FADS1 and the Timing of Human Adaptation to Agriculture.

abstract：:The mitochondrial inner and outer membranes are composed of a variety of integral membrane proteins, assembled into the membranes posttranslationally. The small translocase of the inner mitochondrial membranes (TIMs) are a group of approximately 10 kDa proteins that function as chaperones to ferry the imported protein...

journal_title：Molecular biology and evolution

authors： Gentle IE,Perry AJ,Alcock FH,Likić VA,Dolezal P,Ng ET,Purcell AW,McConnville M,Naderer T,Chanez AL,Charrière F,Aschinger C,Schneider A,Tokatlidis K,Lithgow T

更新日期：2007-05-01 00:00:00

abstract：:C repeats constitute the predominant family of short interspersed repeats (SINEs) in the rabbit genome. Determination of the nucleotide sequence 5' to rabbit zeta-globin genes reveals clusters of C repeats, and analysis of these and other sequenced regions of rabbit chromosomes shows that the C repeats have a strong t...

journal_title：Molecular biology and evolution

authors： Krane DE,Clark AG,Cheng JF,Hardison RC

更新日期：1991-01-01 00:00:00

abstract：:The acquisition of photosynthesis by eukaryotic cells through enslavement of a cyanobacterium represents one of the most remarkable turning points in the history of life on Earth. In addition to endosymbiotic gene transfer, the acquisition of a protein import apparatus and the coordination of gene expression between h...

journal_title：Molecular biology and evolution

authors： Colleoni C,Linka M,Deschamps P,Handford MG,Dupree P,Weber AP,Ball SG

更新日期：2010-12-01 00:00:00

abstract：:Maximum likelihood codon substitution models have proven useful for studying when and how protein function evolves, but they have recently been criticized on a number of fronts. The strengths and weaknesses of such methods must therefore be identified and improved upon. Here, using simulations, we show that the Clade ...

journal_title：Molecular biology and evolution

authors： Weadick CJ,Chang BS

更新日期：2012-05-01 00:00:00

abstract：:Human DNA variation is currently a subject of intense research because of its importance for studying human origins, evolution, and demographic history and for association studies of complex diseases. A approximately 10-kb region on chromosome 1, which contains only four small exons (each <155 bp), was sequenced for 6...

journal_title：Molecular biology and evolution

authors： Yu N,Zhao Z,Fu YX,Sambuughin N,Ramsay M,Jenkins T,Leskinen E,Patthy L,Jorde LB,Kuromori T,Li WH

更新日期：2001-02-01 00:00:00

abstract：:Parasites sometimes expand their host range by acquiring a new host species. After a host change event, the selective regime acting on a given parasite gene may change as a result of host-specific adaptive alterations of protein functionality or host-specific immune-mediated selection. We present a codon-based model t...

journal_title：Molecular biology and evolution

authors： Forsberg R,Christiansen FB

更新日期：2003-08-01 00:00:00

abstract：:The variation of amino acid substitution rates in proteins depends on several variables. Among these, the protein's expression level, functional category, essentiality, or metabolic costs of its amino acid residues may play an important role. However, the relative importance of each variable has not yet been evaluated...

journal_title：Molecular biology and evolution

authors： Rocha EP,Danchin A

更新日期：2004-01-01 00:00:00

abstract：:The human genome is divided into isochores, large stretches (>300 kb) of genomic DNA with more or less consistent GC content. Mutational/neutralist and selectionist models have been put forward to explain their existence. A major criticism of the mutational models is that they cannot account for the higher GC content ...

journal_title：Molecular biology and evolution

authors： Duret L,Hurst LD

更新日期：2001-05-01 00:00:00

abstract：:Insertion and deletion (indel)-based analyses have great potential for rooting the tree of life, but their use has been limited because they require ubiquitous sequences that have not been horizontally/laterally transferred. Very few such sequences exist. Here we describe and demonstrate a new algorithm that can use n...

journal_title：Molecular biology and evolution

authors： Lake JA,Herbold CW,Rivera MC,Servin JA,Skophammer RG

更新日期：2007-01-01 00:00:00

abstract：:The spacer between the 16S and 23S rRNA genes of the chloroplast DNA has been implicated as an origin of replication in several species of plants. In the evening primrose, Oenothera, this site was found to vary greatly in size, with plastid genomes (plastomes) being readily distinguished. To determine whether plastome...

