A Mathematical Model of Countercurrent Exchange of Oxygen Between Paired Arterioles and Venules.

Abstract:

:A mathematical model is formulated for diffusive countercurrent exchange of oxygen between paired arterioles and venules. A closed form solution of the problem is obtained by linearizing the nonlinear oxyhemoglobin dissociation curve at the inlet PO2 in the vessel. The closed form solution is compared with the corresponding numerical solution of the nonlinear problem. Under normal conditions, longitudinal gradients of venular PO2 are found to be small. Examples are presented where the model predicts significant gradients of venular PO2 when the blood flow rate in the venule is several times smaller than that in the arteriole.

journal_name

Math Biosci

journal_title

Mathematical biosciences

authors

Sharan M,Popel AS

doi

10.1016/0025-5564(88)90022-3

subject

Has Abstract

pub_date

1988-09-01 00:00:00

pages

17-34

issue

1

eissn

0025-5564

issn

1879-3134

journal_volume

91

pub_type

杂志文章
  • Spread of excitation in 3-D models of the anisotropic cardiac tissue. III. Effects of ventricular geometry and fiber structure on the potential distribution.

    abstract::In a previous paper we studied the spread of excitation in a simplified model of the left ventricle, affected by fiber structure and obliqueness, curvature of the wall and Purkinje network. In the present paper we investigate the extracellular potential distribution u in the same ventricular model. Given the transmemb...

    journal_title:Mathematical biosciences

    pub_type: 杂志文章

    doi:10.1016/s0025-5564(98)10004-4

    authors: Colli Franzone P,Guerri L,Pennacchio M,Taccardi B

    更新日期:1998-07-01 00:00:00

  • On using Lehmann alternatives with nonresponders.

    abstract::The problem of testing for treatment effect when some subjects in the treatment group may be unaffected by the treatment is considered. A form of the Lehmann alternative suggested by Conover and Salsburg is used that assumes that each control score has the same distribution as the minimum of the known number of respon...

    journal_title:Mathematical biosciences

    pub_type: 杂志文章

    doi:10.1016/0025-5564(92)90052-x

    authors: Razzaghi M,Nanthakumar A

    更新日期:1992-04-01 00:00:00

  • Evaluating spread of invaders from gravity scores--a way of using gravity models in ecology.

    abstract::This study is a theoretical excursion into gravity models and their usability in evaluating importance of spatial structure and population development for the spread of colonizing organisms. A so called "gravity score" for sites is deduced, and such a score could be used for predicting risk of colonization once one si...

    journal_title:Mathematical biosciences

    pub_type: 杂志文章

    doi:10.1016/j.mbs.2009.08.008

    authors: Järemo J

    更新日期:2009-11-01 00:00:00

  • Multi-timescale systems and fast-slow analysis.

    abstract::Mathematical models of biological systems often have components that vary on different timescales. This multi-timescale character can lead to problems when doing computer simulations, which can require a great deal of computer time so that the components that change on the fastest time scale can be resolved. Mathemati...

    journal_title:Mathematical biosciences

    pub_type: 杂志文章

    doi:10.1016/j.mbs.2016.07.003

    authors: Bertram R,Rubin JE

    更新日期:2017-05-01 00:00:00

  • A nonlinear numerical model of percutaneous drug absorption.

    abstract::A nonlinear mathematical model developed by Chandrasekaran et al. is examined to monitor pharmacokinetic profiles in percutaneous drug absorption and is addressed to several associated problems that could occur in the data analysis of in vitro experiments. The formulation of the model gives rise to a nonlinear partial...

    journal_title:Mathematical biosciences

    pub_type: 杂志文章

    doi:10.1016/0025-5564(92)90054-z

    authors: Kubota K,Twizell EH

    更新日期:1992-03-01 00:00:00

  • Stochastic differential equation models for spatially distributed neurons and propagation of chaos for interacting systems.

    abstract::Distribution or nuclear space-valued stochastic differential equations (SDEs) (diffusions as well as discontinuous equations) are discussed as stochastic models for the behavior of voltage potentials of spatially distributed neurons. A propagation of chaos result is obtained for an interacting system of Hilbert space-...

    journal_title:Mathematical biosciences

    pub_type: 杂志文章

    doi:10.1016/0025-5564(92)90024-q

    authors: Kallianpur G

    更新日期:1992-12-01 00:00:00

  • Time delay in physiological systems: analyzing and modeling its impact.

