Micro-computed tomography: a new diagnostic tool in postmortem assessment of brain anatomy in small fetuses.

Abstract:

PURPOSE:The aim of our study was to evaluate the postmortem micro-CT anatomy of early fetal human fetal brains, either in situ or isolated. METHODS:We studied 12 ex vivo specimens, 9 whole human fetuses (9-18 GW), and 3 isolated samples (16-26 GW). Specimens were fixed in formalin, then immersed in Lugol solution. Images were evaluated by two neuroradiologists. The depiction of CNS structures was defined based on the comparison between micro-CT images and a reference histologic anatomical Atlas of human brain development. RESULTS:Micro-CT provided informative high-resolution brain images in all cases, with the exception of one case (9 weeks) due to advanced maceration. All major CNS structures (i.e., brain hemispheres, layering, ventricles, germinal neuroepithelium, basal ganglia, corpus callosum, major cranial nerves, and structures of the head and neck) were recognizable. CONCLUSIONS:Micro-CT imaging of the early fetal brain is feasible and provides high-quality images that correlate with the histological Atlas of the human brain, offering multiplanar and volumetric images that can be stored and shared for clinical, teaching, and research purposes.

journal_name

Neuroradiology

journal_title

Neuroradiology

authors

Lombardi S,Scola E,Ippolito D,Zambelli V,Botta G,Cuttin S,Triulzi F,Lombardi CM

doi

10.1007/s00234-019-02168-2

subject

Has Abstract

pub_date

2019-07-01 00:00:00

pages

737-746

issue

7

eissn

0028-3940

issn

1432-1920

pii

10.1007/s00234-019-02168-2

journal_volume

61

pub_type

杂志文章
  • CT angiography and CT perfusion improve prediction of infarct volume in patients with anterior circulation stroke.

    abstract:INTRODUCTION:We investigated whether baseline CT angiography (CTA) and CT perfusion (CTP) in acute ischemic stroke could improve prediction of infarct presence and infarct volume on follow-up imaging. METHODS:We analyzed 906 patients with suspected anterior circulation stroke from the prospective multicenter Dutch acu...

    journal_title:Neuroradiology

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s00234-015-1636-z

    authors: van Seeters T,Biessels GJ,Kappelle LJ,van der Schaaf IC,Dankbaar JW,Horsch AD,Niesten JM,Luitse MJ,Majoie CB,Vos JA,Schonewille WJ,van Walderveen MA,Wermer MJ,Duijm LE,Keizer K,Bot JC,Visser MC,van der Lugt A,Dippel D

    更新日期:2016-04-01 00:00:00

  • A method for fast automated assessment of the magnetic resonance parkinsonism index.

    abstract::In patients with parkinsonian syndromes, and particularly during the early stages of the clinical disease, differentiating between idiopathic Parkinson's disease and progressive supranuclear palsy is challenging. Imaging plays an important role in early diagnosis, and the magnetic resonance parkinsonism index was show...

    journal_title:Neuroradiology

    pub_type: 杂志文章

    doi:10.1007/s00234-020-02380-5

    authors: Scheffler M,Maréchal B,Boto J,Lövblad KO,Vargas MI

    更新日期:2020-06-01 00:00:00

  • Spinal intradural extramedullary cavernous hemangioma.

    abstract::Spinal intradural extramedullary cavernous hemangiomas are very rare. Mixed intensities on T1- andT2-weighted images due to repeated hemorrhages and poor to absent contrast-enhancement are the most common imaging features of the disease allowing accurate differentiation from the far more frequent meningiomas and schwa...

    journal_title:Neuroradiology

    pub_type: 杂志文章

    doi:10.1007/s00234-018-2073-6

    authors: Pétillon P,Wilms G,Raftopoulos C,Duprez T

    更新日期:2018-10-01 00:00:00

  • CT angiography covering both cervical and cerebral arteries using high iodine concentration contrast material with dose reduction on a 16 multidetector-row system.

    abstract:INTRODUCTION:Our aim was to examine the feasibility of a computed tomographic angiography (CTA) protocol using a reduced dose of high-concentration contrast material on a 16 multidetector-row system to visualize both cervical and cerebral arteries in one session. METHODS:In 31 consecutive patients, we performed CTA co...

