzini E,Ferrari F,Pontillo A,Corradi J,Tamburin S,Saltuari L,Corradini C,Waldner A,Smania N

    更新日期：2016-12-01 00:00:00

  • The predictive value of subsets of the Örebro Musculoskeletal Pain Screening Questionnaire for return to work in chronic low back pain.

    abstract：BACKGROUND:Studies have shown that positive recovery expectations are associated with positive health outcomes in patients with chronic low back pain (CLBP) such as return to work (RTW) and the time to RTW. AIM:To compare the predictive value for RTW in CLBP using different subsets of the Örebro Musculoskeletal Pain S...

    journal_title：European journal of physical and rehabilitation medicine

    pub_type： 杂志文章

    doi：10.23736/S1973-9087.17.04398-2

    authors： Opsommer E,Rivier G,Crombez G,Hilfiker R

    更新日期：2017-06-01 00:00:00

  • Evidence-based position paper on Physical and Rehabilitation Medicine (PRM) professional practice for people with respiratory conditions. The European PRM position (UEMS PRM Section).

    abstract：:Chronic respiratory conditions are among the top causes of death and disability. The aim of the paper was to improve Physical and Rehabilitation Medicine (PRM) physicians' professional practice for people with chronic respiratory conditions in order to promote their functioning and to reduce activity limitations and/o...

    journal_title：European journal of physical and rehabilitation medicine

    pub_type： 杂志文章,评审

    doi：10.23736/S1973-9087.18.05309-1

    authors： Oral A,Juocevicius A,Lukmann A,Takáč P,Tederko P,Hāznere I,Aguiar-Branco C,Lazovic M,Negrini S,Varela Donoso E,Christodoulou N

    更新日期：2018-08-01 00:00:00

  • Reliability of a functional test battery evaluating functionality, proprioception, and strength in recreational athletes with functional ankle instability.

    abstract：AIM:In contrast to the single evaluation methods used in the past, the combination of multiple tests allows one to obtain a global assessment of the ankle joint. The aim of this study was to determine the reliability of the different tests in a functional test battery. METHODS:Twenty-four male recreational athletes wi...

    journal_title：European journal of physical and rehabilitation medicine

    pub_type： 杂志文章

    doi：

    authors： Sekir U,Yildiz Y,Hazneci B,Ors F,Saka T,Aydin T

    更新日期：2008-12-01 00:00:00

  • Cochrane Rehabilitation blogshots: a modern method to spread Cochrane Evidence.

    abstract：:The translation of scientific knowledge into clinical practice is still not consistently achieved and the Cochrane Knowledge Translation (KT) Strategy, has been developed in response to this issue, as key step in moving from knowledge to action. "Blogshots" are a new means of presenting evidence in a way that can be e...

    journal_title：European journal of physical and rehabilitation medicine

    pub_type： 杂志文章

    doi：10.23736/S1973-9087.18.05313-3

    authors： Arienti C,Gimigliano F,Ryan-Vig S,Kiekens C,Negrini S

    更新日期：2018-06-01 00:00:00

  • Are the spatio-temporal parameters of gait capable of distinguishing a faller from a non-faller elderly?

    abstract：:Fall is a common and a major cause of injuries. It is important to find elderlies who are prone to falls. The majority of serious falls occur during walking among the older adults. Analyzing the spatio-temporal parameters of walking is an easy way of assessment in the clinical setting, but is it capable of distinguish...

    journal_title：European journal of physical and rehabilitation medicine

    pub_type： 杂志文章,评审

    doi：

    authors： Mortaza N,Abu Osman NA,Mehdikhani N

    更新日期：2014-12-01 00:00:00

  • Involvement of swallowing therapy is associated with improved long-term survival in patients with post-stroke dysphagia.

    abstract：BACKGROUND:The effects of swallowing therapy (ST) on long-term clinical outcomes in patients with post-stroke dysphagia (PSD) remain unclear. AIM:This study explores the effect of ST, initiated within 6 months of the stroke onset, on long-term pneumonia-free and overall survival rates in PSD patients. DESIGN:Retrospe...

    journal_title：European journal of physical and rehabilitation medicine

    pub_type： 杂志文章

    doi：10.23736/S1973-9087.19.05893-3

    authors： Lo YK,Fu TC,Chen CP,Yuan SS,Hsu CC

    更新日期：2019-12-01 00:00:00

  • The term diplegia should be enhanced. Part II: contribution to validation of the new rehabilitation oriented classification.

    abstract：:Recent proposals of classification for cerebral palsy (CP), mainly revised for epidemiological purposes, suggest to abandon the use of the term diplegia. Conversely, in this paper data are presented to support the proposal to maintain the distinction between spastic tetraplegia and diplegia, and to subdivide this latt...

    journal_title：European journal of physical and rehabilitation medicine

    pub_type： 杂志文章

    doi：

    authors： Cioni G,Lodesani M,Pascale R,Coluccini M,Sassi S,Paolicelli PB,Perazza S,Ferrari A

    更新日期：2008-06-01 00:00:00

  • Conservative management of adult neurogenic lower urinary tract dysfunction.

