Vitamin D supplementation and muscle strength in pre-sarcopenic elderly Lebanese people: a randomized controlled trial.


:Previous studies have shown that improving vitamin D status among the elderly may lead to an improvement in muscle mass and muscle strength. In our study, vitamin D supplementation showed significant improvements in vitamin D concentrations as well as appendicular muscle mass in pre-sarcopenic older Lebanese people. However, we found no significant effect on muscle strength. INTRODUCTION:Improving vitamin D status might improve muscle function and muscle mass that lead to sarcopenia in older subjects. The aim of this randomized, controlled, double-blind study was to examine the effect of vitamin D supplementation on handgrip strength and appendicular skeletal muscle mass in pre-sarcopenic older Lebanese subjects. We also examined whether this effect differs in normal vs. obese subjects. METHODS:Participants (n = 128; 62 men and 66 women) deficient in vitamin D (25(OH)D = 12.92 ± 4.3 ng/ml) were recruited from Saint Charles Hospital, Beirut, Lebanon. The participants were given a supplement of 10,000 IU of cholecalciferol (vitamin D group; n = 64) to be taken three times a week or a placebo tablet (placebo group; n = 64) for 6 months. One hundred fifteen subjects completed the study: 59 had normal weight, while 56 were obese. Strength and functional assessment and biochemical analysis were performed at the start and after 6 months. RESULTS:Compared to placebo, the vitamin D supplemented group showed significant improvements in appendicular skeletal muscle mass (ASMM) (P < 0.001) but not in handgrip strength (P = 0.2901). ANCOVA for ASMM adjusting for obesity and including the interaction between obesity and vitamin D showed a significant interaction. The increase in ASMM with vitamin D in normal-weight subjects was higher than that of obese subjects (B = 35.09 vs. B = 2.19). CONCLUSION:Treatment with vitamin D showed beneficial effects on appendicular muscle mass in pre-sarcopenic older Lebanese men and women. However, it had no effect on muscle strength relative to placebo. This trial was registered at as ISRCTN16665940.


Arch Osteoporos


Archives of osteoporosis


El Hajj C,Fares S,Chardigny JM,Boirie Y,Walrand S




Has Abstract


2018-12-19 00:00:00














  • Retraction Note to: Secular trends in major osteoporotic fractures among 50+ adults in Denmark between 1995 and 2010.

    abstract::The publisher has retracted this article [1] from Archives of Osteoporosis in order to publish in Osteoporosis International as originally intended by the authors and the Editors of Osteoporosis International. Springer Nature apologizes to readers and the authors. ...

    journal_title:Archives of osteoporosis

    pub_type: 已发布勘误,撤回出版物


    authors: Abtahi S,Driessen JHM,Vestergaard P,van den Bergh J,Boonen A,de Vries F,Burden AM

    更新日期:2019-07-08 00:00:00

  • Restricting vitamin A intake increases bone formation in Zambian children with high liver stores of vitamin.

    abstract::This analysis was performed in Zambian children who had a high prevalence of hypervitaminosis A, defined as > 1.0 μmol retinol/g liver. Bone parameters included markers of bone formation (P1NP), bone resorption (CTX), parathyroid hormone, calcium, vitamin A, and vitamin D. Low dietary vitamin A intake increased P1NP. ...

    journal_title:Archives of osteoporosis

    pub_type: 杂志文章


    authors: Tanumihardjo SA,Gannon BM,Kaliwile C,Chileshe J,Binkley NC

    更新日期:2019-06-28 00:00:00

  • Chinese patients' preference for pharmaceutical treatments of osteoporosis: a discrete choice experiment.

    abstract::While adherence to osteoporosis treatment is low, patients' preference for osteoporosis treatment is unknown in Chinese patients. Chinese patients are willing to receive treatments with higher clinical efficacy and lower out-of-pocket cost. In addition, annual intravenous infusion and 6-month subcutaneous injection ar...

    journal_title:Archives of osteoporosis

    pub_type: 杂志文章


    authors: Si L,Tu L,Xie Y,Palmer AJ,Gu Y,Zheng X,Li J,Lv Q,Qi J,Lin Z,Chen M,Gu J,Hiligsmann M

    更新日期:2019-07-31 00:00:00

  • Infiltrating giant cell tumor in a case of Paget's disease of bone.

