Abstract:
PURPOSE:The purpose of this study was to examine our hypotheses that botulinum toxin A (BoTA) protect necrosis of perforator flap from perforator twisting. METHODS:Twenty-four rats were randomly divided into 2 groups. Twelve International Units of BoTA versus 1.2 mL normal saline was injected subdermally 3 days before flap elevation. In each group, bilateral before deep inferior epigastric perforator (DIEP) flaps, 5 × 3 cm in size, were created. The right and left (180 and 360 degrees of perforator twisting) DIEP flaps were separated. At 1 and 3 days postoperatively, skin above the perforator of the DIEP flaps was harvested to examine the degrees of gene expressions. Final survival percentage of flap and histology were assessed at postoperative day 5. RESULTS:The survival percentage of flap was significantly higher in the BoTA group than in the control group at both DIEP flaps after 180 and 360 degrees of perforator twisting at postoperative day 5 (95.23 ± 2.85% vs 91.00 ± 3.77%; P = 0.021 and 91.59 ± 2.87% vs 30.03 ± 6.91%; P < 0.001, respectively).Higher fibroblast density, enhanced epithelial necrosis, and inflammation were noted in the control group than in the BoTA group. In 180 degrees of perforator twisting group, BoTA may augment angiogenesis possibly via nuclear factor-κB-induced destabilization and the nuclear factor-κB/hypoxia-inducible factor 1-α/vascular endothelial growth factor pathway, whereas in the 360 degrees of perforator twisting group, the mechanistic target of rapamycin/hypoxia-inducible factor 1-α/vascular endothelial growth factor pathway may participate in BoTA-induced effective angiogenesis. CONCLUSIONS:We demonstrated that pretreatment with BoTA protects perforator flap caused by perforator at the pathological and molecular level using an experimental rat model.
journal_name
Ann Plast Surgjournal_title
Annals of plastic surgeryauthors
Kim SY,Lee SH,Lee B,Park YJ,Park JH,Lee YS,Rah DK,Park THdoi
10.1097/SAP.0000000000000563subject
Has Abstractpub_date
2016-08-01 00:00:00pages
242-8issue
2eissn
0148-7043issn
1536-3708journal_volume
77pub_type
杂志文章abstract::Since 1998, 42 hand transplants in 30 patients have been performed in countries such as France, United States, China, Austria, Malaysia, Italy, Belgium, Poland, Spain, and Germany. Now, with recent improvements in immunosuppression, the clinical applicability may expand and the ethical obstacles may soon be overcome, ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章,评审
doi:10.1097/SAP.0b013e31818d45e9
更新日期:2009-09-01 00:00:00
abstract::Surgical procedures commonly associated with parenteral sedation or general anesthesia were completed in an office operating room with local anesthesia and oral medication. Diazepam and alprazolam were used in combination to produce a relaxed state, allowing local anesthesia to be instilled. Surgery was completed succ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-200044050-00007
更新日期:2000-05-01 00:00:00
abstract:PURPOSE:The reconstruction of complicated defects with 3-dimensional deficits remains challenging. The reconstruction of these defects requires not only coverage of surface but also appropriate obliteration of dead space, and muscle-chimeric perforator flaps can be a valuable option. Here, we present our experience wit...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0b013e3182a6363c
更新日期:2015-05-01 00:00:00
abstract::Our understanding of muscle, fascia, and skin flap physiology is based largely on data obtained from rodent, rabbit, or canine models. The presence of a well-developed panniculus carnosus confounds the extrapolation of data from these animals to humans. This study attempted to define microsurgically applicable musculo...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-199805000-00005
更新日期:1998-05-01 00:00:00
abstract::Seven male patients and 8 total ears underwent composite excision for neoplasm of the auricular helix. Defect size ranged from 2.5 to 4.5 cm exceeding the conventional limit of l.5 cm for wedge excision with primary closure. An incision at the root of the helix released the superior auricular muscle and a portion of t...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0b013e3181a395fb
