Abstract：
:One snapshot of the peer review process for "Death Rate of E. coli during Starvation Is Set by Maintenance Cost and Biomass Recycling" (Schink et al., 2019).
journal_name
Cell Systjournal_title
Cell systemsauthors
Laman Trip DS,Maire T,Youk Hdoi
10.1016/j.cels.2019.07.004subject
Has Abstractpub_date
2019-07-24 00:00:00pages
3-7issue
1eissn
2405-4712issn
2405-4720pii
S2405-4712(19)30235-2journal_volume
9pub_type
评论,杂志文章相关文献
Cell Systems文献大全abstract：:It is unclear how standing genetic variation affects the prognosis of prostate cancer patients. To provide one controlled answer to this problem, we crossed a dominant, penetrant mouse model of prostate cancer to Diversity Outbred mice, a collection of animals that carries over 40 million SNPs. Integration of disease ...
journal_title：Cell systems
pub_type： 杂志文章
doi：10.1016/j.cels.2016.10.018
更新日期：2017-01-25 00:00:00
abstract：:Living systems integrate biochemical reactions that determine the functional state of each cell. Reactions are primarily mediated by proteins. In proteomic studies, these have been treated as independent entities, disregarding their higher-level organization into complexes that affects their activity and/or function a...
journal_title：Cell systems
pub_type： 杂志文章
doi：10.1016/j.cels.2020.01.001
更新日期：2020-02-26 00:00:00
abstract：:Understanding the complex interactions that occur between heterologous and native biochemical pathways represents a major challenge in metabolic engineering and synthetic biology. We present a workflow that integrates metabolomics, proteomics, and genome-scale models of Escherichia coli metabolism to study the effects...
journal_title：Cell systems
pub_type： 杂志文章
doi：10.1016/j.cels.2016.04.004
更新日期：2016-05-25 00:00:00
abstract：:Effective design of combination therapies requires understanding the changes in cell physiology that result from drug interactions. Here, we show that the genome-wide transcriptional response to combinations of two drugs, measured at a rigorously controlled growth rate, can predict higher-order antagonism with a third...
journal_title：Cell systems
pub_type： 杂志文章
doi：10.1016/j.cels.2019.10.004
更新日期：2019-11-27 00:00:00
abstract：:Two studies show that noise is a key ingredient of new mechanisms for entraining the NF-κB system. ...
journal_title：Cell systems
pub_type： 杂志文章
doi：10.1016/j.cels.2016.12.008
更新日期：2016-12-21 00:00:00
abstract：:The construction of complex gene-regulatory networks requires both inhibitory and upregulatory modules. However, the vast majority of RNA-based regulatory "parts" are inhibitory. Using a synthetic biology approach combined with SHAPE-seq, we explored the regulatory effect of RNA-binding protein (RBP)-RNA interactions ...
journal_title：Cell systems
pub_type： 杂志文章
doi：10.1016/j.cels.2019.04.007
更新日期：2019-07-24 00:00:00
abstract：:We combine a genome-scale RNAi screen in mouse epiblast stem cells (EpiSCs) with genetic interaction, protein localization, and "protein-level dependency" studies-a systematic technique that uncovers post-transcriptional regulation-to delineate the network of factors that control the expression of Oct4, a key regulato...
journal_title：Cell systems
pub_type： 杂志文章
doi：10.1016/j.cels.2015.08.002
更新日期：2015-08-26 00:00:00
abstract：:Isogenic cells in a common environment show substantial cell-to-cell variation in gene expression, often referred to as "expression noise." Here, we use multiple single-cell RNA-sequencing datasets to identify features associated with high or low expression noise in mouse embryonic stem cells. These include the core p...
journal_title：Cell systems
pub_type： 杂志文章
doi：10.1016/j.cels.2017.10.003
更新日期：2017-11-22 00:00:00
abstract：:Patterning of periodic stripes during development requires mechanisms to control both stripe spacing and orientation. A number of models can explain how stripe spacing is controlled, including molecular mechanisms, such as Turing's reaction-diffusion model, as well as cell-based and mechanical mechanisms. However, how...
journal_title：Cell systems
pub_type： 杂志文章
doi：10.1016/j.cels.2015.12.001
更新日期：2015-12-23 00:00:00
abstract：:Recent advances in synthetic biology and biological system engineering have allowed the design and construction of engineered live biotherapeutics targeting a range of human clinical applications. In this review, we outline how systems approaches have been used to move from simple constitutive systems, where a single ...
