Abstract:
:Glioblastoma (GBM) is a common brain tumour in adults, which, despite multimodality treatment, has a poor median survival. Efficacy of therapy is assessed by clinical examination and magnetic resonance imaging (MRI) features. There is now a recognised subset of treated patients with imaging features that indicate "progressive disease" according to Macdonald's criteria, but subsequently, show stabilisation or resolution without a change in treatment. In these cases of "pseudoprogression", it is believed that non-tumoural causes lead to increased contrast enhancement and conventional MRI is inadequate in distinguishing this from true tumour progression. Incorrect diagnosis is important, as failure to identify pseudoprogression could lead to an inappropriate change of effective therapy. The purpose of this review is to outline the current research into radiological assessment with MRI and molecular imaging of post-treatment GBMs, specifically the differentiation between pseudoprogression and tumour progression.
journal_name
Clin Radioljournal_title
Clinical radiologyauthors
Abdulla S,Saada J,Johnson G,Jefferies S,Ajithkumar Tdoi
10.1016/j.crad.2015.06.096subject
Has Abstractpub_date
2015-11-01 00:00:00pages
1299-312issue
11eissn
0009-9260issn
1365-229Xpii
S0009-9260(15)00315-3journal_volume
70pub_type
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journal_title:Clinical radiology
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journal_title:Clinical radiology
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更新日期:2017-10-01 00:00:00
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doi:10.1016/j.crad.2004.04.021
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doi:10.1016/s0009-9260(82)80400-5
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journal_title:Clinical radiology
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doi:10.1016/s0009-9260(79)80100-2
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pub_type: 杂志文章
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pub_type: 临床试验,杂志文章,随机对照试验
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