Determining Genetic Causal Variants Through Multivariate Regression Using Mixture Model Penalty.

abstract：:Germline variants of PIP4K2A impact susceptibility of acute lymphoblastic leukemia (ALL) through inducing its overexpression. Although limited reports suggested the oncogenic role of PIP4K2A in cancers, regulatory network and prognostic effect of this gene remains poorly understood in tumorigenesis and leukemogenesis....

journal_title：Frontiers in genetics

authors： Zhang S,Li Z,Yan X,Bao L,Deng Y,Zeng F,Wang P,Zhu J,Yin D,Liao F,Zhou X,Zhang D,Xia X,Wang H,Yang X,Zhang W,Gao H,Zhang W,Yang L,Hou Q,Xu H,Zhang Y,Shu Y,Wang Y

更新日期：2019-01-15 00:00:00

abstract：:Usher type 1 syndrome is a rare autosomal recessive disorder involving congenital severe-to-profound hearing loss, development of vision impairment in the first decade, and severe balance difficulties. The PCDH15 gene, one of the five genes implicated in this disease, is involved in 8-20% of cases. In this study, we a...

journal_title：Frontiers in genetics

authors： Vaché C,Puechberty J,Faugère V,Darmaisin F,Liquori A,Baux D,Blanchet C,Garcia-Garcia G,Meunier I,Pellestor F,Koenig M,Roux AF

更新日期：2020-07-02 00:00:00

abstract：:Our understanding of the mechanisms governing the response to DNA damage in higher eucaryotes crucially depends on our ability to dissect the temporal and spatial organization of the cellular machinery responsible for maintaining genomic integrity. To achieve this goal, we need experimental tools to inflict DNA lesion...

journal_title：Frontiers in genetics

authors： Ferrando-May E,Tomas M,Blumhardt P,Stöckl M,Fuchs M,Leitenstorfer A

更新日期：2013-07-16 00:00:00

abstract：:Imprinted loci play a critical role in fetal development. Their expression is often regulated by CCCTC-binding factor (CTCF) protein binding at imprinting control regions (ICRs). Prenatal alcohol exposure has been shown to reduce global DNA methylation in the developing mouse fetus. This study explored the effect of p...

journal_title：Frontiers in genetics

authors： Knezovich JG,Ramsay M

更新日期：2012-02-22 00:00:00

abstract：:Bovine viral diarrhea virus (BVDV) is an RNA virus that is often associated with respiratory disease in cattle. MicroRNAs have been proposed as indicators of exposure to respiratory pathogens. The objective of this study was to identify microRNAs in cattle that had been challenged with a non-cytopathic field strain of...

journal_title：Frontiers in genetics

authors： Taxis TM,Bauermann FV,Ridpath JF,Casas E

更新日期：2017-06-28 00:00:00

abstract：:Advanced castrate-resistant prostate cancer (CRPC) is a poorly prognostic disease currently lacking effective cure. Understanding the molecular mechanism that underlies the initiation and progression of CRPC will provide new strategies for treating this deadly disease. One candidate target is the fibroblast growth fac...

journal_title：Frontiers in genetics

authors： Wang C,Liu Z,Ke Y,Wang F

更新日期：2019-01-30 00:00:00

abstract：:Circadian rhythms produce a biological measure of the time of day. In plants, circadian regulation forms an essential adaptation to the fluctuating environment. Most of our knowledge of the molecular aspects of circadian regulation in plants is derived from laboratory experiments that are performed under controlled co...

journal_title：Frontiers in genetics

authors： Panter PE,Muranaka T,Cuitun-Coronado D,Graham CA,Yochikawa A,Kudoh H,Dodd AN

更新日期：2019-11-29 00:00:00

abstract：:The first breeding program in the world for durum wheat was conceived in Italy in the early 1900s. Over the decades, pressure exerted by natural and artificial selection could have progressively reduced the genetic diversity of the durum wheat germplasm. In the present study, a large panel of Italian durum wheat acces...

journal_title：Frontiers in genetics

authors： Taranto F,D'Agostino N,Rodriguez M,Pavan S,Minervini AP,Pecchioni N,Papa R,De Vita P

更新日期：2020-04-21 00:00:00

abstract：:Network propagation is a central tool in biological research. While a number of variants and normalizations have been proposed for this method, each has its own shortcomings and no large scale assessment of those variants is available. Here we propose a novel normalization method for network propagation that is based ...

journal_title：Frontiers in genetics

authors： Biran H,Kupiec M,Sharan R

更新日期：2019-01-22 00:00:00

abstract：:Cell secretion is an important physiological process that ensures smooth metabolic activities and tissue repair as well as growth and immunological functions in the body. Apocrine secretion occurs when the secretory process is accomplished with a partial loss of cell cytoplasm. The secretory materials are contained wi...

