Abstract：
STUDY DESIGN:Descriptive study. OBJECTIVES:The goal of this study was to determine the effects of spinal cord injury (SCI) on aspects of the focal adhesion kinase (FAK) signaling pathway 56 days post injury in rat gastrocnemius. SETTING:This study was conducted in Bronx, NY, USA. METHODS:Three-month-old male Wistar rats were exposed to either a sham surgery (n=10) or complete T4 spinal cord transection (n=10). Rats were killed 56 days following surgery and the muscle was collected. Following homogenization, proteins of the FAK pathway were analyzed by western immunoblotting or reverse transcription-qPCR. In addition, cellular markers for proteins that target the degradation of FAK were investigated. RESULTS:SCI resulted in significantly lower levels of total and phosphorylated FAK, cSrc and p70S6k, and a trend for increased FRNK protein expression. SCI did not change levels of the α7 or β1 integrin subunits, total or phosphorylated ERK1/2, phosphorylated Akt and TSC2 or total p70S6k. SCI resulted in a greater expression of total Akt. mRNA expression of FAK and the α7 or β1 integrins remained unchanged between sham and SCI groups. Caspase-3/7 activity and Trim72 mRNA and protein expression remained unchanged following SCI. CONCLUSION:SCI results in diminished FAK signaling and is independent of ERK1/2 and Akt. SCI has no effect on mRNA levels for genes encoding components of the focal adhesion 56 days after injury.
journal_name
Spinal Cordjournal_title
Spinal cordauthors
Graham ZA,Qin W,Harlow LC,Ross NH,Bauman WA,Gallagher PM,Cardozo CPdoi
10.1038/sc.2015.183subject
Has Abstractpub_date
2016-07-01 00:00:00pages
502-9issue
7eissn
1362-4393issn
1476-5624pii
sc2015183journal_volume
54pub_type
杂志文章相关文献
SPINAL CORD文献大全abstract：OBJECTIVES:Hereditary spastic paraplegia (HSP) is a degenerative central nervous system disorder characterized by progressive spasticity and hyperreflexia of the lower limbs. Often, patients with HSP experience symptoms of voiding dysfunction. Urodynamic evaluations of these patients are rarely reported in the literatu...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sc.2011.193
更新日期：2012-07-01 00:00:00
abstract：STUDY DESIGN:A combination of review of case notes and outpatient follow-up. OBJECTIVE:To evaluate the effectiveness of the modified Girdlestones-Taylor procedure in patients with spinal cord injury (SCI). SETTING:Princess Royal Spinal Injuries Centre (PRSIC), Northern General Hospital, Sheffield, UK. METHODS:Nine p...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sj.sc.3101924
更新日期：2006-12-01 00:00:00
abstract：STUDY DESIGN:Human tails continue to elicit curiosity till the present times. A unique case of human cervical dysraphism is described. OBJECTIVES:In addition to the cosmetic stigma, these cutaneous markers provide a lead to reach the underlying spinal dysraphic states. SETTING:Plains of North India. METHODS:A case o...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sj.sc.3101988
更新日期：2007-08-01 00:00:00
abstract：:Epidural spinal cord stimulation has been used to decrease spasticity and spasms in spinal cord injury patients. However, the long-term benefits of this procedure have not been determined. We therefore conducted a retrospective study of the possible long-term efficacy of the epidural spinal cord stimulator for the rel...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sj.sc.3100532
更新日期：1998-03-01 00:00:00
abstract：STUDY DESIGN:A cross-sectional survey. OBJECTIVES:To document bowel care practices of chronic spinal cord injury (SCI) patients in Pakistan. SETTINGS:Outpatient Department, Armed Forces Institute of Rehabilitation Medicine, Rawalpindi, Pakistan. METHODS:A total of 50 adult patients (18-65 years) with SCI of duration...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sc.2010.46
更新日期：2010-12-01 00:00:00
abstract：STUDY DESIGN:A prospective intervention of noninvasive abdominal massage using an electromechanical apparatus on bowel function in individuals with spinal cord injury (SCI). OBJECTIVES:To evaluate the effects of noninvasive abdominal massage using an electromechanical apparatus on bowel function in individuals with SC...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sc.2014.101
更新日期：2014-09-01 00:00:00
abstract：:Restless legs syndrome (RLS) is a well-defined symptom complex, occurring either as idiopathic RLS or in association with many other disorders. Although no definite etiology is known for this condition, several pathophysiological mechanisms have been proposed. There is supportive evidence that RLS is a central nervous...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sj.sc.3100929
更新日期：1999-12-01 00:00:00
abstract：AIM OF STUDY:Clean intermittent self catheterisation (CISC) is commonly used by patients with impaired bladder emptying. But how to manage acute false passages in patients on CISC? METHODS:Six patients experienced difficulty when performing intermittent catheterisation. Urethrocystoscopy demonstrated a new false passa...
