Abstract:
BACKGROUND/OBJECTIVE:In this study, we evaluated the role of antitumor necrosis factor-alpha (TNF-α) therapy in the decrease of adipocyte apoptosis and weight preservation of fat grafts in the rat model. METHODS:A total of 64 rats were randomly divided into 2 groups, with 32 rats in each group. Autologous fat tissue was grafted subcutaneously on the back of each rat. For the experimental group, antirat TNF-α monoclonal antibody was injected into the fat grafts during operation. No treatment was given to the tissue in the control group. Eight rats in each group were killed respectively, at days 7, 14, 30, and 60 postoperatively and sampled for assessments of weight preservation, gene expression of TNF-α, histology, and adipocyte apoptosis. RESULTS:There were no significant differences in the weight of fat tissues between the control group and the experimental group at days 7, 14, and 30 postoperatively (P > 0.05). However, the preservation ratio of the tissue was 65.36% ± 14.98% in the antirat TNF-α antibody-treated group when compared with the weight at transplantation, which was significantly higher than the control group (44.63% ± 10.39%) 60 days after the operation (P < 0.05). The numbers of apoptotic cells in the control group were 15.6 ± 3.17, 24.6 ± 4.34, 22.8 ± 2.42, and 27 ± 3.83 per field at different postoperative intervals. However, the numbers of apoptotic cells in the tissues treated with TNF-α antibody were significantly lower than that in the control group, which was 1 ± 0.63, 4 ± 1.41, 6 ± 2.08, and 7.2 ± 2.82 per field (P < 0.05). Gene expression showed that the expression of TNF-α was lower in the experimental group than the control group at days 7 and 14 postoperatively (P < 0.05). CONCLUSION:The results indicate that antirat TNF-α monoclonal antibody can preserve the quality of the transplanted fat tissue.
journal_name
Ann Plast Surgjournal_title
Annals of plastic surgeryauthors
Yang M,Zhang F,Sailes FC,Zhang EW,Lin S,Das SKdoi
10.1097/SAP.0b013e31821deb1bsubject
Has Abstractpub_date
2012-05-01 00:00:00pages
531-5issue
5eissn
0148-7043issn
1536-3708journal_volume
68pub_type
杂志文章abstract:INTRODUCTION:Full-thickness soft tissue defects of the back remain challenging clinical problems for reconstructive surgeons. Among a vast variety of local flap options, perforator-based local flaps gain increasing popularity lately. Because mostly heterogeneous patient cohort comparison of different perforator flaps i...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0000000000002439
更新日期:2021-01-01 00:00:00
abstract:PURPOSE:Limb salvage in bone sarcomas requires resection and joint and soft-tissue reconstruction. Suboptimal coverage can lead to prosthesis infection, subsequent hardware exposure, or loss with eventual amputation. In the pediatric sarcoma population, it is essential to not only have viable soft-tissue coverage but o...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0b013e3182223d5b
更新日期:2012-11-01 00:00:00
abstract::According to most of the literature, sutures for microarterial repair must include the intima to prevent an "intimal flap" and occlusion of the anastomosis. Some authors have said that vessel diameter affects patency rate. This study was designed to evaluate these two statements. The femoral arteries (about 1.0 mm in ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-197903000-00010
更新日期:1979-03-01 00:00:00
abstract::Superficial temporal artery (STA) aneurysms are a medical rarity. There are less than 200 patients reported in the literature. The majority of cases are of traumatic etiology and occur in young men. The senior authors reported a case of STA aneurysm in 1978. We now review the literature and report on three additional ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章,评审
doi:10.1097/00000637-199806000-00018
更新日期:1998-06-01 00:00:00
abstract::Although various techniques have been reported to correct blepharoptosis, undercorrection is still a commonly occurring complication and needs further revision procedure. Scar formation and distorted anatomy make reoperation more difficult than the primary surgery. However, tarsus is usually fully maintained in the fi...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0000000000000223
更新日期:2015-12-01 00:00:00
abstract::Nitric oxide (NO), identified as the mediator of endothelium-dependent relaxation of vascular smooth muscle, is known to cause a number of inflammatory conditions, especially in ischemia/reperfusion injury. This experimental study, using a rabbit epigastric island flap, was designed to investigate whether skin flap is...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-199712000-00009
更新日期:1997-12-01 00:00:00
abstract::Immediate breast reconstruction with expander implants is a safe, simple procedure that allows for a rapid physical and emotional postmastectomy recovery. When complications occur, the patient may be left with a prolonged reconstructive course. Such complications may result from thin mastectomy flaps and resulting mar...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/01.sap.0000154855.89547.ee
更新日期:2005-04-01 00:00:00
abstract::This study reviewed the fate of titanium plates used to correct maxillofacial trauma in 76 patients to define risk factors for plate removal. Medical records of 76 consecutive patients at a single institution, over a 10-year period, were retrospectively reviewed. Variables included age, sex, trauma type, diagnosis, fr...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/01.sap.0000183802.38116.37
更新日期:2005-12-01 00:00:00
abstract::A variety of surgical techniques have been described for medial canthal tendon reattachment. They generally require technical skill and prolonged operating time. We have applied a new device, the Mitek Anchor System, in reattaching the medial canthal tendon to the medial orbital wall in 3 patients, and got excellent t...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-199702000-00005
更新日期:1997-02-01 00:00:00
