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Evaluation of the effects of intrathecal bupivacaine-dexmedetomidine for lumbar spine fusion: a double blinded randomized controlled study.

Abstract：

OBJECTIVE:To evaluate the efficacy of intrathecal dexmedetomidine at improving the quality of the operative field, and prolonging the duration of sensory block, motor block, and postoperative analgesia during spinal surgery PATIENTS AND METHODS:This prospective, double-blinded, randomized controlled study included 52 patients undergoing an instrumented one-level posterolateral lumbar spine fusion for lumbar spondylolisthesis under spinal anesthesia. The patients were randomized into two groups: group D (n = 26) received 15 mg of hyperbaric bupivacaine with 5 μg of dexmedetomidine, while group P (n = 26) received 15 mg of hyperbaric bupivacaine only. The operative field quality score, blood loss volume, and the surgeon's satisfaction with the procedure were recorded. The onset time of the sensory block, time to reach peak sensory level, sensory and motor regression times, time to the first requirement of analgesia, sedation level, hemodynamics, and all postoperative complications were also recorded. RESULTS:The operative field quality and the surgeon's satisfaction scores (rated excellent) were significantly better in group D than in group P (p < 0.0001 and p = 0.003, respectively). Patients in group D had significantly longer sensory and motor regression times than patients in group P (p < 0.0001). The time to the first requirement of analgesia and the total dose of ketorolac was significantly longer and smaller, respectively, in group D than in group P (p < 0.0001). CONCLUSIONS:Intrathecal bupivacaine-dexmedetomidine improved the quality of the operative field, prolonged the duration of the sensory and motor block, prolonged postoperative analgesia, and produced minimal side effects.

journal_name

Eur Rev Med Pharmacol Sci

journal_title

European review for medical and pharmacological sciences

authors

Salem RA,Darweesh EI,Wanis MA,Mohamed AA

subject

Has Abstract

pub_date

2015-12-01 00:00:00

pages

4542-8

issue

eissn

1128-3602

issn

2284-0729

journal_volume

pub_type

杂志文章,随机对照试验

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Evaluation of the effects of intrathecal bupivacaine-dexmedetomidine for lumbar spine fusion: a double blinded randomized controlled study.