Abstract:
:This analysis was performed in Zambian children who had a high prevalence of hypervitaminosis A, defined as > 1.0 μmol retinol/g liver. Bone parameters included markers of bone formation (P1NP), bone resorption (CTX), parathyroid hormone, calcium, vitamin A, and vitamin D. Low dietary vitamin A intake increased P1NP. PURPOSE:Vitamin A (VA) interacts with bone health, but mechanisms require clarification. In countries where multiple interventions exist to eradicate VA deficiency, some groups are consuming excessive VA. Bone metabolism and inflammatory parameters were measured in Zambian children who had high prevalence of hypervitaminosis A determined by 13C-retinol isotope dilution. METHODS:Children (n = 143), 5 to 7 years, were recruited into a placebo-controlled biofortified orange maize feeding study for 90 days. Bone turnover (P1NP and CTX) and inflammatory (C-reactive protein (CRP) and alpha-1-acid glycoprotein) biomarkers were measured in fasting blood samples before and/or after intervention with the following: (1) VA at the recommended dietary allowance (400 μg retinol activity equivalents/day (as retinyl palmitate)), (2) maize enhanced with the provitamin A carotenoid β-carotene (2.86 mg/day), or (3) a placebo. Parathyroid hormone, calcium, and 25(OH)-vitamin D were measured at end line. RESULTS:Bone formation, as measured by P1NP, increased (P < 0.0001) in the placebo group who consumed low preformed VA during the intervention. Bone resorption, measured by CTX, was not affected. P1NP and CTX were negatively associated with inflammation, most strongly with CRP. Serum calcium did not differ among groups and was low (7.29 ± 0.87 μg/dL). Serum 25(OH) D did not differ among groups (54.5 ± 15 nmol/L), with 91% < 75 nmol/L and 38% < 50 nmol/L. CONCLUSIONS:Reduction of dietary preformed VA in Zambian children for 4 months improved bone formation. Chronic consumption of preformed VA caused hypervitaminosis A and may impair bone formation. In children, this could be associated with failure to accrue optimal peak bone mass. TRIAL REGISTRATION:The NIH Clinical Trial registry number is NCT01814891; https://clinicaltrials.gov/ct2/show/NCT01814891 .
journal_name
Arch Osteoporosjournal_title
Archives of osteoporosisauthors
Tanumihardjo SA,Gannon BM,Kaliwile C,Chileshe J,Binkley NCdoi
10.1007/s11657-019-0617-ysubject
Has Abstractpub_date
2019-06-28 00:00:00pages
72issue
1eissn
1862-3522issn
1862-3514pii
10.1007/s11657-019-0617-yjournal_volume
14pub_type
杂志文章abstract::We surveyed 573 physicians in the Middle East regarding osteoporosis management. Sixty percent had access to, but were not in charge of, densitometry reporting. Screening for secondary causes was common; 62% were aware of FRAX®; less than half used it. Medications were accessible, and most participants had concerns re...
journal_title:Archives of osteoporosis
pub_type: 杂志文章
doi:10.1007/s11657-019-0609-y
更新日期:2019-06-07 00:00:00
abstract::The article Estimated expenditures for hip fractures using merged healthcare insurance data for individuals aged ≥ 75 years and long-term care insurance claims data in Japan. ...
journal_title:Archives of osteoporosis
pub_type: 已发布勘误
doi:10.1007/s11657-019-0562-9
更新日期:2019-02-27 00:00:00
abstract::The effects of gluteal implants on bone mass remain unclear. Transgender women with ILS presented higher BMD in the hip compared with transgender women without implants, while no difference was observed in other sites. These results may be artifactual and suggest using spine/forearm sites for DXA in individuals with I...
journal_title:Archives of osteoporosis
pub_type: 杂志文章
doi:10.1007/s11657-020-00824-2
更新日期:2020-09-22 00:00:00
abstract::In November 2008, the "2nd Summit on Osteoporosis-Central and Eastern Europe (CEE)" was held in Warsaw, Poland. Discussions at this meeting focused on the identification and discussion of diagnostic, preventive, and therapeutic measures used in CEE. Evaluated information was used to identify issues regarding diagnosis...