journal_title：Molecular biology and evolution

authors： Sears BB,Stoike LL,Chiu WL

更新日期：1996-07-01 00:00:00

abstract：:ModelTest-NG is a reimplementation from scratch of jModelTest and ProtTest, two popular tools for selecting the best-fit nucleotide and amino acid substitution models, respectively. ModelTest-NG is one to two orders of magnitude faster than jModelTest and ProtTest but equally accurate and introduces several new featur...

journal_title：Molecular biology and evolution

authors： Darriba D,Posada D,Kozlov AM,Stamatakis A,Morel B,Flouri T

更新日期：2020-01-01 00:00:00

abstract：:Inactivation of the X chromosome in the male germ line has been suggested to contribute to the excess of gene movement off the X chromosome and the paucity of X-linked male-biased genes that have been observed in Drosophila species. Recent experimental work has demonstrated the transcriptional inactivation of the X ch...

journal_title：Molecular biology and evolution

authors： Kemkemer C,Hense W,Parsch J

更新日期：2011-05-01 00:00:00

abstract：:The giant extracellular hexagonal bilayer hemoglobin (HBL-Hb) of the deep-sea hydrothermal vent tube worm Riftia pachyptila is able to transport simultaneously O(2) and H(2)S in the blood from the gills to a specific organ: the trophosome that harbors sulfide-oxidizing endosymbionts. This vascular HBL-Hb is made of 14...

journal_title：Molecular biology and evolution

authors： Bailly X,Jollivet D,Vanin S,Deutsch J,Zal F,Lallier F,Toulmond A

更新日期：2002-09-01 00:00:00

abstract：:DNA polymerase γ is a family A DNA polymerase responsible for the replication of mitochondrial DNA in eukaryotes. The origins of DNA polymerase γ have remained elusive because it is not present in any known bacterium, though it has been hypothesized that mitochondria may have inherited the enzyme by phage-mediated non...

journal_title：Molecular biology and evolution

authors： Chan YW,Mohr R,Millard AD,Holmes AB,Larkum AW,Whitworth AL,Mann NH,Scanlan DJ,Hess WR,Clokie MR

更新日期：2011-08-01 00:00:00

abstract：:High-affinity antibodies arise within weeks of infection from the evolution of B-cell receptors under selection to improve antigen recognition. This rapid adaptation is enabled by the distribution of highly mutable "hotspot" motifs in B-cell receptor genes. High mutability in antigen-binding regions (complementarity d...

journal_title：Molecular biology and evolution

authors： Vieira MC,Zinder D,Cobey S

更新日期：2018-05-01 00:00:00

abstract：:The complete nucleotide sequence of the mt (mitochondrial) and cp (chloroplast) genomes of the unicellular green alga Ostreococcus tauri has been determined. The mt genome assembles as a circle of 44,237 bp and contains 65 genes. With an overall average length of only 42 bp for the intergenic regions, this is the most...

journal_title：Molecular biology and evolution

authors： Robbens S,Derelle E,Ferraz C,Wuyts J,Moreau H,Van de Peer Y

更新日期：2007-04-01 00:00:00

abstract：:Serum response factor (SRF) and myocyte enhancer factor 2 (MEF2) represent two types of members of the MCM1, AGAMOUS, DEFICIENS, and SRF (MADS)-box transcription factor family present in animals and fungi. Each type has distinct biological functions, which are reflected by the distinct specificities of the proteins bo...

journal_title：Molecular biology and evolution

authors： Wu W,Huang X,Cheng J,Li Z,de Folter S,Huang Z,Jiang X,Pang H,Tao S

更新日期：2011-01-01 00:00:00

abstract：:Disease response genes (DRGs) diverge under recurrent positive selection as a result of a molecular arms race between hosts and pathogens. Most of these studies were conducted in animals, and few defense genes have been shown to evolve adaptively in plants. To test for adaptation in the molecules mediating disease res...

journal_title：Molecular biology and evolution

authors： Zamora A,Sun Q,Hamblin MT,Aquadro CF,Kresovich S

更新日期：2009-09-01 00:00:00

abstract：:A simple model for the evolution of the rate of molecular evolution is presented. With a Bayesian approach, this model can serve as the basis for estimating dates of important evolutionary events even in the absence of the assumption of constant rates among evolutionary lineages. The method can be used in conjunction ...

journal_title：Molecular biology and evolution

authors： Thorne JL,Kishino H,Painter IS

更新日期：1998-12-01 00:00:00

abstract：:This study examines molecular relationships across a wide range of species in the mass spawning scleractinian coral genus Acropora. Molecular phylogenies were obtained for 28 species using DNA sequence analyses of two independent markers, a nuclear intron and the mtDNA putative control region. Although the composition...

