Tumour progression or pseudoprogression? A review of post-treatment radiological appearances of glioblastoma.

Abstract:

:Glioblastoma (GBM) is a common brain tumour in adults, which, despite multimodality treatment, has a poor median survival. Efficacy of therapy is assessed by clinical examination and magnetic resonance imaging (MRI) features. There is now a recognised subset of treated patients with imaging features that indicate "progressive disease" according to Macdonald's criteria, but subsequently, show stabilisation or resolution without a change in treatment. In these cases of "pseudoprogression", it is believed that non-tumoural causes lead to increased contrast enhancement and conventional MRI is inadequate in distinguishing this from true tumour progression. Incorrect diagnosis is important, as failure to identify pseudoprogression could lead to an inappropriate change of effective therapy. The purpose of this review is to outline the current research into radiological assessment with MRI and molecular imaging of post-treatment GBMs, specifically the differentiation between pseudoprogression and tumour progression.

journal_name

Clin Radiol

journal_title

Clinical radiology

authors

Abdulla S,Saada J,Johnson G,Jefferies S,Ajithkumar T

doi

10.1016/j.crad.2015.06.096

subject

Has Abstract

pub_date

2015-11-01 00:00:00

pages

1299-312

issue

11

eissn

0009-9260

issn

1365-229X

pii

S0009-9260(15)00315-3

journal_volume

70

pub_type

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