Pulsed Electrical Stimulation of the Human Eye Enhances Retinal Vessel Reaction to Flickering Light.

Abstract:

:Recent studies indicate therapeutic benefits of electrical stimulation in cases of specific ophthalmic diseases that are associated with dysfunctional ocular microcirculation. This suggests effects of electrical stimulation on vascular functions. In the present study, we investigated the effects of electrical stimulation on retinal vessel reactions using dynamic vessel analysis (DVA). Eighty healthy subjects were randomly assigned to one of three groups receiving electrical stimulation with different current intensities: 400 μA (n = 26); 800 μA (n = 27); 1200 μA (n = 27). The electrode montage for electrical stimulation consisted of a ring-shaped active electrode surrounding one eye and a square return electrode at the occiput. Rectangular, monophasic, positive current pulses were applied at 10 Hz for a duration of 60 s per stimulation period. DVA was used to observe the stimulation-induced reactions of retinal vessel diameters in response to different provocations. In three DVA measurements, three stimulus conditions were investigated: flicker light stimulation (FLS); electrical stimulation (ES); simultaneous electrical and flicker light stimulation (ES+FLS). Retinal vasodilation caused by these stimuli was compared using paired t-test. The subjects receiving electrical stimulation with 800 μA showed significantly increased retinal vasodilation for ES+FLS compared to FLS (p < 0.05). No significant differences in retinal vessel reactions were found between ES+FLS and FLS in the 400 and 1200 μA groups. No retinal vasodilation was observed for ES for all investigated current intensities. The results indicate that positive pulsed electrical stimulation of an adequate intensity enhances the flicker light-induced retinal vasodilation.

journal_name

Front Hum Neurosci

authors

Freitag S,Hunold A,Klemm M,Klee S,Link D,Nagel E,Haueisen J

doi

10.3389/fnhum.2019.00371

subject

Has Abstract

pub_date

2019-10-22 00:00:00

pages

371

issn

1662-5161

journal_volume

13

pub_type

杂志文章
  • Illuminating the dark matter of social neuroscience: Considering the problem of social interaction from philosophical, psychological, and neuroscientific perspectives.

    abstract::Successful human social interaction depends on our capacity to understand other people's mental states and to anticipate how they will react to our actions. Despite its importance to the human condition, the exact mechanisms underlying our ability to understand another's actions, feelings, and thoughts are still a mat...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2012.00190

    authors: Przyrembel M,Smallwood J,Pauen M,Singer T

    更新日期:2012-06-21 00:00:00

  • The neural basis of implicit perceptual sequence learning.

    abstract::The present fMRI study investigated the neural areas involved in implicit perceptual sequence learning. To obtain more insight in the functional contributions of the brain areas, we tracked both the behavioral and neural time course of the learning process, using a perceptual serial color matching task. Next, to inves...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2011.00137

    authors: Gheysen F,Van Opstal F,Roggeman C,Van Waelvelde H,Fias W

    更新日期:2011-11-11 00:00:00

  • Dissociation of category-learning systems via brain potentials.

    abstract::Behavioral, neuropsychological, and neuroimaging evidence has suggested that categories can often be learned via either an explicit rule-based (RB) mechanism critically dependent on medial temporal and prefrontal brain regions, or via an implicit information-integration (II) mechanism relying on the basal ganglia. In ...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2015.00389

    authors: Morrison RG,Reber PJ,Bharani KL,Paller KA

    更新日期:2015-07-07 00:00:00

  • Differential development of the ventral visual cortex extends through adolescence.

    abstract::The ventral temporal cortex (VTC) in humans includes functionally defined regions that preferentially respond to objects, faces, and places. Recent developmental studies suggest that the face selective region in the fusiform gyrus ('fusiform face area', FFA) undergoes a prolonged development involving substantial incr...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/neuro.09.080.2009

    authors: Golarai G,Liberman A,Yoon JM,Grill-Spector K

    更新日期:2010-02-22 00:00:00

  • Understanding visual consciousness in autism spectrum disorders.