    journal_title:Neuroradiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00234-009-0611-y

    authors: Fujikawa A,Tsuchiya K,Imai M,Nitatori T

    更新日期:2010-04-01 00:00:00

  • Diffusion and perfusion MRI for the localisation of epileptogenic foci in drug-resistant epilepsy.

    abstract::Drug-resistant epilepsy is an important clinical challenge, both diagnostically and therapeutically. More and more surgical options are being considered, but precise presurgical assessment is necessary. We prospectively studied eight patients with drug-resistant epilepsy, who underwent clinical examination, single pho...

    journal_title:Neuroradiology

    pub_type: 杂志文章

    doi:10.1007/s00234-002-0785-z

    authors: Heiniger P,el-Koussy M,Schindler K,Lövblad KO,Kiefer C,Oswald H,Wissmeyer M,Mariani L,Donati F,Schroth G,Weder B

    更新日期:2002-06-01 00:00:00

  • Computerized tomography and encephalography.

    abstract::This preliminary paper compares encephalography and computed tomography as regards the duration of the examinations, the technical difficulties and their diagnostic values. Some examples are reported to demonstrate the complementary importance of the two techniques. ...

    journal_title:Neuroradiology

    pub_type: 杂志文章

    doi:10.1007/BF00335034

    authors: Ruggiero G,Sabattini L,Nuzzo G

    更新日期:1977-03-28 00:00:00

  • Extraspinal abnormalities identified on lumbar spine CT.

    abstract::Retrospective review of 1517 lumbar CT examinations revealed extraspinal pathology in 22 (1.45%). Retroperitoneal tumors and lymphadenopathy as well as vascular, urinary tract and gynecologic abnormalities were identified. This study demonstrates the need to carefully evaluate the visualized portions of the abdomen an...

    journal_title:Neuroradiology

    pub_type: 杂志文章

    doi:10.1007/BF00341767

    authors: Frager DH,Elkin CM,Kansler F,Mendelsohn SL,Leeds NE

    更新日期:1986-01-01 00:00:00

  • CT scanning for the diagnosis of the cerebrellar and spinal lesions of von Hippel-Lindau's disease.

    abstract::The CT features of cerebellar lesions with von Hippel-Lindau's disease are analyzed. The use of CT scanning for associated spinal hemangioblastomas is discussed in the light of a case with a low cervical lesion. The role of computed tomography in the neuroradiological investigations is discussed. ...

    journal_title:Neuroradiology

    pub_type: 杂志文章

    doi:10.1007/BF00418622

    authors: Balériaux-Waha D,Retif J,Noterman J,Terwinghe G,Mortelmans LL,Dupont MG,Jeanmart L

    更新日期:1978-02-17 00:00:00

  • High-resolution blood-pool-contrast-enhanced MR angiography in glioblastoma: tumor-associated neovascularization as a biomarker for patient survival. A preliminary study.

    abstract:INTRODUCTION:The objective of the study was to determine whether tumor-associated neovascularization on high-resolution gadofosveset-enhanced magnetic resonance angiography (MRA) is a useful biomarker for predicting survival in patients with newly diagnosed glioblastomas. METHODS:Before treatment, 35 patients (25 men;...

    journal_title:Neuroradiology

    pub_type: 杂志文章

    doi:10.1007/s00234-015-1599-0

    authors: Puig J,Blasco G,Daunis-I-Estadella J,Alberich-Bayarri A,Essig M,Jain R,Remollo S,Hernández D,Puigdemont M,Sánchez-González J,Mateu G,Wintermark M,Pedraza S

    更新日期:2016-01-01 00:00:00

  • Double microcatheter technique for endovascular coiling of wide-neck aneurysms using a new guiding device for the transcarotid approach: technical note.

    abstract::In the endovascular treatment of cerebrovascular diseases, positioning the guiding catheter is of great importance. In cases where vessel tortuosity prohibits positioning the guiding catheter in the carotid artery via the femoral approach, we use a direct carotid approach via common carotid artery puncture. For direct...

    journal_title:Neuroradiology

    pub_type: 杂志文章

    doi:10.1007/s00234-004-1277-0

    authors: Kai Y,Hamada J,Morioka M,Yano S,Mizuno T,Kuratsu J

    更新日期:2005-01-01 00:00:00

  • Relationships between portions of the third and fourth ventricles. An aid to stereotactic accuracy for posterior fossa stereotaxy.