journal_title：Spinal cord
pub_type： 临床试验,杂志文章
doi：10.1038/sj.sc.3100789
更新日期：1999-03-01 00:00:00
abstract：STUDY DESIGN:Open label study to determine drug dose for a randomized double-blind placebo-controlled parallel study. OBJECTIVES:To assess the efficacy and side effects of oral Delta(9)-tetrahydrocannabinol (THC) and rectal THC-hemisuccinate (THC-HS) in SCI patients. SETTING:REHAB Basel, Switzerland. METHOD:Twenty-f...
journal_title：Spinal cord
pub_type： 杂志文章,随机对照试验
doi：10.1038/sj.sc.3101982
更新日期：2007-08-01 00:00:00
abstract：STUDY DESIGN:The paper describes a technique for complete vertebrectomy and spinal cord decompression, followed by a formal anterior column reconstruction, using endoscopic instruments. This procedure is indicated for patients with radioresistant metastasis of the thoracic spine, particularly those involving the upper ...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sj.sc.3101194
更新日期：2001-09-01 00:00:00
abstract：STUDY DESIGN:Randomized, assessor-blinded trial. OBJECTIVES:To evaluate the effectiveness of a 6-week task-specific training programme on the abilities of people with chronic spinal cord injuries to sit unsupported. SETTING:NSW, Australia. METHODS:Thirty adults with spinal cord injuries of at least 1-year duration w...
journal_title：Spinal cord
pub_type： 杂志文章,随机对照试验
doi：10.1038/sc.2009.88
更新日期：2010-02-01 00:00:00
abstract：OBJECTIVES:To assess the urodynamic and clinical outcome of a laparoscopic auto-augmentated bladder. METHODS:Laparoscopic bladder autoaugmentation in a 27-year-old woman with an incomplete spinal cord injury at T12 level with urge incontinence caused by a hyperreflexic bladder. RESULTS:Six months later the patient vo...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sj.sc.3100939
更新日期：2000-01-01 00:00:00
abstract：STUDY DESIGN:Retrospective chart audit. OBJECTIVES:Firstly determining the prevalence of scoliosis in myelomeningocele (MMC) patients of the University Hospitals Leuven. Secondly analyzing whether there are differences concerning distribution of radiological level, ambulatory status, hydrocephalus, tethered cord, and ...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/s41393-020-00611-3
更新日期：2021-01-25 00:00:00
abstract：OBJECTIVE:To provide an overview of our current understanding of the problem of neuropathic pain following spinal cord injury (SCI) and to suggest possible therapeutic options in the near future. METHODS:Original research articles, reviews and book chapters on the subject of pain and SCI. RESULTS:Neuropathic pain fol...
journal_title：Spinal cord
pub_type： 杂志文章,评审
doi：10.1038/sc.2008.136
更新日期：2009-05-01 00:00:00
abstract：STUDY DESIGN:Prospective, observational OBJECTIVES: To evaluate agreement between a reference method (doubly labelled water, DLW) of total energy expenditure (TEE) and published equations for estimating energy requirements in acute spinal cord injury (SCI). SETTING:Victoria, Australia METHODS: Twenty participants (18 ...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/s41393-019-0253-9
更新日期：2019-07-01 00:00:00
abstract：STUDY DESIGN:A randomized, blinded, crossover clinical trial comparing sildenafil versus tadalafil for erectile dysfunction (ED) in male spinal cord-injured (SCI) patients. OBJECTIVES:To compare the safety, time/duration effectiveness, and the impact on the quality of life (QoL) of tadalafil 10 mg versus sildenafil 50...
journal_title：Spinal cord
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1038/sj.sc.3101617
更新日期：2004-11-01 00:00:00
abstract：OBJECTIVES:To validate the Screening Tool for the Assessment of Malnutrition in Paediatrics (STAMP) in paediatric spinal cord injuries (SCIs) patients admitted to the tertiary SCI centre. METHODS:children's baseline clinical data, anthropometric measurements and STAMP score were assessed on admission. The validity of ...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sc.2012.166
更新日期：2013-05-01 00:00:00
abstract：STUDY DESIGN:Repeated measures design. OBJECTIVES:To determine the reproducibility of total-body and regional-body composition assessments from a total-body scan using dual-energy x-ray absorptiometry (DXA) in persons with spinal cord injury (SCI). METHODS:Twenty-four individuals with SCI completed within-day short-t...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/s41393-018-0079-x
更新日期：2018-10-01 00:00:00
abstract：STUDY DESIGN:Observational cross-sectional study. OBJECTIVES:To describe the most common prescription medications used and the extent of out-of-pocket cost, insurance coverage, and cost-related nonadherence (CRNA) for those medications by people with spinal cord injury (SCI) in Canada. SETTING:Community in Canada. M...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/s41393-019-0406-x
更新日期：2020-05-01 00:00:00
abstract：STUDY DESIGN:Pictorial review. OBJECTIVES:To illustrate MRI signs of acute and subacute injury with emphasis on evidence-based links to clinical outcome and implications for treatment. METHODS:Description of important aspects of MRI techniques and illustration of critical MRI signs important in the assessment of spin...