更新日期:2009-05-01 00:00:00
abstract:BACKGROUND:Despite the recent surge in rates of immediate breast reconstruction, there is a paucity of large multicenter studies to compare differences in morbidity after immediate versus delayed breast reconstruction. This study used the National Surgical Quality Improvement Program (NSQIP) to study the association be...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0000000000002590
更新日期:2020-11-17 00:00:00
abstract::Pitanguy conducted a series of anatomic studies on the dermocartilaginous ligament of the nose. However, information on its structure is as yet insufficient. In addition, some of the histologic findings described by Pitanguy are controversial. The present study was undertaken to clarify the anatomy of the dermocartila...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0b013e318031c1b7
更新日期:2007-10-01 00:00:00
abstract::The high number of reconstructive dilemmas brought about by more aggressive treatment of congenital malformations and burns has created the need for large quantities of donor skin for local coverage. Tissue expansion with external ports has become part of the authors' surgical armamentarium. From January 1996 to Novem...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-200044010-00003
更新日期:2000-01-01 00:00:00
abstract::Five patients each with grade IIIB or IIIC distal tibial injuries are presented. All patients were treated initially by multiple debridements and external fixation of the tibial fracture. After failure of the primary treatment, each patient underwent microsurgical free muscle transfer and bone transport of the proxima...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-199302000-00001
更新日期:1993-02-01 00:00:00
abstract::Long-term nipple projection remains the elusive ingredient for measuring the success of a nipple reconstruction. Augmentation of this projection without sacrifice of autogenous donor tissues may be achieved using a polyurethane-coated silicone gel implant affectionately and descriptively called the "gumdrop" nipple. T...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-199001000-00015
更新日期:1990-01-01 00:00:00
abstract::The first metatarsophalangeal joint area is a very difficult one to reconstruct, needing skin that is thick, sensitive, and resistant to friction. Although the medial plantar island flap was initially described to resurface heel defects, we have used this flap as a cross-foot flap to recover the first metatarsophalang...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-198805000-00012
更新日期:1988-05-01 00:00:00
abstract::A new genioplasty technique has been described and performed on 16 patients since 1995. The technique has been developed to avoid some undesired results of the current osseous genioplasty techniques and to achieve a more natural appearance in advancement genioplasty. According to the authors' technique, a rectangular ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:
更新日期:1999-08-01 00:00:00
abstract:BACKGROUND/OBJECTIVE:In this study, we evaluated the role of antitumor necrosis factor-alpha (TNF-α) therapy in the decrease of adipocyte apoptosis and weight preservation of fat grafts in the rat model. METHODS:A total of 64 rats were randomly divided into 2 groups, with 32 rats in each group. Autologous fat tissue w...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0b013e31821deb1b
更新日期:2012-05-01 00:00:00
abstract::Melanoma excision requires wide margins, leaving large defects. Surgical dogma has taught that definitive reconstruction of melanoma defects be performed after permanent pathology results, with skin grafts favored. However, this results in an open wound and the need for a second operation. The advantages of immediate ...
journal_title:Annals of plastic surgery
pub_type: 临床试验,杂志文章
doi:10.1097/SAP.0000000000000166
更新日期:2014-05-01 00:00:00
abstract:BACKGROUND:The use of internal mammary perforators (IMPs) as recipient vessels in autologous free flap breast reconstruction has many additional benefits compared with the internal mammary or thoracodorsal vessels. Our goals were to analyze the characteristics of these vessels and to evaluate the reliability of using t...
