PR55α Subunit of Protein Phosphatase 2A Supports the Tumorigenic and Metastatic Potential of Pancreatic Cancer Cells by Sustaining Hyperactive Oncogenic Signaling.

abstract：:The relevance of cysteine metabolism in cancer has gained considerable interest in recent years, largely focusing on its role in generating the antioxidant glutathione. Through metabolomic profiling using a combination of high-throughput liquid and gas chromatography-based mass spectrometry on a total of 69 patient-de...

journal_title：Cancer research

authors： Prabhu A,Sarcar B,Kahali S,Yuan Z,Johnson JJ,Adam KP,Kensicki E,Chinnaiyan P

更新日期：2014-02-01 00:00:00

abstract：:TGF-β has limited effects on ovarian cancer cells, but its contributions to ovarian tumor growth might be mediated through elements of the tumor microenvironment. In the present study, we tested the hypothesis that TGF modulates ovarian cancer progression by modulating the contribution of cancer-associated fibroblasts...

journal_title：Cancer research

authors： Yeung TL,Leung CS,Wong KK,Samimi G,Thompson MS,Liu J,Zaid TM,Ghosh S,Birrer MJ,Mok SC

更新日期：2013-08-15 00:00:00

abstract：:Phospholipase D (PLD) has emerged as a critical regulator of cell proliferation and survival signaling. We show for the first time that elevated expression of PLD isozymes attenuates expression of the tumor suppressors early growth response-1 (Egr-1) and the phosphatase and tensin homologue deleted on chromosome 10 (P...

journal_title：Cancer research

authors： Kim J,Lee YH,Kwon TK,Chang JS,Chung KC,Min DS

更新日期：2006-01-15 00:00:00

abstract：:Head and neck squamous cell carcinomas (HNSCC) often metastasize to locoregional lymph nodes, and lymph node involvement represents one of the most important prognostic factors of poor clinical outcome. HNSCCs are remarkably lymphangiogenic and represent a clear example of a cancer that utilizes the lymphatic vasculat...

journal_title：Cancer research

authors： Doçi CL,Mikelis CM,Lionakis MS,Molinolo AA,Gutkind JS

更新日期：2015-07-15 00:00:00

abstract：:In order to elucidate the response of mitochondria to the increase in cellular energy demand after hepatectomy, we have examined the effects of partial hepatectomy and hepatic artery ligation on the energy-transducing system of rat liver mitochondria. Specific content of DNA in the mitochondria increased on the first ...

journal_title：Cancer research

authors： Nagino M,Tanaka M,Nishikimi M,Nimura Y,Kubota H,Kanai M,Kato T,Ozawa T

更新日期：1989-09-01 00:00:00

abstract：:The spontaneous development of juvenile-onset ovarian granulosa cell tumors in mice of the SWXJ-9 recombinant inbred strain is a model for juvenile-type granulosa cell tumors that appear in very young girls. To expedite gene discovery in this mouse model of childhood cancer, we did a gene mapping study with the SWXJ-9...

journal_title：Cancer research

authors： Dorward AM,Shultz KL,Horton LG,Li R,Churchill GA,Beamer WG

更新日期：2005-02-15 00:00:00

abstract：:Adenylate cyclase responses to pituitary hormones including adrenocorticotropic hormone (ACTH), biogenetic amines, prostaglandin E1 (PGE1), angiotensin II, and glucagon were evaluated in adrenocortical tumors and hyperplastic adrenal tissues, obtained from patients with Cushing's syndrome at surgery, and in normal adr...

journal_title：Cancer research

authors： Matsukura S,Kakita T,Sueoka S,Yoshimi H,Hirata Y,Yokota M,Fujita T

更新日期：1980-10-01 00:00:00

abstract：:The antitumor activity of combination therapy with recombinant tumor necrosis-alpha (rhTNF-alpha) and recombinant interleukin-2 (rhIL-2) was assessed against established immunogenic (MCA-106) and nonimmunogenic (MCA-102) sarcomas at both s.c. and visceral (hepatic) sites. C57BL/6 (B6) mice were treated with a single i...

