Abstract:
:Apathy, usually defined as loss of motivation, is common in both neurodegenerative conditions such as Alzheimer's disease, and acute neurological disorders such as stroke. Neuroradiological studies on the imaging correlates of apathy have used a variety of methods such as structural and functional magnetic resonance imaging, diffusion tensor imaging, and single photon and positron emission tomography to assess brain metabolic activity and specific synaptic receptors. Dysfunction of the anterior cingulate cortex (ACC) is the strongest anatomical correlate of apathy in Alzheimer's disease, whereas lesions of the basal ganglia are the most common correlates of apathy in cerebrovascular disorders. These findings should be considered in the context of important conceptual and empirical limitations. There are diverging definitions of apathy, and this behavioural disorder has not yet been validated in most neurological conditions. Moreover, apathy may be related not only to specific brain dysfunction, but to relevant contextual confounders which deserve further study.
journal_name
Neuropsychologiajournal_title
Neuropsychologiaauthors
Starkstein SE,Brockman Sdoi
10.1016/j.neuropsychologia.2018.01.042subject
Has Abstractpub_date
2018-09-01 00:00:00pages
48-53issue
Pt Beissn
0028-3932issn
1873-3514pii
S0028-3932(18)30048-4journal_volume
118pub_type
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