journal_title：Cell systems
pub_type： 杂志文章,评审
doi：10.1016/j.cels.2018.06.008
更新日期：2018-07-25 00:00:00
abstract：:The human interactome is instrumental in the systems-level study of the cell and the contextualization of disease-associated gene perturbations. However, reference organismal interactomes do not capture the cell-type-specific context in which proteins and modules preferentially act. Here, we introduce SCINET, a comput...
journal_title：Cell systems
pub_type： 杂志文章
doi：10.1016/j.cels.2019.10.007
更新日期：2019-12-18 00:00:00
abstract：:Many data sets exhibit well-defined structure that can be exploited to design faster search tools, but it is not always clear when such acceleration is possible. Here we introduce a framework for similarity search based on characterizing a data set's entropy and fractal dimension. We prove that searching scales in tim...
journal_title：Cell systems
pub_type： 杂志文章
doi：10.1016/j.cels.2015.08.004
更新日期：2015-08-26 00:00:00
abstract：:Gram-negative bacteria are intrinsically resistant to drugs because of their double-membrane envelope structure that acts as a permeability barrier and as an anchor for efflux pumps. Antibiotics are blocked and expelled from cells and cannot reach high-enough intracellular concentrations to exert a therapeutic effect....
journal_title：Cell systems
pub_type： 杂志文章
doi：10.1016/j.cels.2019.03.008
更新日期：2019-04-24 00:00:00
abstract：:Overlap of RNA and protein networks reveals glia cells as key players for the development of symptomatic Alzheimer's disease in humans. ...
journal_title：Cell systems
pub_type： 评论,杂志文章
doi：10.1016/j.cels.2017.02.006
更新日期：2017-02-22 00:00:00
abstract：:This month: imaging the organelle interactome (Lippincott-Schwartz), big data immunology (Pulendran, Ginhoux), protein interactomes expand (Barna, Harper, Marcotte), and computation/engineering insights (Milinkovitch, Silver, and Sastry). ...
journal_title：Cell systems
pub_type： 杂志文章
doi：10.1016/j.cels.2017.06.010
更新日期：2017-06-28 00:00:00
abstract：:Clinically used RAF inhibitors are ineffective in RAS mutant tumors because they enhance homo- and heterodimerization of RAF kinases, leading to paradoxical activation of ERK signaling. Overcoming enhanced RAF dimerization and the resulting resistance is a challenge for drug design. Combining multiple inhibitors could...
journal_title：Cell systems
pub_type： 杂志文章
doi：10.1016/j.cels.2018.06.002
更新日期：2018-08-22 00:00:00
abstract：:Cell-to-cell variation in gene expression and the propagation of such variation (PoV or "noise propagation") from one gene to another in the gene network, as reflected by gene-gene correlation across single cells, are commonly observed in single-cell transcriptomic studies and can shape the phenotypic diversity of cel...
journal_title：Cell systems
pub_type： 杂志文章
doi：10.1016/j.cels.2017.03.002
更新日期：2017-04-26 00:00:00
abstract：:Racism and COVID-19 represent a pandemic on a pandemic for Blacks. The pandemics find themselves synergized to the detriment of Blacks and their health. The complexity of the combination of these pandemics are evident when examining the interplay between racist policing practices and health. ...
journal_title：Cell systems
pub_type： 杂志文章
doi：10.1016/j.cels.2020.07.002
更新日期：2020-07-22 00:00:00
abstract：:Studying autism genes in the context of the protein complexes to which they belong illustrates the potential of network-centric approaches for understanding complex genetic disease. ...
journal_title：Cell systems
pub_type： 杂志文章
doi：10.1016/j.cels.2015.11.004
更新日期：2015-11-25 00:00:00
abstract：:Small RNA sequencing has been widely adopted to study the diversity of extracellular RNAs (exRNAs) in biofluids; however, the analysis of exRNA samples can be challenging: they are vulnerable to contamination and artifacts from different isolation techniques, present in lower concentrations than cellular RNA, and occa...