journal_title:Archives of osteoporosis
pub_type: 杂志文章
doi:10.1007/s11657-009-0028-6
更新日期:2009-12-01 00:00:00
abstract::We investigated the effect of paravertebral muscle (PVM) on poor prognosis in osteoporotic vertebral fracture (OVF) and remaining lower back pain (LBP) in the thoracolumbar and lower lumbar regions. Additional OVF occurrence in the thoracolumbar and remaining LBP in the lumbar region was significantly related to PVM f...
journal_title:Archives of osteoporosis
pub_type: 杂志文章
doi:10.1007/s11657-020-00866-6
更新日期:2021-01-03 00:00:00
abstract::Hospital care and mortality of diabetic and non-diabetic osteoporotic Asian patients undergoing hip fracture surgery were explored with no difference in length of hospitalization, incidence of post-operative complications, or mortality between diabetics and non-diabetics seen. Time to operation correlated with post-op...
journal_title:Archives of osteoporosis
pub_type: 杂志文章
doi:10.1007/s11657-018-0440-x
更新日期:2018-03-15 00:00:00
abstract::The microstructure of autologous bone grafts from men over 50 years old and postmenopausal women undergoing spinal fusion were evaluated using micro-CT. We demonstrated postmenopausal women, especially those with osteoporosis (OP) presented more serious microarchitectural deterioration of bone grafts. PURPOSE:This st...
journal_title:Archives of osteoporosis
pub_type: 杂志文章
doi:10.1007/s11657-018-0422-z
更新日期:2018-03-05 00:00:00
abstract::We examined the effect of cumulative exposure to high doses of oral glucocorticoids on fracture risk. Compared to short-course users (daily dose ≥ 15 mg + cumulative < 1 g), heavy users (daily dose ≥ 15 mg + cumulative dose ≥ 1 g) had the highest risk of fracture. These patients should be monitored for fracture manage...
journal_title:Archives of osteoporosis
pub_type: 杂志文章
doi:10.1007/s11657-018-0424-x
更新日期:2018-03-18 00:00:00
abstract::Hip fracture becomes a major public health issue with the growing aging population. This study evaluated a multidisciplinary co-management program for older hip fracture patients and found it significantly improved the best practice indicators. It provided preliminary evidence to support the use of such intervention i...
journal_title:Archives of osteoporosis
pub_type: 杂志文章
doi:10.1007/s11657-019-0594-1
更新日期:2019-03-22 00:00:00
abstract::Older men who participated in a sporting activity were less likely to sustain any fracture or major osteoporotic fracture over a 6-year follow-up period. PURPOSE:Regular weight-bearing physical activity can reduce fracture risk through an increase in bone strength, as well as reducing falls risk by improving muscle s...
journal_title:Archives of osteoporosis
pub_type: 杂志文章
doi:10.1007/s11657-018-0459-z
更新日期:2018-04-19 00:00:00
abstract::Previous studies have shown that improving vitamin D status among the elderly may lead to an improvement in muscle mass and muscle strength. In our study, vitamin D supplementation showed significant improvements in vitamin D concentrations as well as appendicular muscle mass in pre-sarcopenic older Lebanese people. H...
journal_title:Archives of osteoporosis
pub_type: 杂志文章,随机对照试验
doi:10.1007/s11657-018-0553-2
更新日期:2018-12-19 00:00:00
abstract::In this prospective multicenter study of osteoporotic vertebral fractures (OVFs), delayed union of OVF at 6-month follow-up caused prolonged pain, QOL impairment, ADL impairment, cognitive status deterioration, and vertebral collapse progression. PURPOSE:Delayed union following osteoporotic vertebral fracture display...
journal_title:Archives of osteoporosis
pub_type: 杂志文章,多中心研究
doi:10.1007/s11657-017-0411-7
更新日期:2017-12-28 00:00:00
abstract::This study aims to determine the awareness of osteoporosis and factors that determine awareness of osteoporosis. Results showed that osteoporosis awareness was associated with age (p = 0.006) and occupation (p < 0.001) but not gender, marital status, and level of education. There is therefore need for educational inte...
