Tumefactive Demyelinating Lesions and Pregnancy.

Abstract:

:Until now, only one gestational tumefactive demyelinating lesion (TDL) has been described. Here we report two TDL cases occurring during and after the pregnancy. A 26-year-old 6-week pregnant woman developed a 3-cm left frontotemporoparietal subcortical TDL with inhomogeneous partial enhancement. Brain biopsy revealed a subacute demyelinating lesion with abundant macrophages and mild chronic perivascular inflammatory infiltrates. She also had femoralpopliteal deep vein thrombosis. During the 4-year follow-up, magnetic resonance imaging showed only residual biopsied TDL. The second case was a 41-year-woman affected by both multiple sclerosis (MS) and rheumatoid arthritis who developed a 2-cm right anterior corona radiata TDL with sporadic gadolinium-enhancing "annular spots" eight months after delivery. After steroid therapy at the 6-month radiological follow-up, this TDL was half-reduced. Five years earlier, at the beginning of her MS, she already had a 2-cm TDL with incomplete ring enhancement. These two described TDLs formed in prothrombotic conditions and were likely representative of thromboinflammation around and inside the small-medium veins.

journal_name

Neurol India

journal_title

Neurology India

authors

Plantone D,Piantadosi C,Ruggieri S,Anelli V,Koudriavtseva T

doi

10.4103/0028-3886.273654

subject

Has Abstract

pub_date

2019-11-01 00:00:00

pages

1519-1521

issue

6

eissn

0028-3886

issn

1998-4022

pii

ni_2019_67_6_1519_273654

journal_volume

67

pub_type

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