journal_title：Molecular biology and evolution

authors： van Oppen MJ,McDonald BJ,Willis B,Miller DJ

更新日期：2001-07-01 00:00:00

abstract：:Multiple haplotypes from each of three nuclear loci were isolated and sequenced from geographic populations of the American oyster, Crassostrea virginica. In tests of alternative phylogeographic hypotheses for this species, nuclear gene genealogies constructed for these haplotypes were compared to one another, to a mi...

journal_title：Molecular biology and evolution

authors： Hare MP,Avise JC

更新日期：1998-02-01 00:00:00

abstract：:A labeled gene tree topology that is more probable than the labeled gene tree topology matching a species tree is called "anomalous." Species trees that can generate such anomalous gene trees are said to be in the "anomaly zone." Here, probabilities of "unranked" and "ranked" gene tree topologies under the multispecie...

journal_title：Molecular biology and evolution

authors： Kim A,Rosenberg NA,Degnan JH

更新日期：2020-05-01 00:00:00

abstract：:Estimation of evolutionary distances from coding sequences must take into account protein-level selection to avoid relative underestimation of longer evolutionary distances. Current modeling of selection via site-to-site rate heterogeneity generally neglects another aspect of selection, namely position-specific amino ...

journal_title：Molecular biology and evolution

authors： Halpern AL,Bruno WJ

更新日期：1998-07-01 00:00:00

abstract：:In the age of whole-genome population genetics, so-called genomic scan studies often conclude with a long list of putatively selected loci. These lists are then further scrutinized to annotate these regions by gene function, corresponding biological processes, expression levels, or gene networks. Such annotations are ...

journal_title：Molecular biology and evolution

authors： Pavlidis P,Jensen JD,Stephan W,Stamatakis A

更新日期：2012-10-01 00:00:00

abstract：:The Environment for Tree Exploration (ETE) is a computational framework that simplifies the reconstruction, analysis, and visualization of phylogenetic trees and multiple sequence alignments. Here, we present ETE v3, featuring numerous improvements in the underlying library of methods, and providing a novel set of sta...

journal_title：Molecular biology and evolution

authors： Huerta-Cepas J,Serra F,Bork P

更新日期：2016-06-01 00:00:00

abstract：:With growing amounts of genome data and constant improvement of models of molecular evolution, phylogenetic reconstruction became more reliable. However, our knowledge of the real process of molecular evolution is still limited. When enough large-sized data sets are analyzed, any subtle biases in statistical models ca...

journal_title：Molecular biology and evolution

authors： Kitazoe Y,Kishino H,Okabayashi T,Watabe T,Nakajima N,Okuhara Y,Kurihara Y

更新日期：2005-03-01 00:00:00

abstract：:Modifications to transcriptional regulators play a major role in adaptation. Here, we compared the effects of multiple beneficial mutations within and between Escherichia coli rpoB, the gene encoding the RNA polymerase β subunit, and rho, which encodes a transcriptional terminator. These two genes have harbored adapti...

journal_title：Molecular biology and evolution

authors： González-González A,Hug SM,Rodríguez-Verdugo A,Patel JS,Gaut BS

更新日期：2017-11-01 00:00:00

abstract：:This study establishes a phylogenetic framework for the natural geographic isolates of the widely studied nematode species Caenorhabditis elegans. Virtually complete mitochondrial genomes are sequenced from 27 C. elegans natural isolates to characterize mitochondrial divergence patterns and to investigate the evolutio...

journal_title：Molecular biology and evolution

authors： Denver DR,Morris K,Thomas WK

更新日期：2003-03-01 00:00:00

abstract：:Some genes have repeatedly been found to control diverse adaptations in a wide variety of organisms. Such gene reuse reveals not only the diversity of phenotypes these unique genes control but also the composition of developmental gene networks and the genetic routes available to and taken by organisms during adaptati...

journal_title：Molecular biology and evolution

authors： VanKuren NW,Massardo D,Nallu S,Kronforst MR

更新日期：2019-12-01 00:00:00

abstract：:Inferring past population dynamics over time from heterochronous molecular sequence data is often achieved using the Bayesian Skygrid model, a non-parametric coalescent model that estimates the effective population size over time. Available in BEAST, a cross-platform program for Bayesian analysis of molecular sequence...

journal_title：Molecular biology and evolution

authors： Hill V,Baele G

更新日期：2019-07-31 00:00:00