    abstract::This article examines the functional and clinical impact of time delays that arise in human physiological systems, especially control systems. An overview of the mathematical and physiological contexts for considering time delays will be illustrated, from the system level to cell level, by examining models that incorp...

    journal_title:Mathematical biosciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.mbs.2011.08.006

    authors: Batzel JJ,Kappel F

    更新日期:2011-12-01 00:00:00

  • Fishery policy when considering the future opportunity of harvesting.

    abstract::Free access to a common pool of resource in a country may lead to over-exploitation and sacrifice future opportunities of harvesting. As such, the protection of a common fishery resource is worth investigating. In this paper we develop a two-period model and a multi-period model to analyze the optimal inter-temporal u...

    journal_title:Mathematical biosciences

    pub_type: 杂志文章

    doi:10.1016/j.mbs.2006.06.007

    authors: Chen CC,Hsui CY

    更新日期:2007-05-01 00:00:00

  • An age-structured model for pertussis transmission.

    abstract::The vaccination program for pertussis (whooping cough) in the United States consists of giving multiple doses of pertussis vaccine to young children. A demographic model with a steady-state age distribution is used as a basis for building an epidemiologic model for the transmission of pertussis. This age-structured mo...

    journal_title:Mathematical biosciences

    pub_type: 历史文章,杂志文章

    doi:10.1016/s0025-5564(97)00014-x

    authors: Hethcote HW

    更新日期:1997-10-15 00:00:00

  • Learning of oscillatory correlated patterns in a cortical network by a STDP-based learning rule.

    abstract::In this paper, we propose an iterative learning rule that allows the imprinting of correlated oscillatory patterns in a model of the hippocampus able to work as an associative memory for oscillatory spatio-temporal patterns. We analyze the dynamics in the Fourier domain, showing how the network selectively amplify or ...

    journal_title:Mathematical biosciences

    pub_type: 杂志文章

    doi:10.1016/j.mbs.2006.10.001

    authors: Marinaro M,Scarpetta S,Yoshioka M

    更新日期:2007-06-01 00:00:00

  • Generalised probability mass function for the final epidemic size of an SIR model on a line of triangles network.

    abstract::We explore the feasibility of deriving generalised expressions for the probability mass function (PMF) of the final epidemic size of a Susceptible - Infected - Recovered (SIR) model on a finite network of an arbitrary number of nodes. Expressions for the probability that the infection progresses along a given pathway ...

    journal_title:Mathematical biosciences

    pub_type: 杂志文章

    doi:10.1016/j.mbs.2019.02.003

    authors: McCulloch K,Roberts MG,Laing CR

    更新日期:2019-05-01 00:00:00

  • Similarity transformation approach to identifiability analysis of nonlinear compartmental models.

    abstract::Through use of the local state isomorphism theorem instead of the algebraic equivalence theorem of linear systems theory, the similarity transformation approach is extended to nonlinear models, resulting in finitely verifiable sufficient and necessary conditions for global and local identifiability. The approach requi...

    journal_title:Mathematical biosciences

    pub_type: 杂志文章

    doi:10.1016/0025-5564(89)90024-2

    authors: Vajda S,Godfrey KR,Rabitz H

    更新日期:1989-04-01 00:00:00

  • Stability and backward bifurcation in a malaria transmission model with applications to the control of malaria in China.

    abstract::In this paper, we consider a deterministic malaria transmission model with standard incidence rate and treatment. Human population is divided into susceptible, infectious and recovered subclasses, and mosquito population is split into susceptible and infectious classes. It is assumed that, among individuals with malar...

    journal_title:Mathematical biosciences

    pub_type: 杂志文章

    doi:10.1016/j.mbs.2015.05.005

    authors: Feng X,Ruan S,Teng Z,Wang K

    更新日期:2015-08-01 00:00:00

  • Optimal control of receptor reinsertion in the low density lipoprotein endocytic cycle.

    abstract::On the basis of this study, it is concluded that within physiological limits the minimum value for the mean capture time of LDL receptors by coated pits must be induced fundamentally by an optimal characterization of their insertion rate function. The corresponding steady-state surface aggregation patterns for the unb...

    journal_title:Mathematical biosciences

    pub_type: 杂志文章

    doi:10.1016/s0025-5564(99)00043-7

    authors: Echavarría-Heras H

    更新日期:1999-11-01 00:00:00

  • Division of labor in bacterial populations.

