Recurring Multicentric Granulomatous Cryptococcomas in the Contralateral Cerebral Hemisphere in an Adult Immunocompetent Patient with Known Previous Disease.

Abstract:

BACKGROUND:Fungal mass lesions in the central nervous system rarely reach a size large enough to directly cause neurologic deterioration. In terms of the etiologic incidence of fungal mass lesions in the central nervous system, whereas cryptococcomas may be the most common, they rarely reach any appreciable size. One form of this specific fungal infection, namely the granulomatous form of cryptococcomatosis, challenges this paradigm, and these lesions can reach an alarming size. CASE DESCRIPTION:We previously reported a case of multicentric granulomatous cryptococcomas occurring in an adult immunocompetent male patient published in WORLD NEUROSURGERY in mid-2018. We now report that despite confirmed gross total resection and subsequent neurologic improvement having been achieved at that time, the patient was not compliant with his prescribed adjuvant antifungal medical therapy, and for 6 months was lost to follow-up. We now report that the same patient again presented to our unit in early-2019 with recurrent granulomatous cryptococcomas, of an alarming even larger size, in the contralateral hemisphere. Fortunately, were again were able to successfully manage him surgically and have now adapted our surveillance plan to include booked follow-up magnetic resonance imaging. CONCLUSIONS:According to our review of the English literature, to our knowledge, this is the first report of recurrent granulomatous cryptococcomas occurring in the contralateral hemisphere within 6 months of surgery. The case illustrates the importance of the adjuvant antifungal medial therapy if recurrence is to be avoided.

journal_name

World Neurosurg

journal_title

World neurosurgery

authors

Kelly A,Lekgwara P,Otto D

doi

10.1016/j.wneu.2020.04.236

subject

Has Abstract

pub_date

2020-08-01 00:00:00

pages

79-88

eissn

1878-8750

issn

1878-8769

pii

S1878-8750(20)30946-3

journal_volume

140

pub_type

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