[Small Cell Lung Cancer].

Abstract:

:Small cell lung cancer accounts for roughly 14% of all lung cancers and is characterized by rapid progression, early distant metastasis and poor prognosis. Only a minority of patients presents with early stage disease upon initial diagnosis where surgical resection may be discussed. In addition, various treatment modalities demonstrate effectiveness including chemotherapy and radiotherapy. However, although most patients respond to platinum doublet chemotherapy, virtually all patients with metastatic disease eventually develop tumor progression for which there are limited treatment options. Novel therapeutic approaches such as immune checkpoint inhibitors or the antibody drug conjugate rovalpituzumab tesirine show promising results in early clinical trials and might broaden our treatment options in the future. :Das kleinzellige Lungenkarzinom stellt eine besonders aggressive Tumorentität dar und ist durch schnellen Progress, sehr frühe Metastasierung und schlechte Prognose charakterisiert. Nur wenige Patienten werden in einem frühen Erkrankungsstadium diagnostiziert, bei dem in ausgewählten Fällen eine chirurgische Resektion diskutiert werden kann. Chemotherapie und Strahlentherapie sind initial häufig effektiv. Allerdings erleiden die meisten Patienten im metastasierten Stadium nach zunächst gutem Ansprechen auf eine platinhaltige Chemotherapie einen Progress mit dann nur limitierten Therapieoptionen.

journal_name

Zentralbl Chir

authors

Reinmuth N,Hoffmann H

doi

10.1055/s-0043-110185

subject

Has Abstract

pub_date

2018-02-01 00:00:00

pages

103-116

issue

1

eissn

0044-409X

issn

1438-9592

journal_volume

143

pub_type

杂志文章,评审
  • [Breast carcinoma in pregnancy. Clinical, histological and immunohistochemical findings].

    abstract::The hormonally induced changes in the breast during pregnancy make the diagnosis of breast cancer difficult. Furthermore, examinations during pregnancy tend to concentrate only on the pregnancy itself. In this report the clinical, pathological and immunohistochemical results from 7 patients with breast cancer during p...

    journal_title:Zentralblatt fur Chirurgie

    pub_type: 杂志文章

    doi:

    authors: Meden H,Marx D,Rath W,Tsikuras P,Kuhn W,Schauer A

    更新日期:1992-01-01 00:00:00

  • [Time of disablement after partial gastrectomy for peptic ulcer (author's transl)].

    abstract::From 1966 to 1975 1169 patients underwent a partial gastrectomy (Billroth-II). 944 patients (80%) were followed up by their surgeons in a so call "gastric after-care". On the average these patients were pstoperatively out of work for 58 days. This time depends on postoperative complications, disturbed gastric function...

    journal_title:Zentralblatt fur Chirurgie

    pub_type: 杂志文章

    doi:

    authors: Böttner R,Michelsen M,Doese FW,Steffen G

    更新日期:1977-01-01 00:00:00

  • [Liver metastases from neuroendocrine tumours of the gastroenteropancreatic system--therapeutic strategies].

    abstract::Neuroendocrine tumours (NET) differ appreciably with regard to their biological behaviour from tumours of epithelial origin. In general this leads to a better 5-year survival rate. Liver metastases per se and also in cases of NET result in a significantly poorer survival in comparison to tumours without metastases. In...

    journal_title:Zentralblatt fur Chirurgie

    pub_type: 杂志文章,评审

    doi:10.1055/s-0029-1224607

    authors: Auernhammer CJ,Jauch KW,Hoffmann JN

    更新日期:2009-09-01 00:00:00

  • [Hiatal hernia; 359 cases. Late results].

    abstract::From 1948 to 1977 359 patients suffering from oesophageal reflux disorders or the hiatus-hernia-complex underwent surgery at the I. Surgical clinic of the Medical Faculty Palacky-Univ. in Olomouc. In the group of 50 patients with simple paraaesophageal hernias the operative mortality came up to 4.0%. The mortality rat...

    journal_title:Zentralblatt fur Chirurgie

    pub_type: 杂志文章

    doi:

    authors: Serý Z,Duda M,Rocek V

    更新日期:1981-01-01 00:00:00

  • [Postoperative follow-up and body weight after gastric banding].

    abstract:BACKGROUND:Since 1983 gastric banding has become a proven operative method, which reduces effectively excess weight in morbid obesity. Gastric banding has been popularized as a minimally invasive, completely reversible surgical treatment for morbid obesity. We report here our 4 year experiences of gastric banding with ...

    journal_title:Zentralblatt fur Chirurgie

    pub_type: 杂志文章

    doi:10.1055/s-2000-10650

    authors: Stroh C,Schramm H

    更新日期:2000-01-01 00:00:00

  • [Complete Mesocolic Excision for Right-Sided Colon Cancer - The Role of Central Lymph Nodes].