    abstract::Cooperating behaviors abound across all domains of life, but are vulnerable to invasion by cheaters. An important evolutionary question is to determine mechanisms that stabilize and maintain cooperation levels and prevent population collapse. Policing is one strategy populations may employ to achieve this goal, and it...

    journal_title:Mathematical biosciences

    pub_type: 杂志文章

    doi:10.1016/j.mbs.2019.108257

    authors: Lynn BK,De Leenheer P

    更新日期:2019-10-01 00:00:00

  • Random and non-random mating populations: Evolutionary dynamics in meiotic drive.

    abstract::Game theoretic tools are utilized to analyze a one-locus continuous selection model of sex-specific meiotic drive by considering nonequivalence of the viabilities of reciprocal heterozygotes that might be noticed at an imprinted locus. The model draws attention to the role of viability selections of different types to...

    journal_title:Mathematical biosciences

    pub_type: 杂志文章

    doi:10.1016/j.mbs.2015.10.013

    authors: Sarkar B

    更新日期:2016-01-01 00:00:00

  • Spatial synchrony in host-parasitoid models using aggregation of variables.

    abstract::We consider a host-parasitoid system with individuals moving on a square grid of patches. We study the effects of increasing movement frequency of hosts and parasitoids on the spatial dynamics of the system. We show that there exists a threshold value of movement frequency above which spatial synchrony occurs and the ...

    journal_title:Mathematical biosciences

    pub_type: 杂志文章

    doi:10.1016/j.mbs.2006.03.019

    authors: Nguyen-Huu T,Lett C,Auger P,Poggiale JC

    更新日期:2006-10-01 00:00:00

  • Visibility in a pure model of golden spiral phyllotaxis.

    abstract::This paper considers the geometry of plants with golden spiral phyllotaxis, i.e. growing leaf by leaf on a spiral with golden divergence angle, via the simplest mathematical model, a cylinder with regular arrangement of points on its surface. As is well-known, Fibonacci numbers appear by means of the order of parastic...

    journal_title:Mathematical biosciences

    pub_type: 杂志文章

    doi:10.1016/j.mbs.2018.05.003

    authors: Herrmann B

    更新日期:2018-07-01 00:00:00

  • A model of HIV/AIDS with staged progression and amelioration.

    abstract::An epidemic model with multiple stages of infection is studied. The model allows for infected individuals to move from advanced stages of infection back to less advanced stages of infection. A threshold parameter which determines the local stability of the disease free equilibrium is found and interpreted. Under condi...

    journal_title:Mathematical biosciences

    pub_type: 杂志文章

    doi:10.1016/s0025-5564(02)00149-9

    authors: McCluskey CC

    更新日期:2003-01-01 00:00:00

  • A new approach of fitting biomass dynamics models to data.

    abstract::A non-traditional approach of fitting dynamic resource biomass models to data is developed in this paper. A variational adjoint technique is used for dynamic parameter estimation. In the variational formulation, a cost function measuring the distance between the model solution and the observations is minimized. The da...

    journal_title:Mathematical biosciences

    pub_type: 杂志文章

    doi:10.1016/s0025-5564(02)00178-5

    authors: Ussif AA,Sandal LK,Steinshamn SI

    更新日期:2003-03-01 00:00:00

  • A comparison of different bivariate correlated frailty models and estimation strategies.

    abstract::Frailty models are becoming increasingly popular in multivariate survival analysis. Shared frailty models in particular are often used despite their limitations. To overcome their disadvantages numerous correlated frailty models were established during the last decade. In the present study, we examine bivariate correl...

    journal_title:Mathematical biosciences

    pub_type: 杂志文章

    doi:10.1016/j.mbs.2004.11.010

    authors: Wienke A,Arbeev KG,Locatelli I,Yashin AI

    更新日期:2005-11-01 00:00:00

  • Recent advances in mathematical modeling and statistical analysis of exocytosis in endocrine cells.

    abstract::Most endocrine cells secrete hormones as a result of Ca2+-regulated exocytosis, i.e., fusion of the membranes of hormone-containing secretory granules with the cell membrane, which allows the hormone molecules to escape to the extracellular space. As in neurons, electrical activity and cell depolarization open voltage...

    journal_title:Mathematical biosciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.mbs.2016.11.010

    authors: Pedersen MG,Tagliavini A,Cortese G,Riz M,Montefusco F

    更新日期:2017-01-01 00:00:00

  • Effective rate models for the analysis of transport-dependent biosensor data.