journal_title：Cell systems
pub_type： 杂志文章
doi：10.1016/j.cels.2019.03.004
更新日期：2019-04-24 00:00:00
abstract：:The tumor-suppressing transcription factor p53 is highly conserved at the protein level and plays a key role in the DNA damage response. One important aspect of p53 regulation is its dynamics in response to DNA damage, which include oscillations. Here, we observe that, while the qualitative oscillatory nature of p53 d...
journal_title：Cell systems
pub_type： 杂志文章
doi：10.1016/j.cels.2017.09.012
更新日期：2017-10-25 00:00:00
abstract：:Cell classifiers are genetic logic circuits that transduce endogenous molecular inputs into cell-type-specific responses. Designing classifiers that achieve optimal differential response between specific cell types is a hard computational problem because it involves selection of endogenous inputs and optimization of b...
journal_title：Cell systems
pub_type： 杂志文章
doi：10.1016/j.cels.2017.01.003
更新日期：2017-02-22 00:00:00
abstract：:Adenocarcinoma accounts for more than 40% of lung malignancy, and microscopic pathology evaluation is indispensable for its diagnosis. However, how histopathology findings relate to molecular abnormalities remains largely unknown. Here, we obtained H&E-stained whole-slide histopathology images, pathology reports, RNA ...
journal_title：Cell systems
pub_type： 杂志文章
doi：10.1016/j.cels.2017.10.014
更新日期：2017-12-27 00:00:00
abstract：:All mammals progress through similar physiological stages throughout life, from early development to puberty, aging, and death. Yet, the extent to which this conserved physiology reflects underlying genomic events is unclear. Here, we map the common methylation changes experienced by mammalian genomes as they age, foc...
journal_title：Cell systems
pub_type： 杂志文章
doi：10.1016/j.cels.2020.06.006
更新日期：2020-08-26 00:00:00
abstract：:Single-cell RNA-seq has emerged as a powerful tool in diverse applications, from determining the cell-type composition of tissues to uncovering regulators of developmental programs. A near-universal step in the analysis of single-cell RNA-seq data is to hypothesize the identity of each cell. Often, this is achieved by...
journal_title：Cell systems
pub_type： 杂志文章
doi：10.1016/j.cels.2019.06.004
更新日期：2019-08-28 00:00:00
abstract：:Advances in biological engineering headline this month's Cell Systems call (Cell Systems 1, 307), alongside intriguing applications of modeling from the Elf, Goentoro, and Wolf groups. Check out our recent blogpost: http://crosstalk.cell.com/blog/a-call-for-papers-on-biological-engineering-and-synthetic-biology. ...
journal_title：Cell systems
pub_type： 杂志文章
doi：10.1016/j.cels.2016.08.006
更新日期：2016-08-01 00:00:00
abstract：:Systematic assessment of tyrosine kinase-substrate relationships is fundamental to a better understanding of cellular signaling and its profound alterations in human diseases such as cancer. In human cells, such assessments are confounded by complex signaling networks, feedback loops, conditional activity, and intra-k...
journal_title：Cell systems
pub_type： 杂志文章
doi：10.1016/j.cels.2017.08.001
更新日期：2017-08-23 00:00:00
abstract：:Ribosome profiling is a widespread tool for studying translational dynamics in human cells. Its central assumption is that ribosome footprint density on a transcript quantitatively reflects protein synthesis. Here, we test this assumption using pulsed-SILAC (pSILAC) high-accuracy targeted proteomics. We focus on multi...
journal_title：Cell systems
pub_type： 杂志文章
doi：10.1016/j.cels.2017.05.001
更新日期：2017-06-28 00:00:00
abstract：:Longitudinal DNA sequencing of cancer patients yields insight into how tumors evolve over time or in response to treatment. However, sequencing data from bulk tumor samples often have considerable ambiguity in clonal composition, complicating the inference of ancestral relationships between clones. We introduce Cancer...
journal_title：Cell systems
pub_type： 杂志文章
doi：10.1016/j.cels.2019.05.010
更新日期：2019-06-26 00:00:00
abstract：:Proper segregation of the replicated genome requires that kinetochores form and maintain bioriented, amphitelic attachments to microtubules from opposite spindle poles and eliminate erroneous, syntelic attachments to microtubules from the same spindle pole. Phosphorylation of kinetochore proteins destabilizes low-tens...
journal_title：Cell systems
pub_type： 杂志文章
doi：10.1016/j.cels.2017.05.003
更新日期：2017-06-28 00:00:00
