Pediatric Monogenic Diabetes: A Unique Challenge and Opportunity.

Abstract:

:Monogenic diabetes affects approximately 120,000 people in the United States but continues to be misdiagnosed. Within the pediatric population, 1% to 3% of diabetes is monogenic, and early diagnosis and genetically targeted management of congenital diabetes and maturity onset diabetes of the young (MODY) can have a tremendous impact on future health outcomes and quality of life. In some of the more common monogenic diabetes types, patients can switch from insulin therapy to sulfonylureas or even discontinue glucose-lowering therapy with stable glycemic control. Advancements in the field have identified tools and resources to aid in distinguishing patients likely to have monogenic diabetes from the more common forms of type 1 and type 2 diabetes. However, genetic testing with accurate interpretation of results is necessary to confirm a diagnosis and direct treatment selection and disease management. This article discusses challenges and opportunities in monogenic diabetes in the pediatric population. [Pediatr Ann. 2019;48(8):e319-e325.].

journal_name

Pediatr Ann

journal_title

Pediatric annals

authors

Harris A,Naylor RN

doi

10.3928/19382359-20190730-02

subject

Has Abstract

pub_date

2019-08-01 00:00:00

pages

e319-e325

issue

8

eissn

0090-4481

issn

1938-2359

journal_volume

48

pub_type

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