journal_title:Annals of plastic surgery
pub_type: 临床试验,杂志文章
doi:10.1097/SAP.0b013e318270704b
更新日期:2014-08-01 00:00:00
abstract:BACKGROUND:Although aging changes of the female perioral region and aesthetic procedures for perioral rejuvenation are described in literature, specific data for the male population are lacking. This study aims to evaluate perioral aging process in the male population to compare quality and quantity of the observed cha...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0000000000000931
更新日期:2017-03-01 00:00:00
abstract::A subjective description of a technique of immediate reconstruction of cutaneous defects due to laceration is presented. Extension of the use and range of the Z-plasty is emphasized and its benefits and limitations are discussed. The reconstructive surgeon is challenged to consider wider and more frequent use of these...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-197809000-00003
更新日期:1978-09-01 00:00:00
abstract::Perforator flaps are widely used in reconstructive surgery, but little is known about the hemodynamic changes within these flaps. Recently, the blood velocity in the perforator artery was shown to be higher than that at the source vessel. This study was carried out to demonstrate the effect of this increased velocity ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0b013e318145be31
更新日期:2008-06-01 00:00:00
abstract::Although various methods for reconstruction of burn alopecia have been described in case reports and small case series, a comprehensive comparison of these methods has not been performed. The purpose of this study was to assess the appropriateness of the clinical indications for the various reconstructive methods for ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0b013e3181d2487a
更新日期:2010-09-01 00:00:00
abstract::Noma is primarily affecting children in underprivileged countries and results in disfiguring facial defects, loss of mandibular movement, and subsequent social disintegration. Plastic surgery in West Africa traditionally uses pedicled flaps. In large, complex, or central facial defects, though, pedicled flaps are apt ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/01.sap.0000165688.50780.e9
更新日期:2005-08-01 00:00:00
abstract::We present 8 cases of microvascular reconstruction of the pharynx and cervical esophagus using 5 free ileal transfers and 3 radial forearm flaps. One of the skin flaps underwent a delay procedure a month before transfer. All flaps survived, though there were 2 salivary fistulas that healed spontaneously. ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-199311000-00010
更新日期:1993-11-01 00:00:00
abstract:PURPOSE:This report summarizes our experience in the management of extratemporal facial paralysis with a variety of reconstructive techniques and explores those parameters which are considered to be useful in achieving better outcomes. METHODS:In all, 56 patients with extratemporal facial paralysis were studied. All t...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0b013e3182352221
更新日期:2013-02-01 00:00:00
abstract::A case of a closed rupture of a single slip of flexor digitorum superficialis to the little finger is described. Closed rupture injuries of the flexor digitorum profundus tendon are quite common, but closed injuries to the superficialis tendon have been rarely reported. A single slip avulsion rupture of this tendon wo...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-200110000-00012
更新日期:2001-10-01 00:00:00
abstract::Free flaps are increasingly being chosen to solve complex reconstruction problems. We describe a fascial sleeve approach to elevation of the donor flap which increases its safety and reliability. We report examples in which resultant revascularization of the recipient site causes the free flap to be irreplaceable for ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-198212000-00006
更新日期:1982-12-01 00:00:00
abstract::A new surgical technique for upper lip augmentation is presented. In this technique, 2 vertically parallel V-shaped incisions placed in a "V in V" fashion are used. Remarkable augmentation of the lip is provided by V-to-Y closure of the incisions. Over 7 years, this new technique, namely, V-Y in V-Y procedure, was use...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/01.sap.0000205774.40210.58
更新日期:2006-06-01 00:00:00
abstract::One of our patients had been recovering from prolonged illness for about eight months following extensive deep burns of the lower limbs, along with other complications, when he had a sudden attack of acute dyspnea with orthopnea. The cause of this condition was diagnosed as secondary hypodynamic cardiomyopathy. We fou...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-198710000-00014
更新日期:1987-10-01 00:00:00
abstract:BACKGROUND:Whether postoperative care in the intensive care unit (ICU) is a necessity for patients undergoing head and neck free flap reconstruction remains debatable. In August 2012, our institute initiated a policy to care for these patients in the ICU, opposed to the previous policy of care in the ward. Thus, we use...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0000000000001301
更新日期:2018-02-01 00:00:00
abstract::Volume resuscitation of patients with high-voltage electrical injuries (>1000 V) is a more complex challenge than standard burn resuscitation. High voltages penetrate deep tissues. These deep injuries are not accounted for in resuscitation formulae dependent on percentage of cutaneous burn. Myonecrosis occurring from ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章,评审
doi:10.1097/SAP.0000000000001374
更新日期:2018-03-01 00:00:00
abstract::In an experiment using a continuous tissue pH monitoring system, selective occlusion of the vessels supplying lower abdominal island flaps in Sprague-Dawley rats resulted in predictable tissue pH changes. Arterial occlusion resulted in a rapid fall in pH. In all three experimental groups, the steepest rate of pH drop ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-198310000-00013
更新日期:1983-10-01 00:00:00
abstract::From 1979 to 1983, 14 patients were treated at the University of Maryland Hospital for injuries sustained as a result of the injection of crushed pentazocine tablets partially dissolved in water into the arterial system of the upper extremity. Eight patients received intraarterial reserpine within 15 hours of the inju...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-198701000-00010
更新日期:1987-01-01 00:00:00