当前位置： SCI文献检索 > JOURNAL OF PEDIATRIC SURGERY期刊下所有文献 > Stem cells and necrotizing enterocolitis: A direct comparison of the efficacy of multiple types of stem cells.

Stem cells and necrotizing enterocolitis: A direct comparison of the efficacy of multiple types of stem cells.

Abstract：

PURPOSE:Necrotizing enterocolitis (NEC) is a leading cause of gastrointestinal morbidity and mortality in premature infants. While studies have shown potential for stem cell (SC) therapy in experimental NEC, no study has compared different SC side-by-side. Our purpose was to determine whether one type of SC may more effectively treat NEC than others. METHODS:Four SC were compared: (1) amniotic fluid-derived mesenchymal SC (AF-MSC); (2) amniotic fluid-derived neural SC (AF-NSC); (3) bone marrow-derived mesenchymal SC (BM-MSC); and (4) neonatal enteric neural SC (E-NSC). Using an established rat model of NEC, pups delivered prematurely received an intraperitoneal injection of SC. Control pups were injected with PBS. Additional controls were breast-fed by surrogates and not subjected to experimental NEC. Intestinal tissue was graded histologically. RESULTS:NEC incidence was: PBS, 61.3%; breast-fed unstressed, 0%; AF-MSC, 19.1%; BM-MSC, 22.9%; AF-NSC, 18.9%; E-NSC 22.2%. All groups demonstrated statistical significance (p<0.05) compared to controls, and there was no difference between SC groups. CONCLUSION:All four SC groups reduced the incidence and severity of experimental NEC equivalently. AF-MSC may be preferable because of availability of AF at delivery and ease of expansion, increasing potential for clinical translation. LEVEL OF EVIDENCE:V (Animal study).

journal_name

J Pediatr Surg

journal_title

Journal of pediatric surgery

authors

McCulloh CJ,Olson JK,Zhou Y,Wang Y,Besner GE

doi

10.1016/j.jpedsurg.2017.03.028

subject

Has Abstract

pub_date

2017-06-01 00:00:00

pages

999-1005

issue

6

eissn

0022-3468

issn

1531-5037

pii

S0022-3468(17)30177-X

journal_volume

52

pub_type

杂志文章

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