    abstract::The relationships between the third and fourth ventricles have been studied by examination of the angles formed by third and fourth ventricular projections. These have been subjected to statistical analysis and have proved useful for posterior fossa stereotactic surgery. ...

    journal_title:Neuroradiology

    pub_type: 杂志文章

    doi:10.1007/BF00327527

    authors: Hitchcock E,Oppitz P,Donaldson AA

    更新日期:1978-08-18 00:00:00

  • Anomalous origin of the posterior meningeal artery from the lateral medullary segment of the posterior inferior cerebellar artery.

    abstract::The authors present two cases of angiographically-confirmed anomalous origin of the posterior meningeal artery (PMA) from the lateral segment of the posterior inferior cerebellar artery (PICA) and describe briefly the probable embryogenesis of this anomaly. ...

    journal_title:Neuroradiology

    pub_type: 杂志文章

    doi:10.1007/BF00341048

    authors: Tanohata K,Maehara T,Noda M,Katoh H,Sugiyama S,Okazaki A

    更新日期:1987-01-01 00:00:00

  • Sigmoid and transverse sinus thrombosis after closed head injury presenting with unilateral hearing loss.

    abstract::Sinus thrombosis has rarely been associated with closed head injury; more often, thrombosis of the sigmoid or transverse sinus is caused by otogenic inflammations or tumours, or occurs during pregnancy. Symptoms are frequently vague, while untreated thrombus progression may be fatal due to venous congestion and infarc...

    journal_title:Neuroradiology

    pub_type: 杂志文章

    doi:10.1007/pl00006045

    authors: Brors D,Schäfers M,Schick B,Dazert S,Draf W,Kahle G

    更新日期:2001-02-01 00:00:00

  • The place of digital intravenous angiography in cerebral infarcts.

    abstract::The authors describe their technique of intravenous digital subtraction angiography (IVDSA) and discuss the results in cerebral infarcts. IVDSA is a good first stage examination for the recognition of stenosis or occlusion of cervical vessels to the brain, as it is an only marginally invasive and easy technique. It is...

    journal_title:Neuroradiology

    pub_type: 杂志文章

    doi:10.1007/BF00340849

    authors: Thiebot J,Clavier E

    更新日期:1985-01-01 00:00:00

  • Alcohol percutaneous neurolysis of the sphenopalatine ganglion in the management of refractory cranio-facial pain.

    abstract:INTRODUCTION:The sphenopalatine ganglion (SPN) has been proven to be involved in various types of facial pain syndromes. Management of these cranio-facial pain syndromes can be challenging, and existing specific treatments are sometimes inefficient and may fail. The purpose of this study is to describe and evaluate alc...

    journal_title:Neuroradiology

    pub_type: 杂志文章

    doi:10.1007/s00234-014-1354-y

    authors: Kastler A,Cadel G,Comte A,Gory G,Piccand V,Tavernier L,Kastler B

    更新日期:2014-07-01 00:00:00

  • Visualization of flow diverter stent wall apposition during intracranial aneurysm treatment using a virtually diluted cone beam CT technique (Vessel ASSIST).

    abstract:PURPOSE:Flow diverters (FD) have poor radiopacity, challenging visualization of deployment and vessel wall apposition with conventional neuroimaging modalities. We evaluated a novel cone beam computed tomography (CT) imaging technique that allows virtual dilution (VD) of contrast media to facilitate workflow and ensure...

    journal_title:Neuroradiology

    pub_type: 杂志文章

    doi:10.1007/s00234-020-02507-8

    authors: Hassan AE,Wise J,Burke EM,Tekle WG

    更新日期:2021-01-01 00:00:00

  • The excessively small ventricle on computed axial tomography of the brain.

    abstract::Computed axial tomography has made it possible to observe excessively small ventricles in a variety of disorders of the CNS. This finding is presumably due to non-specific and diffuse swelling of brain parenchyma, and is illustrated in cases of trauma, neoplasm, encephalitis, pseudotumor cerebri, metabolic disorder, a...