    abstract::Optical biosensors, including the BIACORE, provide an increasingly popular method for determining reaction rates of biomolecules. In a flow chamber, with one reactant immobilized on a chip on the sensor surface, a solution containing the other reactant (the analyte) flows through the chamber. The time course of bindin...

    journal_title:Mathematical biosciences

    pub_type: 杂志文章

    doi:10.1016/s0025-5564(99)00023-1

    authors: Mason T,Pineda AR,Wofsy C,Goldstein B

    更新日期:1999-07-01 00:00:00

  • Stochastic disease dynamics of a hospital infection model.

    abstract::A stochastic model for hospital infection incorporating both direct transmission and indirect transmission via free-living bacteria in the environment is investigated. We examine the long term behavior of the model by calculating a stationary distribution and normal approximation of the distribution. The quasi-station...

    journal_title:Mathematical biosciences

    pub_type: 杂志文章

    doi:10.1016/j.mbs.2012.10.002

    authors: Wang X,Xiao Y,Wang J,Lu X

    更新日期:2013-01-01 00:00:00

  • Coherent potential approximation approach to electronic structure of DNA.

    abstract::The electronic structure of DNA is theoretically investigated by use of the coherent potential approximation. Even when the sequence of the four kinds of bases is nonperiodic, guanine block forms the persistent highest valence band edge, and adenine block forms the persistent lowest conduction band edge state. Accordi...

    journal_title:Mathematical biosciences

    pub_type: 杂志文章

    doi:10.1016/0025-5564(94)00118-5

    authors: Takeda K

    更新日期:1995-12-01 00:00:00

  • Qualitative analysis of models with different treatment protocols to prevent antibiotic resistance.

    abstract::This paper is concerned with the qualitative analysis of two models [S. Bonhoeffer, M. Lipsitch, B.R. Levin, Evaluating treatment protocols to prevent antibiotic resistance, Proc. Natl. Acad. Sci. USA 94 (1997) 12106] for different treatment protocols to prevent antibiotic resistance. Detailed qualitative analysis abo...

    journal_title:Mathematical biosciences

    pub_type: 杂志文章

    doi:10.1016/j.mbs.2010.06.002

    authors: Sun HR,Lu X,Ruan S

    更新日期:2010-09-01 00:00:00

  • Assessing three fish species ecological status in Colorado River, Grand Canyon based on physical habitat and population models.

    abstract::Colorado River is a unique ecosystem and provides important ecological services such as habitat for fish species as well as water power energy supplies. River management for this ecosystem requires assessment and decision support tools for fish which involves protecting, restoring as well as forecasting of future cond...

    journal_title:Mathematical biosciences

    pub_type: 杂志文章

    doi:10.1016/j.mbs.2018.02.006

    authors: Yao W,Chen Y

    更新日期:2018-04-01 00:00:00

  • Persistence of an infectious disease in a subdivided population.

    abstract::The transmission dynamics of a communicable disease in a subdivided population where the spread among groups follows the proportionate mixing model while the within-group transmission can correspond to preferred mixing, proportionate mixing among subgroups, or mixing between social and nonsocial subgroups, is analyzed...

    journal_title:Mathematical biosciences

    pub_type: 杂志文章

    doi:10.1016/0025-5564(89)90061-8

    authors: Andreasen V,Christiansen FB

    更新日期:1989-10-01 00:00:00

  • Maximum sustainable yield with continuous age structure and density-dependent recruitment.

    abstract::The problem addressed is that of finding the harvesting policy that will maximize the yield and maintain a given population in a steady state. It is assumed that the equations describing the evolution of the population and the yield are linear but that the equation describing reproduction is nonlinear (density depende...

    journal_title:Mathematical biosciences

    pub_type: 杂志文章

    doi:10.1016/0025-5564(94)90039-6

    authors: Dacorogna B,Weissbaum F,Arditi R

    更新日期:1994-03-01 00:00:00

  • An algebraic analysis of the two state Markov model on tripod trees.

    abstract::Methods of phylogenetic inference use more and more complex models to generate trees from data. However, even simple models and their implications are not fully understood. Here, we investigate the two-state Markov model on a tripod tree, inferring conditions under which a given set of observations gives rise to such ...

    journal_title:Mathematical biosciences

    pub_type: 杂志文章

    doi:10.1016/j.mbs.2012.03.001

    authors: Klaere S,Liebscher V

    更新日期:2012-05-01 00:00:00