当前位置： SCI文献检索 > Pakistan Journal of Medical Sciences期刊下所有文献 > Evaluation of kidney injury molecule-1 as a disease progression biomarker in diabetic nephropathy.

Evaluation of kidney injury molecule-1 as a disease progression biomarker in diabetic nephropathy.

Abstract：

Background & Objective:Kidney Injury Molecule-1 (KIM-1) is a peptide whose release into circulation is specific to tubular injury. This study aimed to estimate levels of kidney injury molecule-1 in diabetic patients with and without kidney disease. And evaluate the role of KIM-1 as an early screening marker of progressive kidney injury. Methods:This follow-up study included n=85 subjects from the diabetic clinic of Jinnah Post Graduate Medical Center (JPMC) in collaboration with Aga Khan University from November 2016 till September 2017. They were divided as: i) Group A1 (n=30) participants with diabetes for <5 years without microalbuminuria ii) Group A2 (n= 30) subjects with diabetes for 6-10 years with microalbuminuria; iii) Group B (n=25) subjects as healthy control group. All study participants were followed for 6 months and their blood glucose, urea, creatinine, electrolytes, albuminuria and serum KIM-1 were assayed. Results:High KIM-1 at baseline was present in group A2 patients as compared to controls and group A1 (p<0.001). Higher levels were seen after six months in group A1 along with the presence of micro albuminuria (p<0.001) suggesting kidney damage. Moderate positive association were seen for KIM1 with creatinine levels (r=0.530; p<0.001), and HbA1c (r=0.576; p<0.001) in all patients. While a strong positive association was seen for blood urea nitrogen as a marker for kidney function both at baseline (r= 0.728; p=0.000) and follow up (r=0.747; p=0.001). Multiple logistic regression controlling for age showed that KIM1 was independently associated with BUN (r=0.727; p<0.001), creatinine (r=0.510; p<0.001) and HbA1c (r=0.401; p=0.008) in all groups. Conclusion:Rising KIM-1 levels with progressive kidney damage with or without derangement of kidney function is reported in this study. This finding may pave a way towards identifying KIM1 as a prognostic marker for kidney injury.

journal_name

Pak J Med Sci

journal_title

Pakistan journal of medical sciences

authors

Khan FA,Fatima SS,Khan GM,Shahid S

doi

10.12669/pjms.35.4.154

subject

Has Abstract

pub_date

2019-07-01 00:00:00

pages

992-996

issue

eissn

1682-024X

issn

1681-715X

pii

PJMS-35-992

journal_volume

pub_type

杂志文章

在线工具

Evaluation of kidney injury molecule-1 as a disease progression biomarker in diabetic nephropathy.