    journal_title:Neuroradiology

    pub_type: 杂志文章

    doi:10.1007/BF00341858

    authors: Hahn FJ,Schapiro RL

    更新日期:1976-01-01 00:00:00

  • MRI demonstration of cervical meningocele.

    abstract::The MRI appearances of a cervical meningocele are reported. The operation demonstrated the accuracy of the preoperative MRI diagnosis. ...

    journal_title:Neuroradiology

    pub_type: 杂志文章

    doi:10.1007/BF00588722

    authors: Ando S,Moritake K,Takaya M

    更新日期:1993-01-01 00:00:00

  • Image-guided microneurosurgical management of small cerebral arteriovenous malformations: the value of navigated computed tomographic angiography.

    abstract::In small arteriovenous malformations (AVM) with large hematomas, surgery remains the main therapeutic option. However, intraoperative identification of the AVM, feeders, and draining veins could be difficult in the environment of substantial intracerebral blood. In those selected cases, we use navigated computed tomog...

    journal_title:Neuroradiology

    pub_type: 杂志文章

    doi:10.1007/s00234-004-1307-y

    authors: Coenen VA,Dammert S,Reinges MH,Mull M,Gilsbach JM,Rohde V

    更新日期:2005-01-01 00:00:00

  • Endovascular transplantation of stem cells to the injured rat CNS.

    abstract:INTRODUCTION:Transplantation procedures using intraparenchymal injection of stem cells result in tissue injury in addition to associated surgical risks. Intravenous injection of mesenchymal stem cells gives engraftment to lesions, but the method has low efficiency and specificity. In traumatic brain injuries (TBI), the...

    journal_title:Neuroradiology

    pub_type: 杂志文章

    doi:10.1007/s00234-009-0551-6

    authors: Lundberg J,Le Blanc K,Söderman M,Andersson T,Holmin S

    更新日期:2009-10-01 00:00:00

  • Doppler color flow imaging of common carotid artery dissection.

    abstract::Sonographic findings are reported in a case of common carotid artery dissection assessed by Doppler color flow imaging and confirmed by angiography. Advantages and clinical relevance of this new ultrasound method for this diagnosis are discussed. ...

    journal_title:Neuroradiology

    pub_type: 杂志文章

    doi:10.1007/BF02426464

    authors: Steinke W,Schwartz A,Hennerici M

    更新日期:1990-01-01 00:00:00

  • Morphological dissociation between visual pathways and cortex: MRI of visually-deprived patients with congenital peripheral blindness.

    abstract::MRI was used to study possible morphological changes in the visual system in 12 patients suffering from congenital blindness of peripheral (ocular) origin. While their optical pathways showed degeneration, hypoplasia or atrophy in 7 out of 12 cases, the occipital cortex appeared normal in all cases. This dissociation ...

    journal_title:Neuroradiology

    pub_type: 杂志文章

    doi:10.1007/s002340050616

    authors: Breitenseher M,Uhl F,Prayer Wimberger D,Deecke L,Trattnig S,Kramer J

    更新日期:1998-07-01 00:00:00

  • Failure of stent-assisted endovascular treatment for ruptured dissecting aneurysms of the basilar artery.

    abstract::We report two instructive cases of ruptured dissecting aneurysm of the basilar artery. Although stent-assisted endovascular treatment was successful, recurrent bleeding occurred 4 h after the procedure in one patient, and the other's basilar artery occluded 6 days after the procedure. These cases suggest that the high...

    journal_title:Neuroradiology

    pub_type: 杂志文章

    doi:10.1007/s00234-002-0903-y

    authors: Kaku Y,Yoshimura S,Yamakawa H,Sakai N

    更新日期:2003-01-01 00:00:00

  • Accelerated territorial arterial spin labeling based on shared rotating control acquisition: an observer study for validation.

    abstract:INTRODUCTION:Shared rotating control acquisition can shorten the imaging time of territorial arterial spin labeling (tASL) by 33% compared with the normal control acquisition scheme but potentially results in an inaccurate estimate of vascular territories due to imperfect magnetization transfer compensation. Our purpos...

    journal_title:Neuroradiology

    pub_type: 杂志文章

    doi:10.1007/s00234-011-0919-2

    authors: Kamano H,Yoshiura T,Hiwatashi A,Yamashita K,Takayama Y,Nagao E,Sagiyama K,Zimine I,Honda H

