当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY期刊下所有文献 > Airway response to sirolimus therapy for the treatment of complex pediatric lymphatic malformations.

Airway response to sirolimus therapy for the treatment of complex pediatric lymphatic malformations.

Abstract：

:Head and neck lymphatic malformations can create airway management challenges requiring tracheotomy. Sirolimus, an inhibitor of mammalian target of rapamycin (mTOR), may inhibit growth of lymphatic malformations. We describe two patients born with large lymphatic malformations with improved airway symptoms following sirolimus therapy. Patient #1 underwent tracheotomy and multi-modal therapy including sirolimus with reduction in airway involvement but regrowth after discontinuation of sirolimus. Patient #2 also experienced a significant response to sirolimus allowing for extubation and discharge without tracheotomy. Early initiation of sirolimus therapy should be considered as a means to avoid tracheotomy in complex head and neck lymphatic malformations.

journal_name

Int J Pediatr Otorhinolaryngol

journal_title

International journal of pediatric otorhinolaryngology

authors

Alemi AS,Rosbe KW,Chan DK,Meyer AK

doi

10.1016/j.ijporl.2015.10.031

subject

Has Abstract

pub_date

2015-12-01 00:00:00

pages

2466-9

issue

12

eissn

0165-5876

issn

1872-8464

pii

S0165-5876(15)00538-8

journal_volume

79

pub_type

杂志文章

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