    abstract：:Neurogenic lower urinary tract dysfunction (NLTUD) is commonly encountered in neuro-rehabilitation settings and is caused by a variety of pathologies. The management of spinal cord injury (SCI) has been the model of reference for the approach to NLTUD due to many other diseases of the central and peripheral nervous sy...

    journal_title：European journal of physical and rehabilitation medicine

    pub_type： 杂志文章

    doi：10.23736/S1973-9087.17.04980-2

    authors： DI Benedetto P,Finazzi-Agrò E

    更新日期：2017-12-01 00:00:00

  • Normalization of Functional Independence Measure variation improves assessment of stroke rehabilitation outcome.

    abstract：BACKGROUND:Assessment of rehabilitation outcome is based on measuring the change in Functional Independence Measure (FIMTM) score between the start and end of rehabilitation. However, the raw FIMTM score gain is subject to a ceiling effect. Proposed solutions to this problem have incongruities that limit their use. AI...

    journal_title：European journal of physical and rehabilitation medicine

    pub_type： 杂志文章

    doi：

    authors： Lanzillo B,Matarazzo G,Calabrese C,Vitale DF

    更新日期：2015-10-01 00:00:00

  • Walking capacity and ability are more impaired in progressive compared to relapsing type of multiple sclerosis.

    abstract：BACKGROUND:Patients with progressive multiple sclerosis (MS) have been attributed greater walking disability than relapsing-remitting MS (RRMS) patients but quantitative data on walking speed and ability are lacking. AIM:To investigate the impact of type of MS on severity of reduced walking ability and capacity taking...

    journal_title：European journal of physical and rehabilitation medicine

    pub_type： 杂志文章,多中心研究

    doi：

    authors： Feys P,Bibby BM,Baert I,Dalgas U

    更新日期：2015-04-01 00:00:00

  • The Italian National Registry of severe acquired brain injury: epidemiological, clinical and functional data of 1469 patients.

    abstract：BACKGROUND:The lack of knowledge about epidemiological and clinical data of patients with Acquired Brain Injury (ABI) admitted to Rehabilitation facilities in Italy led to the creation, in June 2008, of a data collection on-line registry. AIM:To collect epidemiological and clinical data and to evaluate functional outc...

    journal_title：European journal of physical and rehabilitation medicine

    pub_type： 杂志文章

    doi：

    authors： Avesani R,Roncari L,Khansefid M,Formisano R,Boldrini P,Zampolini M,Ferro S,De Tanti A,Dambruoso F

    更新日期：2013-10-01 00:00:00

  • Multiple sclerosis patients' experiences in relation to the impact of the kinect virtual home-exercise programme: a qualitative study.

    abstract：BACKGROUND:Neurorehabilitation programs are among the most popular therapies aimed at reducing the disabilities that result from multiple sclerosis. Video games have recently gained importance in the rehabilitation of patients with motor neurological dysfunctions. Currently, the studies describing the perspective of pa...

    journal_title：European journal of physical and rehabilitation medicine

    pub_type： 杂志文章

    doi：

    authors： Palacios-Ceña D,Ortiz-Gutierrez RM,Buesa-Estellez A,Galán-Del-Río F,Cachon Perez JM,Martínez-Piedrola R,Velarde-Garcia JF,Cano-DE-LA-Cuerda R

    更新日期：2016-06-01 00:00:00

  • EJPRM systematic continuous update on Cochrane reviews in rehabilitation: news from September 2010 to January 2011.

    abstract：AIM:Since 2007 we focused our attention as EJPRM to the best available clinical evidence as offered by the Cochrane Collaboration. Due to the absence of a specific Rehabilitation Group (only a Field exists), reviews of PRM interest are in different groups and not easy to find. Consequently, the EJPRM offer the service ...

    journal_title：European journal of physical and rehabilitation medicine

    pub_type： 杂志文章

    doi：

    authors： Zaina F,Negrini S

    更新日期：2011-03-01 00:00:00

  • White Book on Physical and Rehabilitation Medicine (PRM) in Europe. Chapter 9. Education and continuous professional development: shaping the future of PRM.

    abstract：:In the context of the White Book of Physical and Rehabilitation Medicine (PRM), this paper deals with the education of PRM physicians in Europe. To acquire the wide field of competence needed, specialists in Physical and Rehabilitation Medicine have to undergo a well organised and appropriately structured training of ...

    journal_title：European journal of physical and rehabilitation medicine

    pub_type： 杂志文章,评审

    doi：10.23736/S1973-9087.18.05153-5

    authors： European Physical and Rehabilitation Medicine Bodies Alliance.

    更新日期：2018-04-01 00:00:00

  • Pathways to certifications in physical medicine and rehabilitation in the United States: past, present, and future.

    abstract：:This article describes the certification pathways for Physiatrists in the United States, reviews the licensure, certification and accreditation pathways for rehabilitation facilities in the United States, examines the evolving models of health care in the United States, evaluates the impact of health care reform withi...

    journal_title：European journal of physical and rehabilitation medicine

    pub_type： 杂志文章

    doi：

    authors： Wu SS,Welch DG,Hoppe KM,Weinstein SM

    更新日期：2013-06-01 00:00:00