Use of Microbiota to Fight Mosquito-Borne Disease.

abstract：:Taproot skin color is a crucial visual and nutritional quality trait of radish, and purple skin is most attractive to consumers. However, the genetic mechanism underlying this character is unknown. Herein, F2 segregating populations were constructed to investigate radish genomic regions with purple skin genes. Segrega...

journal_title：Frontiers in genetics

authors： Liu T,Wang J,Wu C,Zhang Y,Zhang X,Li X,Wang H,Song J,Li X

更新日期：2019-09-20 00:00:00

abstract：:Background and aims: Obesity is a major health problem worldwide. Given the heterogeneous obesity phenotype, an optimal obesity stratification would improve clinical management. Since obesity has a strong genetic component, we aimed to develop a polygenic risk score (PRS) to stratify obesity according to the genetic b...

journal_title：Frontiers in genetics

authors： de Toro-Martín J,Guénard F,Bouchard C,Tremblay A,Pérusse L,Vohl MC

更新日期：2019-10-10 00:00:00

abstract：:The formation mechanism underlying the blue eggshell characteristic has been discovered in birds, and SLCO1B3 is the key gene that regulates the blue eggshell color. Insertion of an endogenous retrovirus, EAV-HP, in the SLCO1B3 5' flanking region promotes SLCO1B3 expression in the chicken shell gland, and this express...

journal_title：Frontiers in genetics

authors： Li Z,Ren T,Li W,Zhou Y,Han R,Li H,Jiang R,Yan F,Sun G,Liu X,Tian Y,Kang X

更新日期：2019-02-26 00:00:00

abstract：:The new class of rare variant tests has usually been evaluated assuming perfect genotype information. In reality, rare variant genotypes may be incorrect, and so rare variant tests should be robust to imperfect data. Errors and uncertainty in SNP genotyping are already known to dramatically impact statistical power fo...

journal_title：Frontiers in genetics

authors： Cook K,Benitez A,Fu C,Tintle N

更新日期：2014-04-01 00:00:00

abstract：:Exosomes are biomolecular nanostructures released from cells. They carry specific biomolecular information and are mainly researched for their exquisite properties as a biomarker source and delivery system. We introduce exosomes in the context of other extracellular vesicles, describe their biophysical isolation and c...

journal_title：Frontiers in genetics

authors： de la Torre Gomez C,Goreham RV,Bech Serra JJ,Nann T,Kussmann M

更新日期：2018-03-27 00:00:00

abstract：:Molecular epidemiological studies have identified several risk factors linking to the genes and external factors in the pathogenesis of breast cancer. In this sense, genetic instability caused by DNA damage and DNA repair inefficiencies are important molecular events for the diagnosis and prognosis of therapies. There...

journal_title：Frontiers in genetics

authors： Paz MFCJ,de Alencar MVOB,Gomes Junior AL,da Conceição Machado K,Islam MT,Ali ES,Shill MC,Ahmed MI,Uddin SJ,da Mata AMOF,de Carvalho RM,da Conceição Machado K,Sobral ALP,da Silva FCC,de Castro E Souza JM,Arcanjo DDR,Ferrei

更新日期：2018-02-16 00:00:00

abstract：:Circadian rhythms produce a biological measure of the time of day. In plants, circadian regulation forms an essential adaptation to the fluctuating environment. Most of our knowledge of the molecular aspects of circadian regulation in plants is derived from laboratory experiments that are performed under controlled co...

journal_title：Frontiers in genetics

authors： Panter PE,Muranaka T,Cuitun-Coronado D,Graham CA,Yochikawa A,Kudoh H,Dodd AN

更新日期：2019-11-29 00:00:00

abstract：:Classification of DNA sequences is an important issue in the bioinformatics study, yet most existing methods for phylogenetic analysis including Multiple Sequence Alignment (MSA) are time-consuming and computationally expensive. The alignment-free methods are popular nowadays, whereas the manual intervention in those ...

journal_title：Frontiers in genetics

authors： Dong R,He L,He RL,Yau SS

更新日期：2019-04-09 00:00:00

abstract：:As one of the hotspot regions for sympatric speciation studies, Evolution Canyon (EC) became an ideal place for its high level of microclimatic divergence interslopes. In this study, to highlight the genetic mechanisms of sympatric speciation, phenotypic variation on flowering time and transcriptomic divergence were i...

journal_title：Frontiers in genetics

authors： Qian C,Yan X,Yin H,Fan X,Yin X,Sun P,Li Z,Nevo E,Ma XF

更新日期：2018-11-14 00:00:00

abstract：:RNA binding proteins (RBPs) play a key role in post-transcriptional gene regulation. They have been shown to be dysfunctional in a variety of cancers and are closely related to the occurrence and progression of cancers. However, the biological function and clinical significance of RBPs in clear cell renal carcinoma (c...