journal_title：Frontiers in genetics

authors： Ishikawa T,Toyoda Y,Yoshiura K,Niikawa N

更新日期：2013-01-02 00:00:00

abstract：:The Galápagos Islands are known to have experienced significant drought during the Quaternary. The loss of mesophytic upland habitats has been suggested to underlie the relatively lower endemism of upland compared with lowland plant assemblages. A fossil pollen record spanning the last 26,000 years from an upland bog ...

journal_title：Frontiers in genetics

authors： Collins AF,Bush MB,Sachs JP

更新日期：2013-12-03 00:00:00

abstract：:In the last few years, the role of non-coding regulatory elements and their involvement in human disease have received great attention. Among the non-coding regulatory sequences, enhancers are particularly important for the proper establishment of cell type-specific gene-expression programs. Furthermore, the disruptio...

journal_title：Frontiers in genetics

authors： Sánchez-Gaya V,Mariner-Faulí M,Rada-Iglesias A

更新日期：2020-07-20 00:00:00

abstract：:Some candidate genes have been robustly reported to be associated with complex traits, such as the fat mass and obesity-associated (FTO) gene on body mass index (BMI), and the fibroblast growth factor 5 (FGF5) gene on blood pressure levels. It is of interest to know whether an environmental factor (E) can attenuate or...

journal_title：Frontiers in genetics

authors： Lin WY,Lin YS,Chan CC,Liu YL,Tsai SJ,Kuo PH

更新日期：2020-05-08 00:00:00

abstract：:Ubiquitination is a reversible protein modification broadly implicated in cellular functions. Signaling processes mediated by ubiquitin (ub) are crucial for the cellular response to DNA double-strand breaks (DSBs), one of the most dangerous types of DNA lesions. In particular, the DSB response critically relies on act...

journal_title：Frontiers in genetics

authors： Citterio E

更新日期：2015-09-08 00:00:00

abstract：:Extracting inherent valuable knowledge from omics big data remains as a daunting problem in bioinformatics and computational biology. Deep learning, as an emerging branch from machine learning, has exhibited unprecedented performance in quite a few applications from academia and industry. We highlight the difference a...

journal_title：Frontiers in genetics

authors： Tang B,Pan Z,Yin K,Khateeb A

更新日期：2019-03-26 00:00:00

abstract：:Over the past decade, neural networks have become one of the cutting-edge methods in various research fields, outshining specifically in complex classification problems. In this paper, we propose two main contributions: first, we conduct a methodological study of neural network modeling for classifying biological trai...

journal_title：Frontiers in genetics

authors： Wilentzik Müller R,Gat-Viks I

更新日期：2020-05-15 00:00:00

abstract：:MicroRNAs (miRNAs) undergo high levels of regulation in skeletal muscle development and control skeletal muscle mass, function and metabolism over the lifespan. More recently, the role of long non-coding RNAs (lncRNAs) in skeletal muscle regulation has started to emerge. Following up on our recent study describing the...

journal_title：Frontiers in genetics

authors： Mikovic J,Sadler K,Butchart L,Voisin S,Gerlinger-Romero F,Della Gatta P,Grounds MD,Lamon S

更新日期：2018-11-16 00:00:00

abstract：:The availability of massive amounts of DNA sequence data, from 1000s of genomes even in a single project has had a huge impact on our understanding of biology, but also creates several problems for biologists carrying out those experiments. Bioinformatic analysis of sequence data is perhaps the most obvious challenge ...

journal_title：Frontiers in genetics

authors： Hadfield J,Eldridge MD

更新日期：2014-02-20 00:00:00

abstract：:Posttraumatic Stress Disorder (PTSD) is a complex illness, frequently co-morbid with depression, caused by both genetics, and the environment. Alcohol Use Disorder (AUD), which also co-occurs with depression, is often co-morbid with PTSD. To date, very few genes have been identified for PTSD and even less for PTSD com...

journal_title：Frontiers in genetics

authors： Lim PH,Shi G,Wang T,Jenz ST,Mulligan MK,Redei EE,Chen H

更新日期：2018-11-27 00:00:00

abstract：:Cereals are a staple food for many people around the world; however, they are also a major dietary source of toxic metal(loid)s. Many agricultural regions throughout the world are contaminated with toxic metal(loid)s, which can accumulate to high levels in the grains of cereals cultivated in these regions, posing seri...