    abstract::Giant cell tumor (GCT) of the bone, also called osteoclastoma, is a rare complication of Paget's bone disease. We report a patient from Southern Italy who developed a GCT infiltrating the neighboring tissues. The natural history and the therapeutic outcomes of this unique complication of Paget's bone disease are prese...

    journal_title:Archives of osteoporosis

    pub_type: 杂志文章


    authors: Nuzzo V,Ferrara T,Zuccoli A,Brunetti-Pierri R,De Rosa R,Falchetti A,Franco R,Brunetti-Pierri N

    更新日期:2009-12-01 00:00:00

  • Differing impact of clinical factors on the risk of fracture in younger and older women in the general population and an osteoporosis clinic population.

    abstract::This study assesses the impact of risk factors for fracture in women aged 80+ and 60-79. The results suggest that risk assessment which fits younger women may not be suited for the 80+ strata as many common risk factors are less predictive in the older compared to the younger cohort. PURPOSE:This study assesses wheth...

    journal_title:Archives of osteoporosis

    pub_type: 杂志文章


    authors: Lauppe R,Åkesson KE,Ljunggren Ö,Spångéus A,Ortsäter G,Feudjo-Tepie M,Ström O

    更新日期:2019-04-08 00:00:00

  • Trabecular bone score (TBS) and bone mineral density in patients with long-term therapy with warfarin.

    abstract::In this study, we compared patients using the anticoagulant warfarin for more than a year with a control group with similar characteristics but without using the drug. We demonstrated worse BMD and bone quality by trabecular bone score (TBS) in patients using warfarin for more than 1 year. PURPOSE:Evaluate the bone m...

    journal_title:Archives of osteoporosis

    pub_type: 杂志文章


    authors: Marques JVO,Nalevaiko JZ,Oliveira MF,Raetsch AWP,Marques GL,Petterle RR,Moreira CA,Borba VZC

    更新日期:2020-07-06 00:00:00

  • Management of osteoporosis in the Middle East and North Africa: a survey of physicians' perceptions and practices.

    abstract::We surveyed 573 physicians in the Middle East regarding osteoporosis management. Sixty percent had access to, but were not in charge of, densitometry reporting. Screening for secondary causes was common; 62% were aware of FRAX®; less than half used it. Medications were accessible, and most participants had concerns re...

    journal_title:Archives of osteoporosis

    pub_type: 杂志文章


    authors: Beshyah SA,Al-Saleh Y,El-Hajj Fuleihan G

    更新日期:2019-06-07 00:00:00

  • Health care costs of osteopenia, osteoporosis, and fragility fractures in Mexico.

    abstract:UNLABELLED:Different sources were used to estimate the 2010 health care costs of managing low bone density (osteopenia/osteoporosis) plus caring fragility fractures in Mexico at 411 million USD. Figures are projected to rise 42 % by 2020. Preventive and timely interventions are required to decrease the financial burden...

    journal_title:Archives of osteoporosis

    pub_type: 杂志文章


    authors: Carlos F,Clark P,Galindo-Suárez RM,Chico-Barba LG

    更新日期:2013-01-01 00:00:00

  • Bone mineral density among Palestinian patients suffering from hemoglobinopathy disorders.

    abstract::This study aimed to investigate the correlation between bone mineral density (BMD) with hemoglobin and ferritin levels in Palestinian patients suffering from various types of hemoglobinopathies. The study revealed the thresholds of hemoglobin and ferritin to protect against low BMD in these patients. PURPOSE:Iron ove...

    journal_title:Archives of osteoporosis

    pub_type: 杂志文章


    authors: Kharroubi A,Karmi B,Shamasneh W,Saba E

    更新日期:2020-11-13 00:00:00

  • Automated quantitative morphometry of vertebral heights on spinal radiographs: comparison of a clinical workflow tool with standard 6-point morphometry.

    abstract::A workflow tool for measurements of vertebral heights on lateral spine radiographs based on automated placements of 6 points per vertebra was evaluated. The tool helps to standardize point placement among operators. Its success rate is very good in normal vertebrae but lower in vertebrae with more severe fractures. Ma...

    journal_title:Archives of osteoporosis

    pub_type: 杂志文章


    authors: Engelke K,Stampa B,Steiger P,Fuerst T,Genant HK

    更新日期:2019-02-11 00:00:00

  • Correction to: Comparison of hip subregion bone mineral density to the type of proximal femur fracture.