journal_title:Archives of osteoporosis
pub_type: 杂志文章
doi:10.1007/s11657-017-0342-3
更新日期:2017-12-01 00:00:00
abstract::A systematic review and meta-analysis was conducted on the prevalence of osteoporosis in the Eastern Mediterranean Region. The overall pooled prevalence of osteoporosis was 24.4%. The prevalence has increased significantly over the recent years. The highest pooled prevalence was in Saudi Arabia (32.7%), and the lowest...
journal_title:Archives of osteoporosis
pub_type: 杂志文章,meta分析
doi:10.1007/s11657-018-0540-7
更新日期:2018-11-17 00:00:00
abstract::Trabecular bone score, an index of lumbar spine trabecular texture, has not been explored fully in adolescent girls. Our cross-sectional analysis supported the hypothesis that "adult normal" trabecular bone score has been achieved by the end of the first year post-menarche, providing a potential screening tool, indepe...
journal_title:Archives of osteoporosis
pub_type: 杂志文章
doi:10.1007/s11657-017-0388-2
更新日期:2017-10-18 00:00:00
abstract:UNLABELLED:Different sources were used to estimate the 2010 health care costs of managing low bone density (osteopenia/osteoporosis) plus caring fragility fractures in Mexico at 411 million USD. Figures are projected to rise 42 % by 2020. Preventive and timely interventions are required to decrease the financial burden...
journal_title:Archives of osteoporosis
pub_type: 杂志文章
doi:10.1007/s11657-013-0125-4
更新日期:2013-01-01 00:00:00
abstract::Hip fractures are common in elderly people. Despite great progress in surgical care, the outcomes of these patients remain disappointing. This study determined pre-fracture hospital admission as a prognostic variable for inferior functional outcomes and increased mortality rates in the perioperative phase and in the f...
journal_title:Archives of osteoporosis
pub_type: 杂志文章
doi:10.1007/s11657-017-0327-2
更新日期:2017-12-01 00:00:00
abstract::This study was undertaken to assess the effect of blood glucose on BMD and interactions with age, sex, and BMI in a Taiwanese population. Both obese and non-obese people with type 2 diabetes (T2DM) had higher BMD, at lumbar spine and femoral neck, compared with healthy subjects. In addition, the prevalence of osteopor...
journal_title:Archives of osteoporosis
pub_type: 杂志文章
doi:10.1007/s11657-018-0494-9
更新日期:2018-07-16 00:00:00
abstract:UNLABELLED:Bone mineral density (BMD), metabolic syndrome (MS), and vitamin D levels were evaluated in 73 indigenous from south of Brazil aged between 40 and 86 years. BMD loss in lumbar spine was detected in 63 %, MS was detected in 76.7 %, and vitamin D levels were altered in 67 % of subjects. PURPOSE:This study aim...
journal_title:Archives of osteoporosis
pub_type: 杂志文章
doi:10.1007/s11657-013-0134-3
更新日期:2013-01-01 00:00:00
abstract::In this study, we attempted to determine the epidemiology and clinical characteristics of hip fracture in the elderly. We find that elderly people with hip fracture have multiple comorbidities and suffer numerous complications. INTRODUCTION:We attempted to explore the epidemiology and clinical characteristics of hip ...
journal_title:Archives of osteoporosis
pub_type: 杂志文章
doi:10.1007/s11657-019-0580-7
更新日期:2019-03-12 00:00:00
abstract::This is a survey study concerning osteoporosis care during the COVID-19 pandemic in the Netherlands. Respondents reported that osteoporosis care stagnated and lower quality of care was provided. This leads to the conclusion that standardization of osteoporosis care delivery in situations of crisis is needed. PURPOSE:...