journal_title：Frontiers in genetics

authors： Deng F,Yu M,Martinoia E,Song WY

更新日期：2019-04-09 00:00:00

abstract：:The phenotype of carcass traits in beef cattle are affected by random genetic and non-genetic effects, which both can be modulated by an environmental variable such as Temperature-Humidity Index (THI), a key environmental factor in cattle production. In this study, a multivariate reaction norm model (MRNM) was used to...

journal_title：Frontiers in genetics

authors： Chung Y,Lee SH,Lee HK,Lim D,van der Werf J,Lee SH

更新日期：2020-12-23 00:00:00

abstract：:Goats (Capra hircus) are an economically important livestock species providing meat and milk across the globe. They are of particular importance in tropical agri-systems contributing to sustainable agriculture, alleviation of poverty, social cohesion, and utilisation of marginal grazing. There are excellent genetic an...

journal_title：Frontiers in genetics

authors： Muriuki C,Bush SJ,Salavati M,McCulloch MEB,Lisowski ZM,Agaba M,Djikeng A,Hume DA,Clark EL

更新日期：2019-11-04 00:00:00

abstract：:The increased feasibility of whole-genome (or whole-exome) sequencing has led to renewed interest in using family data to find disease mutations. For clinical phenotypes that lend themselves to study in large families, this approach can be particularly effective, because it may be possible to obtain strong evidence of...

journal_title：Frontiers in genetics

authors： Huang Y,Thomas A,Vieland VJ

更新日期：2013-04-19 00:00:00

abstract：:The primary function of leaves is to provide an interface between plants and their environment for gas exchange, light exposure and thermoregulation. Leaves have, therefore a central contribution to plant fitness by allowing an efficient absorption of sunlight energy through photosynthesis to ensure an optimal growth....

journal_title：Frontiers in genetics

authors： Fritz MA,Rosa S,Sicard A

更新日期：2018-10-24 00:00:00

abstract：:One of the challenges in the analysis of large data sets, particularly in a population-based setting, is the ability to perform comparisons across projects. This has to be done in such a way that the integrity of each individual project is maintained, while ensuring that the data are comparable across projects. These ...

journal_title：Frontiers in genetics

authors： Fejes AP,Jones MJ,Kobor MS

更新日期：2014-09-18 00:00:00

abstract：:Most cell functions are carried out by interacting factors, thus underlying the functional importance of genetic interactions between genes, termed epistasis. Epistasis could be under strong selective pressures especially in conditions where the mutation rate of one of the interacting partners notably differs from the...

journal_title：Frontiers in genetics

authors： Levin L,Blumberg A,Barshad G,Mishmar D

更新日期：2014-12-23 00:00:00

abstract：:Human T-lymphotropic virus 1 (HTLV-1) was the first human retrovirus to be discovered and is the causative agent of adult T-cell leukemia/lymphoma (ATL) and the neurodegenerative disease HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). The importance of microRNA (miRNA) in the replicative cycle of ...

journal_title：Frontiers in genetics

authors： Sampey GC,Van Duyne R,Currer R,Das R,Narayanan A,Kashanchi F

更新日期：2012-12-17 00:00:00

abstract：:Livestock conservation practice is changing rapidly in light of policy developments, climate change and diversifying market demands. The last decade has seen a step change in technology and analytical approaches available to define, manage and conserve Farm Animal Genomic Resources (FAnGR). However, these rapid change...

journal_title：Frontiers in genetics

authors： Bruford MW,Ginja C,Hoffmann I,Joost S,Orozco-terWengel P,Alberto FJ,Amaral AJ,Barbato M,Biscarini F,Colli L,Costa M,Curik I,Duruz S,Ferenčaković M,Fischer D,Fitak R,Groeneveld LF,Hall SJ,Hanotte O,Hassan FU,Helsen

更新日期：2015-10-21 00:00:00

abstract：BACKGROUND:Schizophrenia is a complex psychiatric disorder with a lifetime morbidity rate of 0.5-1.0%. The pathophysiology of schizophrenia still remains obscure. Accumulating evidence indicates that DNA methylation, which is the addition of a methyl group to the cytosine in a CpG dinucleotide, might play an important ...

journal_title：Frontiers in genetics

authors： Numata S,Ye T,Herman M,Lipska BK

更新日期：2014-08-26 00:00:00

abstract：:RNA binding proteins (RBPs) play a key role in post-transcriptional gene regulation. They have been shown to be dysfunctional in a variety of cancers and are closely related to the occurrence and progression of cancers. However, the biological function and clinical significance of RBPs in clear cell renal carcinoma (c...

journal_title：Frontiers in genetics

authors： Wu Y,Wei X,Feng H,Hu B,Liu B,Luan Y,Ruan Y,Liu X,Liu Z,Wang S,Liu J,Wang T

更新日期：2021-01-07 00:00:00