    abstract::The original version of this article, published on 05 August 2020, unfortunately contained a mistake. ...

    journal_title:Archives of osteoporosis

    pub_type: 杂志文章,已发布勘误


    authors: Cho Y,Lee I,Ha SH,Park JH,Park JH

    更新日期:2020-09-08 00:00:00

  • Difference of clinical course between cases with bone union and those with delayed union following osteoporotic vertebral fractures.

    abstract::In this prospective multicenter study of osteoporotic vertebral fractures (OVFs), delayed union of OVF at 6-month follow-up caused prolonged pain, QOL impairment, ADL impairment, cognitive status deterioration, and vertebral collapse progression. PURPOSE:Delayed union following osteoporotic vertebral fracture display...

    journal_title:Archives of osteoporosis

    pub_type: 杂志文章,多中心研究


    authors: Yasuda H,Hoshino M,Tsujio T,Terai H,Namikawa T,Kato M,Matsumura A,Suzuki A,Takayama K,Takahashi S,Nakamura H

    更新日期:2017-12-28 00:00:00

  • Social inequalities in osteoporosis and fracture among community-dwelling older men and women: findings from the Hertfordshire Cohort Study.

    abstract:UNLABELLED:It is unknown whether osteoporosis is socially patterned. Using data from the Hertfordshire Cohort Study we found no consistent evidence for social inequalities in prevalent or incident fracture, bone mineral density or loss rates, or bone strength. Public health strategies for prevention of osteoporosis sho...

    journal_title:Archives of osteoporosis

    pub_type: 杂志文章


    authors: Syddall HE,Evandrou M,Dennison EM,Cooper C,Sayer AA

    更新日期:2012-01-01 00:00:00

  • Multiple vertebral fractures sustained 5 months after Roux-en-Y gastric bypass: a case report.

    abstract:INTRODUCTION:We report a case of a patient sustaining multiple simultaneous vertebral fractures 5 months after Roux-en-Y gastric bypass (RYGB) surgery. Obesity is associated with increased rates of morbidity and mortality and obesity rates globally continue to rise. Bariatric surgical procedures are successful in induc...

    journal_title:Archives of osteoporosis

    pub_type: 杂志文章


    authors: Higgins SC,Papasavvas G

    更新日期:2018-05-02 00:00:00

  • Pre-fracture hospitalization is associated with worse functional outcome and higher mortality in geriatric hip fracture patients.

    abstract::Hip fractures are common in elderly people. Despite great progress in surgical care, the outcomes of these patients remain disappointing. This study determined pre-fracture hospital admission as a prognostic variable for inferior functional outcomes and increased mortality rates in the perioperative phase and in the f...

    journal_title:Archives of osteoporosis

    pub_type: 杂志文章


    authors: Aigner R,Buecking B,Hack J,Eschbach D,Oberkircher L,Ruchholtz S,Bliemel C

    更新日期:2017-12-01 00:00:00

  • The consistency of care for older patients with a hip fracture: are the results of the integrated orthogeriatric treatment model of the Centre of Geriatric Traumatology consistent 10 years after implementation?

    abstract::In the past 10 years after implementation, the orthogeriatric treatment model led in general to consistent outcomes for 1555 older adults in terms of most of the complications and mortality. Surgery was more often delayed to 24-48 h after arrival at the hospital, while the length of hospital stay shortened. INTRODUCT...

    journal_title:Archives of osteoporosis

    pub_type: 杂志文章


    authors: Nijmeijer WS,Folbert EC,Vermeer M,Vollenbroek-Hutten MMR,Hegeman JH

    更新日期:2018-11-19 00:00:00

  • Management of osteoporosis in central and eastern Europe (CEE): conclusions of the "2nd Summit on Osteoporosis-CEE", 21-22 November 2008, Warsaw, Poland.

    abstract::In November 2008, the "2nd Summit on Osteoporosis-Central and Eastern Europe (CEE)" was held in Warsaw, Poland. Discussions at this meeting focused on the identification and discussion of diagnostic, preventive, and therapeutic measures used in CEE. Evaluated information was used to identify issues regarding diagnosis...

    journal_title:Archives of osteoporosis

    pub_type: 杂志文章


    authors: Lorenc RS,Resch H,on behalf of the Members of the “2nd Summit on Osteoporosis—Central and Eastern Europe (CEE)”.