    abstract::The paper focuses on the question of what the (visual) perceptual differences are between individuals with autism spectrum disorders (ASD) and typically developing (TD) individuals. We argue against the view that autistic subjects have a deficiency in the most basic form of perceptual consciousness-namely, phenomenal ...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2015.00204

    authors: Yatziv T,Jacobson H

    更新日期:2015-04-21 00:00:00

  • Retinotopic patterns of background connectivity between V1 and fronto-parietal cortex are modulated by task demands.

    abstract::Attention facilitates the processing of task-relevant visual information and suppresses interference from task-irrelevant information. Modulations of neural activity in visual cortex depend on attention, and likely result from signals originating in fronto-parietal and cingulo-opercular regions of cortex. Here, we tes...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2015.00338

    authors: Griffis JC,Elkhetali AS,Burge WK,Chen RH,Visscher KM

    更新日期:2015-06-08 00:00:00

  • "I didn't want to do it!" The detection of past intentions.

    abstract::In daily life and in courtrooms, people regularly analyze the minds of others to understand intentions. Specifically, the detection of intentions behind prior events is one of the main issues dealt with in courtrooms. To our knowledge, there are no experimental works focused on the use of memory detection techniques t...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2015.00608

    authors: Zangrossi A,Agosta S,Cervesato G,Tessarotto F,Sartori G

    更新日期:2015-11-05 00:00:00

  • Task-related functional connectivity dynamics in a block-designed visual experiment.

    abstract::Studying task modulations of brain connectivity using functional magnetic resonance imaging (fMRI) is critical to understand brain functions that support cognitive and affective processes. Existing methods such as psychophysiological interaction (PPI) and dynamic causal modeling (DCM) usually implicitly assume that th...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2015.00543

    authors: Di X,Fu Z,Chan SC,Hung YS,Biswal BB,Zhang Z

    更新日期:2015-09-30 00:00:00

  • Does docosahexaenoic acid supplementation in term infants enhance neurocognitive functioning in infancy?

    abstract::The proposal that dietary docosahexaenoic acid (DHA) enhances neurocognitive functioning in term infants is controversial. Theoretical evidence, laboratory research and human epidemiological studies have convincingly demonstrated that DHA deficiency can negatively impact neurocognitive development. However, the result...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnhum.2013.00774

    authors: Heaton AE,Meldrum SJ,Foster JK,Prescott SL,Simmer K

    更新日期:2013-11-20 00:00:00

  • Gender Differences in Food Choice: Effects of Superior Temporal Sulcus Stimulation.

    abstract::The easy availability of food has caused a shift from eating for survival to hedonic eating. Women, compared to men, have shown to respond differently to food cues in the environment on a behavioral and a neural level, in particular to energy rich (compared to low energy) foods. It has been demonstrated that the right...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2017.00597

    authors: Manippa V,Padulo C,van der Laan LN,Brancucci A

    更新日期:2017-12-07 00:00:00

  • Hyperactivation of the habenula as a link between depression and sleep disturbance.

    abstract::Depression occurs frequently with sleep disturbance such as insomnia. Sleep in depression is associated with disinhibition of the rapid eye movement (REM) sleep. Despite the coincidence of the depression and sleep disturbance, neural substrate for depressive behaviors and sleep regulation remains unknown. Habenula is ...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnhum.2013.00826

    authors: Aizawa H,Cui W,Tanaka K,Okamoto H

    更新日期:2013-12-10 00:00:00

  • Action video game play and transfer of navigation and spatial cognition skills in adolescents who are blind.

    abstract::For individuals who are blind, navigating independently in an unfamiliar environment represents a considerable challenge. Inspired by the rising popularity of video games, we have developed a novel approach to train navigation and spatial cognition skills in adolescents who are blind. Audio-based Environment Simulator...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2014.00133

    authors: Connors EC,Chrastil ER,Sánchez J,Merabet LB

    更新日期:2014-03-11 00:00:00

  • Habitual fat intake predicts memory function in younger women.

    abstract::High intakes of fat have been linked to greater cognitive decline in old age, but such associations may already occur in younger adults. We tested memory and learning in 38 women (25 to 45 years old), recruited for a larger observational study in women with polycystic ovary syndrome. These women varied in health statu...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2013.00838

    authors: Gibson EL,Barr S,Jeanes YM

    更新日期:2013-12-11 00:00:00

  • Training facilitates object recognition in cubist paintings.

