In vitro delineation of human brain-stem anatomy using a small resonator: correlation with macroscopic and histological findings.

Abstract:

:Our purpose was to investigate the potential of an experimental animal coil using a commercial MRI unit to delineate the anatomical structure of the human brain stem. Three formaldehyde-fixed brain-stem specimens were examined by MRI and sectioned perpendicular to their longitudinal axis. The images were compared with gross anatomy and myelin-stained histological sections. Fibre tracts and nuclei which were not evident on examination of the unstained specimen were readily identified by MRI. Due to its inherent grey/white matter contrast, MRI with a high-resolution coil delineates anatomical structures in a way comparable to the myelin-stained histological sections. However, pigmented structures, readily visible on examination of the unstained specimen were discernible on neither MRI nor on myelin-stained sections. The excellent anatomical detail and grey/white matter contrast provided by these images could make MRI a useful adjunct to the pathologist investigating brain disease.

journal_name

Neuroradiology

journal_title

Neuroradiology

authors

Mäurer J,Mitrovic T,Knollmann FD,Lüdtke E,Requardt H

doi

10.1007/BF00596532

subject

Has Abstract

pub_date

1996-04-01 00:00:00

pages

217-20

issue

3

eissn

0028-3940

issn

1432-1920

journal_volume

38

pub_type

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