journal_title：Cancer research

authors： McIntosh JK,Mulé JJ,Merino MJ,Rosenberg SA

更新日期：1988-07-15 00:00:00

abstract：:alphaVbeta3 integrin complexes are overexpressed in the growing, invading margins of human glioblastoma multiforme (GBM) and in the GBM vasculature, suggesting a key role for alphaVbeta3 in GBM growth and invasion. The function of alphaVbeta3 complexes in tumor formation, however, has been challenged by studies showin...

journal_title：Cancer research

authors： Kanamori M,Vanden Berg SR,Bergers G,Berger MS,Pieper RO

更新日期：2004-04-15 00:00:00

abstract：:The microbial alkaloid staurosporine is a potent but nonselective inhibitor of protein kinases. The derivative CGP 41251 has been shown to exert a high degree of selectivity for inhibition of protein kinase C activity. Both compounds are powerful inhibitors of proliferation of both normal and transformed cells in vitr...

journal_title：Cancer research

authors： Andrejauskas-Buchdunger E,Regenass U

更新日期：1992-10-01 00:00:00

abstract：:Cells that overexpress high-mobility group A1 (HMGA1) proteins exhibit deficient nucleotide excision repair (NER) after exposure to DNA-damaging agents, a condition ameliorated by artificially lowering intracellular levels of these nonhistone proteins. One possible mechanism for this NER inhibition is down-regulation ...

journal_title：Cancer research

authors： Adair JE,Maloney SC,Dement GA,Wertzler KJ,Smerdon MJ,Reeves R

更新日期：2007-07-01 00:00:00

abstract：:Clinical trials have utilized intermittent diethylstilbestrol diphosphate (DES) therapy in advanced symptomatic prostatic carcinoma to diminish the morbidity of standard endocrine therapy. To determine the effect of intermittent DES administration on the Dunning R3327 rat prostatic adenocarcinoma 60 days following tum...

journal_title：Cancer research

authors： Russo P,Liguori G,Heston WD,Huryk R,Yang CR,Fair WR,Whitmore WF,Herr HW

更新日期：1987-11-15 00:00:00

abstract：:A variety of heterologous mammalian cells were inoculated into nude mice and scored for tumorigenicity. The cells tested were from primary cell cultures, established cell lines of neoplastic origin, established cell lines of nontumor origin, and primary cell cultures transformed by oncogenic viruses. Regardless of the...

journal_title：Cancer research

authors： Stiles CD,Desmond W,Chuman LM,Sato G,Saier MH

更新日期：1976-04-01 00:00:00

abstract：:Tbx3 encodes a transcriptional repressor that is important for diverse patterning events during development, and Tbx3 mutation in humans causes the ulnar-mammary syndrome. Here, we describe the identification of Tbx3 in array-based search for genes downstream Wnt/beta-catenin that are implicated in liver tumorigenesis...

journal_title：Cancer research

authors： Renard CA,Labalette C,Armengol C,Cougot D,Wei Y,Cairo S,Pineau P,Neuveut C,de Reyniès A,Dejean A,Perret C,Buendia MA

更新日期：2007-02-01 00:00:00

abstract：:Our goal is to develop peptide vaccines that stimulate tumor antigen-specific T-cell responses against frequently found cancers. Previous work has shown that to generate effective T-cell responses, peptides have to be administered in combination with strong adjuvants such as Toll-like receptor agonists. However, most ...

journal_title：Cancer research

authors： Nava-Parada P,Forni G,Knutson KL,Pease LR,Celis E

更新日期：2007-02-01 00:00:00

abstract：:A tetracosapeptide (peptide-24) corresponding to the amino-terminal sequence of the carcinoembryonic antigen (CEA) was synthesized and characterized. Antisera were produced to the peptide-24, and a radioimmunoassay was developed utilizing peptide-24 with a tyrosine residue on the amino-terminal end (Tyr-peptide-24). I...

