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Coronary patency after intravenous infusion of recombinant tissue-type plasminogen activator in acute myocardial infarction.

Abstract：

:The relation between coronary patency after infusion of recombinant tissue-type plasminogen activator (rt-PA) and clinical and laboratory findings was assessed in patients with acute myocardial infarction. This study focused primarily on information available early in the hospitalization phase. Data were available for 243 patients who received the full dose of rt-PA and who had assessable coronary angiograms 90 min after the start of the intravenous infusion. The infarct-related vessel was scored by an independent assessment committee as being patent in 65% of patients. The left anterior descending coronary artery was involved in 53% of patients, and proximal localization of the infarct-related vessel occurred in 65%. In the majority of patients (85%), the infusion was started within 4 h of the acute event. Neither the angiographic location of the infarct-related vessel nor electrocardiographic evidence of infarct severity or location appeared to have a bearing on thrombolysis with rt-PA. Multivariate logistic regression analysis identified three independent predictors of coronary patency: hematocrit 43 to 47%, blood plasminogen level greater than or equal to 90% of normal and serum alkaline phosphatase greater than or equal to 82% of the local upper normal limit. In addition, the use of intravenous nitrates suggests a positive association with patency.

journal_name

J Am Coll Cardiol

journal_title

Journal of the American College of Cardiology

authors

Brower RW,Arnold AE,Lubsen J,Verstraete M

doi

10.1016/0735-1097(88)90196-9

subject

Has Abstract

pub_date

1988-04-01 00:00:00

pages

681-8

issue

4

eissn

0735-1097

issn

1558-3597

pii

0735-1097(88)90196-9

journal_volume

11

pub_type

杂志文章

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