Saccadic delay in multiple sclerosis: A quantitative description.

Abstract:

:In multiple sclerosis (MS), eye movement disorders are common and can be quantified with infrared video-oculography. A well-known abnormality is internuclear ophthalmoplegia (INO). This study aims to describe saccadic abnormalities beyond INO and investigate their clinical relevance. A validated standardized infrared oculography protocol, DEMoNS, was used for quantifying saccadic eye movements in three different tasks in MS patients and healthy controls. The relationship between the saccadic parameters and disease characteristics was investigated. Furthermore, the association between saccadic parameters and visual functioning was analysed using logistic regression models, adjusted for possible confounders. This cross-sectional study included 218 subjects with MS and 58 healthy controls. The latency of all saccades was longer in MS patients than in healthy controls. This saccadic delay was larger in subjects with a longer disease duration and more disabled subjects. Furthermore, it was significantly related to presence of a lower vision-related quality of life. This study provided a comprehensive overview of performance of MS patients in different saccadic tasks, compared to healthy controls. Saccadic delay in MS patients was present in all saccadic tasks and was related to advancing disease and visual functioning in daily life.

journal_name

Vision Res

journal_title

Vision research

authors

Nij Bijvank JA,Petzold A,Coric D,Tan HS,Uitdehaag BMJ,Balk LJ,van Rijn LJ

doi

10.1016/j.visres.2020.01.003

subject

Has Abstract

pub_date

2020-03-01 00:00:00

pages

33-41

eissn

0042-6989

issn

1878-5646

pii

S0042-6989(20)30005-5

journal_volume

168

pub_type

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