    更新日期:2009-12-01 00:00:00

  • Humeral fractures due to low-energy trauma: an epidemiological survey in patients referred to a large emergency department in Northern Italy.

    abstract:UNLABELLED:This survey describes the epidemiology of approximately 1800 low-energy humeral fractures seen in a large emergency department in Northern Italy over 7 years (2007-2013), highlighting the differences from previous Italian studies. PURPOSE:The purpose of this study was to determine the incidence of humeral f...

    journal_title:Archives of osteoporosis

    pub_type: 杂志文章


    authors: Pedrazzoni M,Abbate B,Verzicco I,Pedrazzini A,Benatti M,Cervellin G

    更新日期:2015-01-01 00:00:00

  • Prevalence of osteoporosis with the World Health Organization diagnostic criteria in the Eastern Mediterranean Region: a systematic review and meta-analysis.

    abstract::A systematic review and meta-analysis was conducted on the prevalence of osteoporosis in the Eastern Mediterranean Region. The overall pooled prevalence of osteoporosis was 24.4%. The prevalence has increased significantly over the recent years. The highest pooled prevalence was in Saudi Arabia (32.7%), and the lowest...

    journal_title:Archives of osteoporosis

    pub_type: 杂志文章,meta分析


    authors: Zamani M,Zamani V,Heidari B,Parsian H,Esmaeilnejad-Ganji SM

    更新日期:2018-11-17 00:00:00

  • Long-term benefits and risks of parathyroid hormone treatment in compliant osteoporotic patients. A Danish national register based cohort study.

    abstract:PURPOSE:Medical treatment of osteoporosis should preferably be both effective and have minimal side effects. The aim of the present study was to examine long-term benefits and risks of parathyroid hormone (PTH) treatment in compliant patients. METHODS:This is a nationwide retrospective cohort study based on national r...

    journal_title:Archives of osteoporosis

    pub_type: 杂志文章


    authors: Thorsteinsson AL,Hansen L,Vestergaard P,Eiken P

    更新日期:2018-05-02 00:00:00

  • Preventing future fractures: effectiveness of an orthogeriatric fracture liaison service compared to an outpatient fracture liaison service and the standard management in patients with hip fracture.

    abstract::An observational study was carried out in two hospitals in patients > 65 years admitted for hip fracture. At 6 months, 15% of patients in the hospital with orthogeriatric standard care and 75% in the hospital with fracture liaison service were receiving bisphosphonates. PURPOSE:Many patients with fractures are discha...

    journal_title:Archives of osteoporosis

    pub_type: 杂志文章


    authors: Naranjo A,Fernández-Conde S,Ojeda S,Torres-Hernández L,Hernández-Carballo C,Bernardos I,Rodríguez S,Laynez P

    更新日期:2017-12-11 00:00:00

  • Association between diabetic neuropathy and osteoporosis in patients: a systematic review and meta-analysis.

    abstract:OBJECTIVES:Many studies have explored the association between neuropathy and osteoporosis in patients with diabetes mellitus. However, the results still remain inconsistent and controversial. We aimed to estimate the association between diabetic neuropathy and osteoporosis. METHODS:Databases, including PubMed, Embase,...

    journal_title:Archives of osteoporosis

    pub_type: 杂志文章,meta分析


    authors: Liu C,Lv H,Niu P,Tan J,Ma Y

    更新日期:2020-08-10 00:00:00

  • Normative calcaneal quantitative ultrasound data for the indigenous Shuar and non-Shuar Colonos of the Ecuadorian Amazon.

    abstract:UNLABELLED:Minimal data on bone mineral density changes are available from populations in developing countries. Using calcaneal quantitative ultrasound (QUS) techniques, the current study contributes to remedying this gap in the literature by establishing a normative data set on the indigenous Shuar and non-Shuar Colon...

    journal_title:Archives of osteoporosis

    pub_type: 杂志文章


    authors: Madimenos FC,Snodgrass JJ,Blackwell AD,Liebert MA,Cepon TJ,Sugiyama LS

    更新日期:2011-01-01 00:00:00

  • Bone mineral density, metabolic syndrome, and vitamin D in indigenous from south of Brazil.

    abstract:UNLABELLED:Bone mineral density (BMD), metabolic syndrome (MS), and vitamin D levels were evaluated in 73 indigenous from south of Brazil aged between 40 and 86 years. BMD loss in lumbar spine was detected in 63 %, MS was detected in 76.7 %, and vitamin D levels were altered in 67 % of subjects. PURPOSE:This study aim...