journal_title：Cancer research

authors： Paul D,Flouret G,Tomita JT,Ranney K,Schenck J,Anderson B

更新日期：1981-06-01 00:00:00

abstract：:The characterization of radiation-induced fibrosarcoma cells (RIF-8A) which have been selected for resistance to Photofrin-mediated photodynamic therapy (PDT) is detailed in this report. Morphological and functional assessment of mitochondria in both the resistant RIF-8A and parental RIF-1 cells show distinct differen...

journal_title：Cancer research

authors： Sharkey SM,Wilson BC,Moorehead R,Singh G

更新日期：1993-10-15 00:00:00

abstract：:Targeting the tyrosine kinase activity of Bcr-Abl is an attractive therapeutic strategy in chronic myeloid leukemia (CML) and in Bcr-Abl-positive acute lymphoblastic leukemia. Whereas imatinib, a selective inhibitor of Bcr-Abl tyrosine kinase, is now used in frontline therapy for CML, second-generation inhibitors of B...

journal_title：Cancer research

authors： Mahon FX,Hayette S,Lagarde V,Belloc F,Turcq B,Nicolini F,Belanger C,Manley PW,Leroy C,Etienne G,Roche S,Pasquet JM

更新日期：2008-12-01 00:00:00

abstract：:In ovarian cancer, the immune system fails to eradicate established tumors partly due to the induction of immune tolerance within tumor microenvironment. In this study, we investigated the contribution of plasmacytoid dendritic cells (pDC) in the establishment of immune tolerance in a cohort of 44 ovarian cancer patie...

journal_title：Cancer research

authors： Labidi-Galy SI,Sisirak V,Meeus P,Gobert M,Treilleux I,Bajard A,Combes JD,Faget J,Mithieux F,Cassignol A,Tredan O,Durand I,Ménétrier-Caux C,Caux C,Blay JY,Ray-Coquard I,Bendriss-Vermare N

更新日期：2011-08-15 00:00:00

abstract：:Mucin 1 (MUC1), a bound mucin glycoprotein, is overexpressed and aberrantly glycosylated in >80% of human ductal pancreatic carcinoma. Evidence suggests that MUC1 can be used as a tumor marker and is a potential target for immunotherapy of pancreatic cancer. However, vaccination with MUC1 peptides fails to stimulate t...

journal_title：Cancer research

authors： Deguchi T,Tanemura M,Miyoshi E,Nagano H,Machida T,Ohmura Y,Kobayashi S,Marubashi S,Eguchi H,Takeda Y,Ito T,Mori M,Doki Y,Sawa Y

更新日期：2010-07-01 00:00:00

abstract：:The effect of commercial saccharin preparations on urethan-induced mouse lung tumorigenesis was assessed by gavaging groups of male strain A mice with 1-g/kg doses of each saccharin preparation on a daily basis 5 days/week. Gavage was initiated 1 week before i.p. injection of either a low (0.1 mg/g) or a high (1 mg/g)...

journal_title：Cancer research

authors： Theiss JC,Arnold LJ,Shimkin MB

更新日期：1980-11-01 00:00:00

abstract：:It is widely accepted that a major role of matrix metalloproteinases in the metastatic process is degradation of basement membrane during cancer cell invasion. We tested the hypothesis that the reduction in metastatic potential which has been demonstrated for B16F10 melanoma cells genetically engineered to overexpress...

journal_title：Cancer research

authors： Koop S,Khokha R,Schmidt EE,MacDonald IC,Morris VL,Chambers AF,Groom AC

更新日期：1994-09-01 00:00:00

abstract：:The failure and/or toxicity of conventional therapies for many types of human cancers underscore the need for development of safe and effective alternative treatments. Toward this goal, we describe the direct oncolytic activity of RNA-based vectors derived from poliovirus, termed replicons, which are genetically incap...