journal_title：Frontiers in genetics

authors： Wu Y,Wei X,Feng H,Hu B,Liu B,Luan Y,Ruan Y,Liu X,Liu Z,Wang S,Liu J,Wang T

更新日期：2021-01-07 00:00:00

abstract：:The vicuña (Vicugna vicugna) is the most representative wild ungulate of the high Andes of South America with two recognized morphological subspecies, V. v. mensalis in the north and V. v. vicugna in the south of its distribution. Current vicuña population size (460,000-520,000 animals) is the result of population rec...

journal_title：Frontiers in genetics

authors： González BA,Vásquez JP,Gómez-Uchida D,Cortés J,Rivera R,Aravena N,Chero AM,Agapito AM,Varas V,Wheleer JC,Orozco-terWengel P,Marín JC

更新日期：2019-06-06 00:00:00

abstract：:The goal of this work was to determine the effect of nonablative syngeneic transplantation of young bone marrow (BM) to laboratory animals (mice) of advanced age upon maximum duration of their lifespan. To do this, transplantation of 100 million nucleated cells from BM of young syngeneic donors to an old nonablated an...

journal_title：Frontiers in genetics

authors： Kovina MV,Karnaukhov AV,Krasheninnikov ME,Kovin AL,Gazheev ST,Sergievich LA,Karnaukhova EV,Bogdanenko EV,Balyasin MV,Khodarovich YM,Dyuzheva TG,Lyundup AV

更新日期：2019-04-12 00:00:00

abstract：:The Jats represent a large ethnic community that has inhabited the northwest region of India and Pakistan for several thousand years. It is estimated the community has a population of over 123 million people. Many historians and academics have asserted that the Jats are descendants of Aryans, Scythians, or other ancie...

journal_title：Frontiers in genetics

authors： Mahal DG,Matsoukas IG

更新日期：2017-09-20 00:00:00

abstract：:Recent advances in genomics and proteomics generated a large amount of trans regulatory data such as those mediated by RNA binding proteins (RBPs) and microRNAs. Since many trans regulators target 3' UTR of mRNA transcripts, it is likely that there would be interactions, i.e., competitive or cooperative effect, among ...

journal_title：Frontiers in genetics

authors： Liu Y,Pan C,Kong D,Luo J,Zhang Z

更新日期：2020-09-08 00:00:00

abstract：:Recently, an increasing number of studies sequence multiple biopsies of primary tumors, and even paired metastatic tumors to understand heterogeneity and the evolutionary trajectory of cancer progression. Although several algorithms are available to infer the phylogeny, most tools rely on accurate measurements of muta...

journal_title：Frontiers in genetics

authors： Wu P,Hou L,Zhang Y,Zhang L

更新日期：2020-02-07 00:00:00

abstract：:The identification of functional modules in gene interaction networks is a key step in understanding biological processes. Network interpretation is essential for unveiling biological mechanisms, candidate biomarkers, or potential targets for drug discovery/repositioning. Plenty of biological module identification alg...

journal_title：Frontiers in genetics

authors： Nazzicari N,Vella D,Coronnello C,Di Silvestre D,Bellazzi R,Marini S

更新日期：2019-10-09 00:00:00

abstract：:Lumbar disc degeneration (LDD) is age-related break-down in the fibrocartilaginous joints between lumbar vertebrae. It is a major cause of low back pain and is conventionally assessed by magnetic resonance imaging (MRI). Like most other complex traits, LDD is likely polygenic and influenced by both genetic and environ...

journal_title：Frontiers in genetics

authors： Zhou X,Cheung CL,Karasugi T,Karppinen J,Samartzis D,Hsu YH,Mak TS,Song YQ,Chiba K,Kawaguchi Y,Li Y,Chan D,Cheung KM,Ikegawa S,Cheah KS,Sham PC

更新日期：2018-08-03 00:00:00

abstract：:Gene expression profiling has been widely used to characterize cell status to reflect the health of the body, to diagnose genetic diseases, etc. In recent years, although the cost of genome-wide expression profiling is gradually decreasing, the cost of collecting expression profiles for thousands of genes is still ver...

journal_title：Frontiers in genetics

authors： Li W,Yin Y,Quan X,Zhang H

更新日期：2019-11-12 00:00:00

abstract：:Hexavalent chromium [Cr(VI)] is a well-known occupational carcinogen, but the mechanisms contributing to DNA damage and cell cycle alternation have not been fully characterized. To study the dose-response effects of Cr(VI) on transcription, we exposed BEAS-2B cells to Cr(VI) at concentrations of 0.2, 0.6, and 1.8 μmol...

journal_title：Frontiers in genetics

authors： Zheng P,Kang Y,Han S,Feng H,Ha F,Long C,Zhou D,Hu G,Chen Z,Wang Z,Wang T,Jia G