    journal_title:Archives of osteoporosis

    pub_type: 杂志文章


    authors: da Rocha AK,Bós AJ,Carnenaz G,Machado DC

    更新日期:2013-01-01 00:00:00

  • Diagnosis and management of vitamin D deficiency in the Gulf Cooperative Council (GCC) countries: an expert consensus summary statement from the GCC vitamin D advisory board.

    abstract:OBJECTIVE:A summary of recommendations is given within the Gulf Cooperation Council (GCC) setting on the assessment and management of vitamin D deficiency in the region. METHODS:An assembly of 11 regional experts gathered to formulate an all-inclusive approach to vitamin D deficiency within GCC. RESULTS AND CONCLUSIO...

    journal_title:Archives of osteoporosis

    pub_type: 共识发展会议,杂志文章


    authors: Al Saleh Y,Beshyah SA,Hussein W,Almadani A,Hassoun A,Al Mamari A,Ba-Essa E,Al-Dhafiri E,Hassanein M,Fouda MA,Al Ali N,Aljohani N,Al-Sayed N,Gittoes N,Elhadd T,Al-Baker W,Sabico S,Al-Daghri N

    更新日期:2020-03-02 00:00:00

  • Moderate-to-heavy smoking in women is potentially associated with compromised cortical porosity and stiffness at the distal radius.

    abstract::Though smokers have poor clinical outcomes after treatment for fractures, the skeletal effects of smoking are still debated. Our results showed that female smokers had 33% higher cortical bone porosity. Smoking targets cortical compartment microstructure and mechanics, and micron-scale variables are essential to bette...

    journal_title:Archives of osteoporosis

    pub_type: 杂志文章


    authors: Johnson JE,Troy KL

    更新日期:2018-08-23 00:00:00

  • Teriparatide treatment of femoral fracture nonunion that autogenous bone grafting failed to heal: a case report.

    abstract:PURPOSE:Management of fracture nonunion is challenging as another surgical intervention for the patient is often a necessity, which has a huge impact on both quality of life and economic burden of the patient. Thus, a less aggressive and better accepted treatment for nonunion is required. METHODS:We gave teriparatide ...

    journal_title:Archives of osteoporosis

    pub_type: 杂志文章


    authors: Yu W,Guo X

    更新日期:2017-12-01 00:00:00

  • Correction to: Estimated expenditures for hip fractures using merged healthcare insurance data for individuals aged ≥ 75 years and long-term care insurance claims data in Japan.

    abstract::The article Estimated expenditures for hip fractures using merged healthcare insurance data for individuals aged ≥ 75 years and long-term care insurance claims data in Japan. ...

    journal_title:Archives of osteoporosis

    pub_type: 已发布勘误


    authors: Mori T,Tamiya N,Jin X,Jeon B,Yoshie S,Iijima K,Ishizaki T

    更新日期:2019-02-27 00:00:00

  • Does (mis)use of industrial liquid silicone implants interfere with bone mineral density in transgender women?

    abstract::The effects of gluteal implants on bone mass remain unclear. Transgender women with ILS presented higher BMD in the hip compared with transgender women without implants, while no difference was observed in other sites. These results may be artifactual and suggest using spine/forearm sites for DXA in individuals with I...

    journal_title:Archives of osteoporosis

    pub_type: 杂志文章


    authors: Fighera TM,da Silva ED,Borba GDS,Spritzer PM

    更新日期:2020-09-22 00:00:00

  • Serum 25-hydroxy-vitamin D and the risk of fractures in the teriparatide versus risedronate VERO clinical trial.

    abstract:PURPOSE:Using data from the 2-year, randomized, double-dummy VERO trial, we examined the changes in 25-hydroxy-vitamin D (25[OH]D) concentrations over time, and whether the fracture risk reduction of teriparatide versus risedronate varies by baseline 25(OH)D sufficiency category. METHODS:Postmenopausal women with esta...

    journal_title:Archives of osteoporosis

    pub_type: 杂志文章,随机对照试验


    authors: Minisola S,Marin F,Kendler DL,Geusens P,Zerbini CAF,Russo LA,Casado E,Fahrleitner-Pammer A,Stepan JJ,Lespessailles E,Moericke R,Bagur A,Lakatos P,López-Romero P,Body JJ

    更新日期:2019-01-18 00:00:00