    abstract:BACKGROUND:Complete mesocolic excision (CME) and central vascular ligation (CVL) for right-sided colon cancer may be superior to standard hemicolectomy in terms of oncological results. This hypothesis is currently being investigated in a large multicentre trial conducted by the authors of this paper (Resektatstudie). B...

    journal_title:Zentralblatt fur Chirurgie

    pub_type: 杂志文章,多中心研究

    doi:10.1055/s-0034-1383133

    authors: Benz SR,Tannapfel A,Tam Y,Stricker I

    更新日期:2015-08-01 00:00:00

  • [Douglas' abscess with ureteric obstruction (author's transl)].

    abstract::In a 19 year old man with a single kidney the development of a large Douglas' abscess was followed by anuria; The various causes are discussed. It is resonable to assume, that the obstruction resulted from longitudinal tension of the ureter over the iliace vessels (iliac sign). ...

    journal_title:Zentralblatt fur Chirurgie

    pub_type: 杂志文章

    doi:

    authors: Heidler H,Dinstl K,Schiessl R

    更新日期:1976-01-01 00:00:00

  • [Disordered postoperative course. A retrospective analysis].

    abstract::A brief definition of the term of "relaparotomy" is followed by reference to some causes of erroneous or delayed decisionmaking on re-operation. The background of postoperative disorders is, basically, one and the same throughout acute surgery: haemorrhage, peritonitis, ileus. Relaparotomy was necessary in 0.6 per cen...

    journal_title:Zentralblatt fur Chirurgie

    pub_type: 杂志文章

    doi:

    authors: Günther K,Taubert E,Mehwald J

    更新日期:1988-01-01 00:00:00

  • [Retrograde intramedullary nailing in proximal fracture of the humerus in the elderly patient. Results of a minimally invasive management concept].

    abstract::Retrograde intramedullary fixation of proximal humerus fractures with flexible wires was evaluated in a prospectively documented study. Seventy-four fractures in 73 patients with unstable proximal humerus shaft or neck fractures were fixed with 3-11 flexible intramedullary wires. The age of the patients averaged 72 ye...

    journal_title:Zentralblatt fur Chirurgie

    pub_type: 杂志文章

    doi:

    authors: Hoffmann R,Khodadadyan C,Raschke M,Melcher I,Maitino PD,Haas NP

    更新日期:1998-01-01 00:00:00

  • [Indications and results of sacral nerve stimulation in faecal incontinence].

    abstract:BACKGROUND:Sacral nerve stimulation (SNS) is an effective and less invasive treatment of faecal incontinence (FI). Patient selection has evolved from strict criteria to a more liberal approach, since temporary testing reliably predicts the efficacy of permanent stimulation in FI of various aetiologies. PATIENTS AND ME...

    journal_title:Zentralblatt fur Chirurgie

    pub_type: 杂志文章

    doi:10.1055/s-2008-1004737

    authors: Stelzner S,Köhler K,Hellmich G,Witzigmann H

    更新日期:2008-04-01 00:00:00

  • [Kidney transplantation in Germany - 2002].

    abstract::In Germany the number of kidney transplantations has increased rather slowly during recent years. While living donations increased, the number of postmortal donations decreased during the same time. In order to lower the number of patients on the waiting lists in Germany, the rate of postmortal or living donations as ...

    journal_title:Zentralblatt fur Chirurgie

    pub_type: 杂志文章

    doi:10.1055/s-2003-44335

    authors: Lutz J,Stangl M,Heemann U

    更新日期:2003-10-01 00:00:00

  • [Wound dressings in chronic wounds].

    abstract::Hydroactive wound dressings retain exsudate in the wound region or incorporate wound exsudate by gel formation. They create the local environment for moist wound healing which is experimentally and clinically characterized by accelerated reepithelialization, inflammatory reaction and angiogenesis as well as reduced wo...

    journal_title:Zentralblatt fur Chirurgie

    pub_type: 杂志文章,评审

    doi:

    authors: Mohr VD,Spelter H,Schmidt J,Zirngibl H

    更新日期:1999-01-01 00:00:00

  • [Surgical therapy of complicated sigmoid diverticulitis: single stage or multi-stage operation?].

    abstract::Surgical tactics for the teatment of complicated diverticulitis are in constant evolution and remain a subject of controversy. Amongst 53 patients operated on for complicated sigmoid diverticulits over a 10 year period in our hospital, 29 underwent a Hartmann's procedure (3 Hinchey's stage II, 19 stage III and 7 stage...

    journal_title:Zentralblatt fur Chirurgie

    pub_type: 杂志文章,评审

    doi:

    authors: Gertsch P,al-Muaid J,Pelloni A,Bogen M

    更新日期:1998-01-01 00:00:00

  • [Possibilities for using emergency abdominal ultrasound study and its significance in acute diseases of the abdominal cavity].

