Abstract:
PURPOSE:For glioblastoma (GBM), imaging response (IR) or pseudoprogression (PSP) is frequently observed after chemoradiation and may connote a favorable prognosis. With tumors categorized by the Cancer Genome Atlas Project (mesenchymal, classical, neural, and proneural) and by methylguanine-methyltransferase (MGMT) methylation status, we attempted to determine if certain genomic or molecular subtypes of GBM were specifically associated with IR or PSP. METHODS:Patients with GBM treated at two institutions were reviewed. Kaplan-Meier method was used to estimate overall survival (OS) and progression-free survival (PFS). Mantel-cox test determined effect of IR and PSP on OS and PFS. Fisher's exact test was utilized to correlate IR and PSP with genomic subtypes and MGMT status. RESULTS:Eighty-two patients with GBM were reviewed. The median OS and PFS were 17.9 months and 8.9 months. IR was observed in 28 (40%) and was associated with improved OS (median 29.4 vs 14.5 months p < 0.01) and PFS (median 17.7 vs 5.5 months, p < 0.01). PSP was observed in 14 (19.2%) and trended towards improved PFS (15.0 vs 7.7 months p = 0.08). Tumors with a proneural component had a higher rate of IR compared to those without a proneural component (IR 60% vs 28%; p = 0.03). MGMT methylation was associated with IR (58% vs 24%, p = 0.032), but not PSP (34%, p = 0.10). CONCLUSION:IR is associated with improved OS and PFS. The proneural subtype and MGMT methylated tumors had higher rates of IR.
journal_name
Neuroradiologyjournal_title
Neuroradiologyauthors
Soike MH,McTyre ER,Shah N,Puchalski RB,Holmes JA,Paulsson AK,Miller LD,Cramer CK,Lesser GJ,Strowd RE,Hinson WH,Mott RT,Johnson AJ,Lo HW,Laxton AW,Tatter SB,Debinski W,Chan MDdoi
10.1007/s00234-018-2060-ysubject
Has Abstractpub_date
2018-10-01 00:00:00pages
1043-1051issue
10eissn
0028-3940issn
1432-1920pii
10.1007/s00234-018-2060-yjournal_volume
60pub_type
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