Abstract:
OBJECTIVE:Aortic valve calcification (AVC) reflects the state of aortic valve sclerosis (AVS), which is a precursor to aortic valve stenosis (AS). Therefore, we investigated the presence of AVC in patients who underwent coronary computed tomography angiography (CTA), which is an effective tool for evaluating early-stage AVC, and examined the association between plasma levels of pentraxin 3 (PTX3) and AVC. METHODS AND RESULTS:The subjects consisted of 162 consecutive patients who underwent CTA and in whom we could measure plasma levels of PTX3. We divided the patients into an AVC group (n=42) and a non-AVC group (n=120), as assessed by CT. Furthermore, we divided the patients without AS, assessed by echocardiography, into non-AS AVC (n=23) and non-AS non-AVC groups (n=60). We analyzed the predictors of the presence of AVC in all patients by a logistic regression analysis. AVC was independently associated with PTX3, in addition to age, chronic kidney disease, and coronary artery calcification. We also examined the predictors of the presence of AVC in patients without AS. PTX3, in addition to age, was an independent predictor of the presence of AVC in patients without AS. Finally, we found that adding PTX3 to the model containing age improves the specificity and, therefore, positive predictive value for AVC. CONCLUSIONS:PTX3, in addition to age, was shown to be an independent predictor of AVC in patients without AS. The combination of age and PTX3 may be a better approach to the evaluation of AVC than either of these alone.
journal_name
J Cardioljournal_title
Journal of cardiologyauthors
Norimatsu K,Miura S,Suematsu Y,Shiga Y,Miyase Y,Nakamura A,Zhang B,Saku Kdoi
10.1016/j.jjcc.2015.08.010subject
Has Abstractpub_date
2016-07-01 00:00:00pages
76-82issue
1eissn
0914-5087issn
1876-4738pii
S0914-5087(15)00267-1journal_volume
68pub_type
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