    abstract::To the naïve observer, cubist paintings contain geometrical forms in which familiar objects are hardly recognizable, even in the presence of a meaningful title. We used fMRI to test whether a short training session about Cubism would facilitate object recognition in paintings by Picasso, Braque and Gris. Subjects, who...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/neuro.09.011.2010

    authors: Wiesmann M,Ishai A

    更新日期:2010-03-02 00:00:00

  • Distinct Brain and Behavioral Benefits from Cognitive vs. Physical Training: A Randomized Trial in Aging Adults.

    abstract::Insidious declines in normal aging are well-established. Emerging evidence suggests that non-pharmacological interventions, specifically cognitive and physical training, may counter diminishing age-related cognitive and brain functions. This randomized trial compared effects of two training protocols: cognitive traini...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2016.00338

    authors: Chapman SB,Aslan S,Spence JS,Keebler MW,DeFina LF,Didehbani N,Perez AM,Lu H,D'Esposito M

    更新日期:2016-07-18 00:00:00

  • Neurocognitive poetics: methods and models for investigating the neuronal and cognitive-affective bases of literature reception.

    abstract::A long tradition of research including classical rhetoric, esthetics and poetics theory, formalism and structuralism, as well as current perspectives in (neuro)cognitive poetics has investigated structural and functional aspects of literature reception. Despite a wealth of literature published in specialized journals ...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2015.00186

    authors: Jacobs AM

    更新日期:2015-04-16 00:00:00

  • The Relationship Between Attentional Capture by Speech and Nonfluent Speech Under Delayed Auditory Feedback: A Pilot Examination of a Dual-Task Using Auditory or Tactile Stimulation.

    abstract::Delayed auditory feedback (DAF) leads to nonfluent speech where the voice of a speaker is heard after a delay. Previous studies suggested the involvement of attention to auditory feedback in speech disfluency. To date, there are no studies that have revealed the relationship between attention and nonfluent speech by c...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2020.00051

    authors: Ishida O,Iimura D,Miyamoto S

    更新日期:2020-02-26 00:00:00

  • Towards a Multimodal Model of Cognitive Workload Through Synchronous Optical Brain Imaging and Eye Tracking Measures.

    abstract::Recent advances in neuroimaging technologies have rendered multimodal analysis of operators' cognitive processes in complex task settings and environments increasingly more practical. In this exploratory study, we utilized optical brain imaging and mobile eye tracking technologies to investigate the behavioral and neu...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2019.00375

    authors: İşbilir E,Çakır MP,Acartürk C,Tekerek AŞ

    更新日期:2019-10-23 00:00:00

  • Diverse sources of reward value signals in the basal ganglia nuclei transmitted to the lateral habenula in the monkey.

    abstract::The lateral habenula (LHb) plays an important role in motivational decision making. Neurons in the primate LHb signal negative 'reward prediction errors' and inhibit midbrain dopamine (DA) neurons. These negative reward prediction error signals in the LHb are, at least partly, provided by a distinct group of neurons i...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2013.00778

    authors: Hong S,Hikosaka O

    更新日期:2013-11-13 00:00:00

  • Automatic processing of unattended object features by functional connectivity.

    abstract::Observers can selectively attend to object features that are relevant for a task. However, unattended task-irrelevant features may still be processed and possibly integrated with the attended features. This study investigated the neural mechanisms for processing both task-relevant (attended) and task-irrelevant (unatt...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2013.00193

    authors: Mayer KM,Vuong QC

    更新日期:2013-05-15 00:00:00

  • Age-Related Structural Alterations in Human Amygdala Networks: Reflections on Correlations Between White Matter Structure and Effective Connectivity.

    abstract::The amygdala, which is involved in human social information processing and socio-emotional response neuronal circuits, is segmented into three subregions that are responsible for perception, affiliation, and aversion. Though there is different functional and effective connectivity (EC) among these networks, age-relate...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2019.00214

    authors: Jiang Y,Tian Y,Wang Z

    更新日期:2019-07-05 00:00:00

  • Characterizing aging in the human brainstem using quantitative multimodal MRI analysis.