journal_title:Archives of osteoporosis
pub_type: 杂志文章
doi:10.1007/s11657-020-00856-8
更新日期:2021-01-07 00:00:00
abstract::Giant cell tumor (GCT) of the bone, also called osteoclastoma, is a rare complication of Paget's bone disease. We report a patient from Southern Italy who developed a GCT infiltrating the neighboring tissues. The natural history and the therapeutic outcomes of this unique complication of Paget's bone disease are prese...
journal_title:Archives of osteoporosis
pub_type: 杂志文章
doi:10.1007/s11657-009-0027-7
更新日期:2009-12-01 00:00:00
abstract:INTRODUCTION:Hyperparathyroidism often presents with asymptomatic hypercalcemia or minimal, unspecific symptoms and the middle-age female is the predominant population. CASE REPORT:We reported a young Vietnamese female with primary hyperparathyroidism presented with chronic low back pain of about 1 year duration, simi...
journal_title:Archives of osteoporosis
pub_type: 杂志文章
doi:10.1007/s11657-012-0072-5
更新日期:2012-01-01 00:00:00
abstract::If all adults with osteoporosis in the European Union (EU) and United States (US) used calcium and vitamin D supplements, it could prevent more than 500,000 fractures/year in the EU and more than 300,000/year in the US and save approximately €5.7 billion and US $3.3 billion annually. PURPOSE:Evaluate the cost-effecti...
journal_title:Archives of osteoporosis
pub_type: 杂志文章
doi:10.1007/s11657-019-0589-y
更新日期:2019-04-30 00:00:00
abstract::While adherence to osteoporosis treatment is low, patients' preference for osteoporosis treatment is unknown in Chinese patients. Chinese patients are willing to receive treatments with higher clinical efficacy and lower out-of-pocket cost. In addition, annual intravenous infusion and 6-month subcutaneous injection ar...
journal_title:Archives of osteoporosis
pub_type: 杂志文章
doi:10.1007/s11657-019-0624-z
更新日期:2019-07-31 00:00:00
abstract::The purpose of this study is to establish the prevalence and determinants of fractures among 974 Lebanese schoolchildren aged 8-18. Fractures might be less common in the Lebanese pediatric population compared to western populations. Male gender and high SES are independent risk factors for fractures, while 25(OH)D and...
journal_title:Archives of osteoporosis
pub_type: 杂志文章
doi:10.1007/s11657-019-0559-4
更新日期:2019-01-15 00:00:00
abstract::MrOS MsOS (Hong Kong) studies year 14 follow-up shows for subjects without baseline osteoporotic vertebral deformity, women's incident vertebral fracture (VF) rate was twice that of men. For subjects with vertebral deformity of baseline ≥ 20% height loss, counting subject, women's incident VF rate was three times high...
journal_title:Archives of osteoporosis
pub_type: 杂志文章
doi:10.1007/s11657-020-00845-x
更新日期:2020-11-07 00:00:00
abstract::A workflow tool for measurements of vertebral heights on lateral spine radiographs based on automated placements of 6 points per vertebra was evaluated. The tool helps to standardize point placement among operators. Its success rate is very good in normal vertebrae but lower in vertebrae with more severe fractures. Ma...
journal_title:Archives of osteoporosis
pub_type: 杂志文章
doi:10.1007/s11657-019-0577-2
更新日期:2019-02-11 00:00:00
abstract:UNLABELLED:Osteoporosis is common, and physical activity is important in its prevention and treatment. Of the categories of historical physical activity (PA) examined, we found that weight-bearing and very hard physical activity had the strongest relationships with areal bone mineral density (aBMD) throughout growth an...
journal_title:Archives of osteoporosis
pub_type: 杂志文章
doi:10.1007/s11657-015-0239-y
更新日期:2015-01-01 00:00:00
abstract::Osteocalcin, the osteoblast-derived protein, has been shown to be modulated in patients with problematic glucose metabolism. Our systematic review and meta-analysis found that in humans, higher blood osteocalcin level is associated with lower body indices of fat. PURPOSE/INTRODUCTION:Osteocalcin (OC) was found to be ...
journal_title:Archives of osteoporosis
pub_type: 杂志文章,meta分析
doi:10.1007/s11657-020-00812-6
更新日期:2020-09-18 00:00:00