    abstract::Studies were conducted by the authors' of this paper into the diagnostic value of ultrasonic examination to clear up suspicion of acute abdominal problems, with 381 examinations being actually evaluated. Definitely valid diagnosis was obtained from the method in 37.7 per cent of these cases. The tentative diagnosis wa...

    journal_title:Zentralblatt fur Chirurgie

    pub_type: 杂志文章

    doi:

    authors: Baricza S,Vadnai M,Varga Z,Herczeg B

    更新日期:1988-01-01 00:00:00

  • ["Acute cholecystitis"--laparoscopic cholecystectomy is often possible. Results of a multicenter study by the East German Study Group for Performance Assessment and Quality Assurance in Surgery].

    abstract::With the introduction of laparoscopic cholecystectomy (LCE) the method became very fast successful in clinical practice. To describe the actual situation we initiated in 1994/95 a clinical multicenter study with the name CESAQ. 29 hospitals participated in the study. 4,675 cholecystectomies were performed, a total num...

    journal_title:Zentralblatt fur Chirurgie

    pub_type: 杂志文章,多中心研究

    doi:

    authors: Dietzel M,Lippert H,Gastinger I,Schramm H

    更新日期:2000-01-01 00:00:00

  • [Fibroplastic peritonitis (author's transl)].

    abstract::2 cases of peritonitis fibroplastica with obscure genesis and atypical complaints were operated on. Pseudomembranes were carefully cleared away from the intestine. The first patient has been cured after two years, the other died of another disease. ...

    journal_title:Zentralblatt fur Chirurgie

    pub_type: 杂志文章

    doi:

    authors: Emmanouilidis T,Wellmer HK

    更新日期:1978-01-01 00:00:00

  • [Benign prostatic hyperplasia].

    abstract::The aetiological background of benign prostatic hyperplasia (BPH) is still obscure, though new information is steadily gained. In the context of pathomorphogenesis, major importance seems to be attributable to fibromuscular (stromal) tissue, since evidence has been produced to significant decline in glanduloparenchyma...

    journal_title:Zentralblatt fur Chirurgie

    pub_type: 杂志文章

    doi:

    authors: Schönberger B

    更新日期:1986-01-01 00:00:00

  • [Anti-infectious regime and bacteriological status].

    abstract::The functioning of our anti-infectious regimen now working over a period of 7 years with 4 checks per year has been controlled. The wound infection rate came up to a percentage of 1.55. Blunders concerning chemical disinfection especially could be detected in spite of check-ups made every 3 months. ...

    journal_title:Zentralblatt fur Chirurgie

    pub_type: 杂志文章

    doi:

    authors: Siggelkow G

    更新日期:1982-01-01 00:00:00

  • [Systematic Readability Analysis of Medical Texts on Websites of German University Clinics for General and Abdominal Surgery].

    abstract::Background: Besides the function as one of the main contact points, websites of hospitals serve as medical information portals. As medical information texts should be understood by any patients independent of the literacy skills and educational level, online texts should have an appropriate structure to ease understan...

    journal_title:Zentralblatt fur Chirurgie

    pub_type: 杂志文章

    doi:10.1055/s-0034-1383381

    authors: Esfahani BJ,Faron A,Roth KS,Grimminger PP,Luers JC

    更新日期:2016-12-01 00:00:00

  • [Extended resections in bronchial cancer: complications and late results].

    abstract::From 1982 through April 1992, 192 patients underwent extended resection for non-small cell carcinoma of the lung (NSCLC) invading the chest wall (n = 52) or the mediastinum (n = 140). Complete resection of the tumor was possible in 81 (58%) patients with invasion of mediastinum and in 34 (65%) patients with invasion o...

    journal_title:Zentralblatt fur Chirurgie

    pub_type: 杂志文章

    doi:

    authors: Dienemann H,Hoffmann H,Mewes A,Müller C,Schildberg FW

    更新日期:1993-01-01 00:00:00

  • [Selection of the treatment method in rectal cancer].

    abstract::From 1956 to 1982, 4126 patients suffering from rectal cancer underwent surgery, 3229 of them had radical operations. The total postoperative mortality rate came up to 7.1% (n = 295) in the radical operated group it was 6.6% (n = 214). Between 1956 to 1982 continence preserving surgical procedures were constantly on t...

    journal_title:Zentralblatt fur Chirurgie

    pub_type: 杂志文章

    doi:

    authors: Fedorov VD

    更新日期:1985-01-01 00:00:00

  • [Surgical palliation for pancreatic cancer. The 25-year experience of a single reference centre].

    abstract:BACKGROUND:In spite of dynamic development of modern diagnostic and therapeutic methods, the long-term results of surgical therapy in pancreatic cancer are still unsatisfying. The aim of this study was to analyse long-term results of surgical palliation for pancreatic cancer in a pancreatic surgery centre. METHODS:We ...