journal_title：Cancer research

authors： Ansardi DC,Porter DC,Jackson CA,Gillespie GY,Morrow CD

更新日期：2001-12-01 00:00:00

abstract：:Ovarian and testicular tumors were induced in the offspring (F1 generation) of MRC rats that received single or multiple doses of N-nitrosobis(2-oxopropyl)amine on the 14th, 18th, and/or 20th days of pregnancy. The ovarian tumor incidence was significantly higher (46%) in the F1 generation exposed to the carcinogen a ...

journal_title：Cancer research

authors： Pour PM

更新日期：1986-08-01 00:00:00

abstract：:Fibroblast growth factor receptor 1 (FGFR1) is frequently amplified and highly expressed in lobular carcinomas of the breast. In this report, we evaluated the biological activity of FGFR1 in a wide range of in vitro assays. Conditional activation of FGFR1 in the nontransformed MCF10A human mammary cell line, MCF10A, r...

journal_title：Cancer research

authors： Xian W,Pappas L,Pandya D,Selfors LM,Derksen PW,de Bruin M,Gray NS,Jonkers J,Rosen JM,Brugge JS

更新日期：2009-03-15 00:00:00

abstract：:Previously, we had reported that a single i.p. injection of 15 mg cyclophosphamide (CY) per kg cured most mice bearing large MOPC-315 tumors (20 to 25 mm; Day 12 to Day 16 tumors) but rarely cured mice bearing nonpalpable tumors (Day 4 tumors). Also, mice that were not cured if treated with CY, 15 mg/kg, when they had...

journal_title：Cancer research

authors： Mokyr MB,Hengst JC,Dray S

更新日期：1982-03-01 00:00:00

abstract：:Metabolite profiling using (1)H nuclear magnetic resonance (NMR) spectroscopy was used to investigate the metabolic changes associated with deletion of the gene for the transcriptional coactivator p300 in the human colon carcinoma cell line HCT116. Multivariate statistical methods were used to distinguish between meta...

journal_title：Cancer research

authors： Bundy JG,Iyer NG,Gentile MS,Hu DE,Kettunen M,Maia AT,Thorne NP,Brenton JD,Caldas C,Brindle KM

更新日期：2006-08-01 00:00:00

abstract：:Fluorescent-labeled hormones can be used to study hormone-receptor interactions by means of fluorescence polarization, visualization by fluorescence microscopy, or separation methods, e.g., dextran-coated charcoal. Subcellular fragments, single cells, and tissue preparations are amenable to study; in this work rat ute...

journal_title：Cancer research

authors： Dandliker WB,Brawn RJ,Hsu ML,Brawn PN,Levin J,Meyers CY,Kolb VM

更新日期：1978-11-01 00:00:00

abstract：:Chronic exposure to UV radiation (UVR), especially in the UVA (315-400 nm) and UVB (280-315 nm) spectrum of sunlight, is the major risk factor for the development of nonmelanoma skin cancer. UVR is a complete carcinogen, which both initiates and promotes carcinogenesis. We found that protein kinase C epsilon (PKCepsil...

journal_title：Cancer research

authors： Wheeler DL,Martin KE,Ness KJ,Li Y,Dreckschmidt NE,Wartman M,Ananthaswamy HN,Mitchell DL,Verma AK

更新日期：2004-11-01 00:00:00

abstract：:Consequences of the obesity epidemic on cancer morbidity and mortality are not fully appreciated. Obesity is a risk factor for many cancers, but the mechanisms by which it contributes to cancer development and patient outcome have yet to be fully elucidated. Here, we examined the effects of coculturing human-derived a...

journal_title：Cancer research

authors： Picon-Ruiz M,Pan C,Drews-Elger K,Jang K,Besser AH,Zhao D,Morata-Tarifa C,Kim M,Ince TA,Azzam DJ,Wander SA,Wang B,Ergonul B,Datar RH,Cote RJ,Howard GA,El-Ashry D,Torné-Poyatos P,Marchal JA,Slingerland JM

更新日期：2016-01-15 00:00:00