journal_title：Spinal cord
pub_type： 杂志文章,评审
doi：10.1038/sc.2011.107
更新日期：2012-01-01 00:00:00
abstract：STUDY DESIGN:A cross-sectional study. OBJECTIVE:To assess the influence of various surfaces on the gait characteristics of ambulatory participants with incomplete spinal cord injury (SCI) as compared to data from able-bodied participants. SETTING:A tertiary rehabilitation center and communities. METHODS:Seventy part...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/s41393-019-0282-4
更新日期：2019-09-01 00:00:00
abstract：:This corrects the article DOI: 10.1038/sc.2016.7. ...
journal_title：Spinal cord
pub_type： 已发布勘误
doi：10.1038/sc.2017.32
更新日期：2017-07-01 00:00:00
abstract：STUDY DESIGN:A cross-sectional postal questionnaire study. OBJECTIVES:The aim of the study was to evaluate selected psychometric properties of a draft version of the Patient Participation in Rehabilitation Questionnaire (PPRQ) measuring patients' experiences of participation in care and rehabilitation. SETTING:Sweden...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sc.2013.98
更新日期：2013-11-01 00:00:00
abstract：STUDY DESIGN:Prospective multidimensional study by means of: (1) clinical assessment, (2) parental-administered questionnaire for general health (CHQ-PF50), and (3) standardised disability measurements. OBJECTIVES:To assess the health-related quality of life (QoL) and disability in children with spina bifida (SB) and ...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sj.sc.3101707
更新日期：2005-04-01 00:00:00
abstract：STUDY DESIGN:Survey. OBJECTIVES:Describe and compare the organisation and delivery of rehabilitation services and systems of care for patients with spinal cord injury (SCI). SETTING:International. Nine spinal rehabilitation units that manage traumatic SCI and non-traumatic SCI (NTSCI) patients. METHODS:Survey based ...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sc.2012.82
更新日期：2013-01-01 00:00:00
abstract：BACKGROUND:Despite evidence of the relationship between time use and health and well-being, and the World Health Organization's recognition of activity limitation as a measure of dis-ability, there has been limited investigation into the activity patterns of persons with disabilities. METHODS:Interviews and time diari...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sj.sc.3100908
更新日期：1999-11-01 00:00:00
abstract：STUDY DESIGN:The analysis of oxygen uptake (VO(2)) and energy consumption in quadriplegics after 6 months of treadmill gait with neuromuscular electrical stimulation (NMES). OBJECTIVES:To compare metabolic responses in quadriplegics after 6 months of treadmill training, with NMES (30-50% body weight relief), with quad...
journal_title：Spinal cord
pub_type： 临床试验,杂志文章
doi：10.1038/sj.sc.3101776
更新日期：2005-11-01 00:00:00
abstract：OBJECTIVES:The aim of this study was to investigate the pharmacological effects of long-term oral tadalafil treatment on the corpus cavernosum function in rats subjected to experimental spinal cord transection (SCT). METHODS:Thirty young adult, male Sprague–Dawley rats were randomly divided into five groups (n¼ 6, eac...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sc.2013.61
更新日期：2013-09-01 00:00:00
abstract：STUDY DESIGN:Cross-sectional comparison, control group. OBJECTIVES:To investigate the relationship between carotid arterial stiffness and circulating markers for cardiovascular disease (CVD) in spinal cord-injured (SCI) subjects compared with able-bodied (AB) individuals. SETTING:University Research Laboratory, Unive...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sc.2011.56
更新日期：2011-09-01 00:00:00
abstract：OBJECTIVE:To evaluate rehabilitation outcome in a representative sample of older and younger SCI patients. DESIGN:Case series, consecutive sample, survey. SETTING:Tertiary care, spinal cord injury unit (National Spinal Injuries Centre), Stoke Mandeville Hospital. PARTICIPANTS:One hundred and forty-seven male and 45 ...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sj.sc.3101386
更新日期：2003-01-01 00:00:00