更新日期：2021-01-13 00:00:00

abstract：:A biochemical activity, that is, enzymatic reaction or molecular interaction, frequently involves a molecule, for example, an enzyme, capable of interacting with numerous substrates or partners. Specificity is a fundamental property of biochemical activities, and relative specificity refers to the situation whereby a ...

journal_title：Frontiers in genetics

authors： Zeng Y

更新日期：2011-09-20 00:00:00

abstract：:Post-translational methylation of H3 lysine 36 (H3K36) is an important epigenetic marker that majorly contributes to the functionality of the chromatin. This mark is interpreted by the cell in several crucial biological processes including gene transcription and DNA methylation. The homeostasis of H3K36 methylation is...

journal_title：Frontiers in genetics

authors： Zaghi M,Broccoli V,Sessa A

更新日期：2020-01-09 00:00:00

abstract：:Challenges in diagnosing primary immunodeficiency are numerous and diverse, with current whole-exome and whole-genome sequencing approaches only able to reach a molecular diagnosis in 25-60% of cases. We assess these problems and discuss how RNA-focused analysis has expanded and improved in recent years and may now be...

journal_title：Frontiers in genetics

authors： Lye JJ,Williams A,Baralle D

更新日期：2019-12-11 00:00:00

abstract：Background:Cross-sectional observational studies have reported obesity and cardiometabolic co-morbidities as important predictors of coronavirus disease 2019 (COVID-19) hospitalization. The causal impact of these risk factors is unknown at present. Methods:We conducted multivariable logistic regression to evaluate the...

journal_title：Frontiers in genetics

authors： Aung N,Khanji MY,Munroe PB,Petersen SE

更新日期：2020-11-11 00:00:00

abstract：:In 1994, it was suggested that AGG interruptions affect the stability of the fragile X triplet repeat. Until recently, however, this hypothesis was not explored on a large scale due primarily to the technical difficulty of determining AGG interruption patterns of the two alleles in females. The recent development of a...

journal_title：Frontiers in genetics

authors： Latham GJ,Coppinger J,Hadd AG,Nolin SL

更新日期：2014-07-29 00:00:00

abstract：:Genomic breed composition (GBC) of an individual animal refers to the partition of its genome according to the inheritance from its ancestors or ancestral breeds. For crossbred or composite animals, knowing their GBC is useful to estimate heterosis, to characterize their actual inheritance from foundation breeds, and ...

journal_title：Frontiers in genetics

authors： Wu XL,Li Z,Wang Y,He J,Rosa GJM,Ferretti R,Genho J,Tait RG Jr,Parham J,Schultz T,Bauck S

更新日期：2020-10-30 00:00:00

abstract：:Accurate inference of causal gene regulatory networks from gene expression data is an open bioinformatics challenge. Gene interactions are dynamical processes and consequently we can expect that the effect of any regulation action occurs after a certain temporal lag. However such lag is unknown a priori and temporal a...

journal_title：Frontiers in genetics

authors： Lopes M,Bontempi G

更新日期：2013-12-24 00:00:00

abstract：:Leukocyte telomere length is believed to measure cellular aging in humans, and short leukocyte telomere length is associated with increased risks of late onset diseases, including cardiovascular disease, dementia, etc. Many studies have shown that leukocyte telomere length is a heritable trait, and several candidate g...

journal_title：Frontiers in genetics

authors： Lee JH,Cheng R,Honig LS,Feitosa M,Kammerer CM,Kang MS,Schupf N,Lin SJ,Sanders JL,Bae H,Druley T,Perls T,Christensen K,Province M,Mayeux R

更新日期：2014-01-17 00:00:00

abstract：:Long non-coding RNAs (lncRNAs) are recognized as an important class of regulatory molecules involved in a variety of biological functions. However, the regulatory mechanisms of long non-coding genes expression are still poorly understood. The characterization of the genomic features of lncRNAs is crucial to get insigh...

journal_title：Frontiers in genetics

authors： Abou Alezz M,Celli L,Belotti G,Lisa A,Bione S

更新日期：2020-05-15 00:00:00

abstract：:DNA methylation is an indispensable epigenetic modification that dynamically regulates gene expression and genome stability during cell growth and development processes. The target of rapamycin (TOR) has emerged as a central regulator to regulate many fundamental cellular metabolic processes from protein synthesis to ...

journal_title：Frontiers in genetics

authors： Zhu T,Li L,Feng L,Mo H,Ren M

更新日期：2020-03-03 00:00:00

abstract：:Filet quality traits determine consumer satisfaction and affect profitability of the aquaculture industry. Soft flesh is a criterion for fish filet downgrades, resulting in loss of value. Filet firmness is influenced by many factors, including rate of protein turnover. A 50K transcribed gene SNP chip was used to genot...

journal_title：Frontiers in genetics

authors： Ali A,Al-Tobasei R,Lourenco D,Leeds T,Kenney B,Salem M

更新日期：2019-05-03 00:00:00