Abstract:
:Ilimaquinone, a metabolite isolated from the marine sponge Hippiospongia metachromia, has antimicrobial, cytotoxic, anti-HIV, anti-inflammatory, and anti-cancer activities. A new quantitative analytical method for determination of ilimaquinone in rat plasma using HPLC-MS/MS was developed and validated. Ascorbic acid was added to ensure the stability of ilimaquinone in plasma. After protein precipitation using acetonitrile plus diclofenac as an internal standard, the analytes were chromatographed on a biphenyl column with a mobile phase of methanol and water (8:2, v/v, including 0.1% formic acid). This method was successfully applied in a pharmacokinetic study of ilimaquinone after oral administration in rats.
journal_name
J Pharm Biomed Analjournal_title
Journal of pharmaceutical and biomedical analysisauthors
Son H,Noh K,Kang C,Na M,Oh S,Song IS,Kang Wdoi
10.1016/j.jpba.2019.01.030subject
Has Abstractpub_date
2019-03-20 00:00:00pages
291-294eissn
0731-7085issn
1873-264Xpii
S0731-7085(18)32832-2journal_volume
166pub_type
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