    abstract::Aging is ubiquitous to the human condition. The MRI correlates of healthy aging have been extensively investigated using a range of modalities, including volumetric MRI, quantitative MRI (qMRI), and diffusion tensor imaging. Despite this, the reported brainstem related changes remain sparse. This is, in part, due to t...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2013.00462

    authors: Lambert C,Chowdhury R,Fitzgerald TH,Fleming SM,Lutti A,Hutton C,Draganski B,Frackowiak R,Ashburner J

    更新日期:2013-08-20 00:00:00

  • The influence of the amplitude of low-frequency fluctuations on resting-state functional connectivity.

    abstract::Studies of brain functional connectivity have provided a better understanding of organization and integration of large-scale brain networks. Functional connectivity using resting-state functional magnetic resonance imaging (fMRI) is typically based upon the correlations of the low-frequency fluctuation of fMRI signals...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2013.00118

    authors: Di X,Kim EH,Huang CC,Tsai SJ,Lin CP,Biswal BB

    更新日期:2013-04-02 00:00:00

  • Electrocorticographic Activation within Human Auditory Cortex during Dialog-Based Language and Cognitive Testing.

    abstract::Current models of cortical speech and language processing include multiple regions within the temporal lobe of both hemispheres. Human communication, by necessity, involves complex interactions between regions subserving speech and language processing with those involved in more general cognitive functions. To assess ...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2016.00202

    authors: Nourski KV,Steinschneider M,Rhone AE

    更新日期:2016-05-04 00:00:00

  • Modulations of ongoing alpha oscillations predict successful short-term visual memory encoding.

    abstract::Alpha-frequency band oscillations have been shown to be one of the most prominent aspects of neuronal ongoing oscillatory activity, as reflected by electroencephalography (EEG) recordings. First thought to reflect an idling state, a recent framework indicates that alpha power reflects cortical inhibition. In the prese...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2012.00127

    authors: Nenert R,Viswanathan S,Dubuc DM,Visscher KM

    更新日期:2012-05-08 00:00:00

  • Corrigendum: Higher integrity of the motor and visual pathways in long-term video game players.

    abstract::[This corrects the article DOI: 10.3389/fnhum.2015.00098.]. ...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章,已发布勘误

    doi:10.3389/fnhum.2019.00125

    authors: Zhang Y,Du G,Yang Y,Qin W,Li X,Zhang Q

    更新日期:2019-04-09 00:00:00

  • Histological Confirmation of Myelinated Neural Filaments Within the Tip of the Neurotrophic Electrode After a Decade of Neural Recordings.

    abstract:Aim:Electrodes that provide brain to machine or computer interfacing must survive the lifetime of the person to be considered an acceptable prosthetic. The electrodes may be external such as with electroencephalographic (EEG), internal extracortical such as electrocorticographic (ECoG) or intracortical. Methods:Most i...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2020.00111

    authors: Gearing M,Kennedy P

    更新日期:2020-04-21 00:00:00

  • Decreased small-world functional network connectivity and clustering across resting state networks in schizophrenia: an fMRI classification tutorial.

    abstract::Functional network connectivity (FNC) is a method of analyzing the temporal relationship of anatomical brain components, comparing the synchronicity between patient groups or conditions. We use functional-connectivity measures between independent components to classify between Schizophrenia patients and healthy contro...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2013.00520

    authors: Anderson A,Cohen MS

    更新日期:2013-09-02 00:00:00

  • Semantic Processing in Autism Spectrum Disorders Is Associated With the Timing of Language Acquisition: A Magnetoencephalographic Study.

    abstract::Individuals with autism show difficulties in using sentence context to identify the correct meaning of ambiguous words, such as homonyms. In this study, the brain basis of sentence context effects on word understanding during reading was examined in autism spectrum disorder (ASD) and typical development (TD) using mag...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2020.00267

    authors: Ahtam B,Braeutigam S,Bailey A

    更新日期:2020-07-10 00:00:00

  • Optokinetic stimulation modulates neglect for the number space: evidence from mental number interval bisection.

    abstract::Behavioral, neuropsychological, and neuroimaging data support the idea that numbers are represented along a mental number line (MNL), an analogical, visuospatial representation of number magnitude. The MNL is left-to-right oriented in Western cultures, with small numbers on the left and larger numbers on the right. Le...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2012.00023

    authors: Priftis K,Pitteri M,Meneghello F,Umiltà C,Zorzi M

    更新日期:2012-02-20 00:00:00