    journal_title:Zentralblatt fur Chirurgie

    pub_type: 杂志文章

    doi:10.1055/s-2002-35760

    authors: Popiela T,Kedra B,Sierzega M,Kubisz A

    更新日期:2002-11-01 00:00:00

  • [Asbestos-induced malignant mesothelioma of the tunica vaginalis testis].

    abstract::Since 1977 the diffuse malignant mesothelioma of the pleura and peritoneum caused by asbestos represents one of the most often compensated occupational cancers in Germany. Because of the probability of an asbestos-related etiology, it is considered as a "signal tumour", mainly indicating exposure to asbestos dust at t...

    journal_title:Zentralblatt fur Chirurgie

    pub_type: 杂志文章

    doi:10.1055/s-2001-12499

    authors: Schneider J,Woitowitz HJ

    更新日期:2001-03-01 00:00:00

  • [Injuries and being injured. Hidden wounds after accident injuries].

    abstract::Motor vehicle accidents may cause apart from physical also psychological aftermath. Despite of posttraumatic psychologic symptoms may remit after 2-3 months, 10-20% of the injured persons will develop sustainable psychopathological symptoms. This report aims at an overview on possible psychopathological disturbances a...

    journal_title:Zentralblatt fur Chirurgie

    pub_type: 杂志文章,评审

    doi:10.1055/s-2000-10676

    authors: Meyer C,Markgraf E

    更新日期:2000-01-01 00:00:00

  • [Results of the surgical management of frontobasal injuries].

    abstract::The author reports about 183 patients with frontobasal injuries. 50 per cent of them were operated immediately because open injuries or intracranial complications. The other half was operated in an interval of 5 to 10 days after injury. The localisation of the frontobasal lesion, clinical results according to the Glas...

    journal_title:Zentralblatt fur Chirurgie

    pub_type: 杂志文章

    doi:

    authors: Klötzer R,Meier U,Knopf W

    更新日期:1991-01-01 00:00:00

  • [Peridural anesthesia in postoperative pain therapy].

    abstract::This review gives a summary of historical developments of the technique of epidural anaesthesia as well as a synopsis of current knowledges in this method of regional anaesthesia. Besides of anatomical basics, the technique of epidural anaesthesia and its use in postoperative pain relief including indications, contrai...

    journal_title:Zentralblatt fur Chirurgie

    pub_type: 杂志文章,评审

    doi:

    authors: Standl T

    更新日期:1995-01-01 00:00:00

  • [Minimal invasive cannulated screw osteosynthesis of Bennett's fractures].

    abstract:PURPOSE OF THE STUDY:The current study presents a new technique and results of minimal invasive screw osteosynthesis in the treatment of Bennett's fractures and discusses its advantages and disadvantages. OPERATIVE TECHNIQUE:The Bennett's fragment has to be of sufficient size (at least one quarter of the articular sur...

    journal_title:Zentralblatt fur Chirurgie

    pub_type: 杂志文章

    doi:10.1055/s-2003-40628

    authors: Meyer C,Hartmann B,Böhringer G,Horas U,Schnettler R

    更新日期:2003-06-01 00:00:00

  • [Hierarchy and authority].

    abstract::Although the term hierarchy isn't in keeping with the times for secular spheres, the identical term ranking omnipresent and indispensable in a political way. Without ranking there ist no final but only a general responsibility. Ranking is based on authority--to be distinguished between professional competence an offic...

    journal_title:Zentralblatt fur Chirurgie

    pub_type: 杂志文章

    doi:

    authors: Horntrich J

    更新日期:1999-01-01 00:00:00

  • [Hemostasis in the liver, lungs, and spleen using an infra-red contact coagulator].

    abstract::Experiments in rats and dogs showed that bleeding of parenchymal organs can be stopped quickly and reliable by using a recently developed infrared contact coagulator (ICC). Haemostasis of liver parenchyma was established in a shorter time than by usual diathermo-coagulation. Due to this reduced time of coagulation sma...

    journal_title:Zentralblatt fur Chirurgie

    pub_type: 杂志文章

    doi:

    authors: Welter H,Seifert J,Nath G,Kreitmair A,Eberhardt H,Gokel JM

    更新日期:1980-01-01 00:00:00

  • [Mortality and morbidity following surgical therapy of perforated gastroduodenal ulcers].

    abstract::A retrospective study was conducted into 136 patients who had received surgical treatment for perforated gastroduodenal ulcers, with the view to establishing postoperative lethality and morbidity (comparing simple suturing with definitive ulcer surgery). Factors of relevance to prognosis were taken into consideration,...

    journal_title:Zentralblatt fur Chirurgie

    pub_type: 杂志文章

    doi:

    authors: Bäumer F

    更新日期:1987-01-01 00:00:00