    更新日期:2012-01-01 00:00:00

  • Incidence of abnormal retropharyngeal lymph nodes in sinonasal malignancies among adults.

    abstract:INTRODUCTION:The aim of this study is to investigate the relationship between abnormal retropharyngeal lymph nodes (RPLNs) and sinonasal malignancies among adults. METHODS:Magnetic resonance and computed tomography images from 89 patients over 20 years old who were all histopathologically confirmed to have sinonasal m...

    journal_title:Neuroradiology

    pub_type: 杂志文章

    doi:10.1007/s00234-014-1428-x

    authors: Sai A,Shimono T,Yamamoto A,Takeshita T,Ohsawa M,Wakasa K,Miki Y

    更新日期:2014-12-01 00:00:00

  • Dementia imaging in clinical practice: a European-wide survey of 193 centres and conclusions by the ESNR working group.

    abstract:PURPOSE:Through a European-wide survey, we assessed the current clinical practice of imaging in the primary evaluation of dementia, with respect to standardised imaging, evaluation and reporting. METHODS:An online questionnaire was emailed to all European Society of Neuroradiology (ESNR) members (n = 1662) and non-mem...

    journal_title:Neuroradiology

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s00234-019-02188-y

    authors: Vernooij MW,Pizzini FB,Schmidt R,Smits M,Yousry TA,Bargallo N,Frisoni GB,Haller S,Barkhof F

    更新日期:2019-06-01 00:00:00

  • Contrast-enhanced FLAIR in the early diagnosis of infectious meningitis.

    abstract::We investigated the accuracy of MRI in the early diagnosis of infectious meningitis with emphasis on the value of gadolinium-enhanced fluid-attenuated inversion recovery (FLAIR) sequence. Twenty-seven patients with clinical suspicion of infectious meningitis were included. MRI was performed within 3 h of clinical eval...

    journal_title:Neuroradiology

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00234-005-1383-7

    authors: Splendiani A,Puglielli E,De Amicis R,Necozione S,Masciocchi C,Gallucci M

    更新日期:2005-08-01 00:00:00

  • Imaging of the normal pontine cisternal segment of the abducens nerve, using three-dimensional constructive interference in the steady state MRI.

    abstract::Our objective was to determine the visibility of the cisternal segment of the normal abducens nerve using a three-dimensional Fourier-Transform constructive interference in the steady state (3DFT-CISS) sequence. Its visibility was rated in 150 patients without clinical evidence of abducens nerve disturbance. Axial 1-m...

    journal_title:Neuroradiology

    pub_type: 杂志文章

    doi:10.1007/s002340050770

    authors: Lemmerling M,De Praeter G,Mortelé K,Vyt S,Vanzieleghem B,Coolens D,Kunnen M

    更新日期:1999-05-01 00:00:00

  • Reconstructive treatment of dural arteriovenous fistulas of the transverse and sigmoid sinus: transvenous angioplasty and stent deployment.

    abstract::Various techniques for the endovascular treatment of dural arteriovenous fistulas (dAVFs) of the transverse and sigmoid sinus have recently evolved. Transvenous coil occlusion of the involved segment and transarterial embolization of the feeding arteries with liquid agents are the commonest treatments utilized. Howeve...

    journal_title:Neuroradiology

    pub_type: 杂志文章

    doi:10.1007/s00234-005-1377-5

    authors: Liebig T,Henkes H,Brew S,Miloslavski E,Kirsch M,Kühne D

    更新日期:2005-07-01 00:00:00

  • Comparison of the precision of two standardized co-ordinate systems for the quantitation of brain anatomy: preliminary results.

    abstract::We assessed reproducible definition of two standardized co-ordinate systems for intersubject analysis of brain images. The baselines in the two co-ordinate systems were a modification of the canthomeatal (mCM) line and the anterior-posterior commissural (AC-PC) line. Axial spin-echo MR images of four subjects at 1.5T ...

    journal_title:Neuroradiology

    pub_type: 杂志文章

    doi:10.1007/BF00593507

    authors: Sandor T,Tieman J,Ong HT,Moss MB,Jolesz F,Albert M

    更新日期:1994-10-01 00:00:00