abstract::This paper presents 4 consecutive cases using negative-pressure dressings (VAC) to bolster skin grafts in male genital reconstruction. In this series reconstruction followed 1 case of tumor ablation and 3 cases of debridement of abscesses or Fornier's gangrene. The VAC was applied circumferentially to the penis to sec...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/01.sap.0000143606.39693.3f
更新日期:2005-02-01 00:00:00
abstract::Twenty-five feet (18 patients) plus 2 traumatically amputated feet were used for angiographic analysis of the first metatarsal arteries. The author classified the first (dorsal and plantar) metatarsal arteries into three types: the first dorsal metatarsal artery, dominant type (seen in 17 feet), the first plantar meta...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-198107000-00002
更新日期:1981-07-01 00:00:00
abstract::Subgalea-periosteal flaps were successfully used in a turnover pattern to reconstruct two scalp defects with exposed calvaria caused by tumor ablation. A copious vascular network of the subgaleal fascia in the base and its attached lateral territories provide adequate blood inflow for the turnover flap. The periosteum...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:
更新日期:1993-03-01 00:00:00
abstract::We report 2 cases of patients with thumb polydactyly that were difficult to classify into either Wassel type VI with a remarkable hypoplastic metacarpal or Wassel type VII (triphalangeal thumb). The radial digit was functional but hypoplastic, and the ulnar digit presented a dominant appearance but no active motion. T...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0b013e31821b6ced
更新日期:2013-01-01 00:00:00
abstract::There have been numerous techniques and refinements for nipple-areola reconstruction described that have required the use of distant donor sites. A further modification of the skate flap is described, whereby the entire reconstruction can be performed on site, thus avoiding a second scar and any subsequent morbidity. ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-199203000-00014
更新日期:1992-03-01 00:00:00
abstract:BACKGROUND:: Penile reconstruction has always been a challenging problem for plastic surgeons while facing patients with severe congenital deformities and gender dysphoria and those who have suffered penile loss because of trauma, self-amputation, malignancy, and so on. Since 1936, when Bogoras first constructed a tota...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/01.sap.0000253745.07940.da
更新日期:2007-07-01 00:00:00
abstract::Surgeons at our center previously reported a case of a 2-month-old infant who underwent closure of an infected sternal wound following open cardiac surgery with debridement followed by closure with bilateral pectoralis muscle flaps and a unilateral rectus abdominis muscle flap. The success of the procedure has spawned...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/01.sap.0000183681.56595.0a
更新日期:2005-11-01 00:00:00
abstract::One of the surgical goals of phalloplasty is to obtain sufficient rigidity for sexual penetration. This is also important for patients with erectile dysfunction. Different kinds of techniques have described phalloplasty and obtaining rigidity in patients with erectile dysfunction, but there is no good substitute for t...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/01.SAP.0000044142.17243.8C
更新日期:2003-05-01 00:00:00
abstract::There are a variety of traditional treatments for the removal of unwanted hair. Recently, lasers have been developed to remove hair. The long-pulsed ruby laser uses light at a wavelength of 694 nm with a 3-msec pulse to destroy hair. Seventy-two patients were treated with this laser from one to four times in a variety...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-199807000-00001
更新日期:1998-07-01 00:00:00
abstract::Vascularized muscle flaps for treatment of mediastinitis and sternal wound dehiscence have become standard treatment practice, but triple-muscle flap reconstruction is reserved for the more complex wounds. The incisional approach for reoperation in such patients is controversial. We report an extremely ill infant, bor...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-199805000-00015
更新日期:1998-05-01 00:00:00
abstract:ABSTRACT:Repair for the soft tissue defects of hand has been a major challenge of hand or reconstructive surgery. A lot of flaps are used, free or pedicle flap, but there are no comprehensive description of these flaps. In this article, we retrospectively reviewed the repair technique of the fingertip defect, palmar or...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0000000000002645
更新日期:2020-12-15 00:00:00
abstract::Thirteen breast reconstructions in 11 patients, averaging 58 years of age, underwent mastectomies. The technique uses a saline implant either totally or partially covered with a human acellular dermal matrix. The mean postoperative follow-up time was 14 months. Ninety percent of the patients were considered high risk;...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/01.sap.0000185460.31188.c1
更新日期:2006-01-01 00:00:00
abstract::Osteroradionecrosis of the mandible is one of the most serious complications of radiotherapy in head and neck cancer. Once osteoradionecrosis of the mandible has been established, conservative therapy is often useless. Two cases of asynchronous bilateral osteoradionecrosis of the mandible are presented. In both cases,...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0b013e318228e396
更新日期:2012-09-01 00:00:00
abstract::This study was performed to determine the degree of shrinkage over time in nipple projection after reconstruction. Nipple-areolar reconstruction was performed using the modified Anton-Hartrampf technique, and pigmentation was achieved with tattooing. This study looked at 28 consecutive patients with nipple reconstruct...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-199911000-00001
更新日期:1999-11-01 00:00:00
abstract::From an anatomical standpoint, the support of the inferior two thirds of the nose is ensured by the cartilaginous septum. Usually, the reconstruction of total loss of the quadrangular cartilage is performed with some success by means of camouflage procedures such as L-shaped struts or cantilever grafts. In this articl...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-199506000-00010
更新日期:1995-06-01 00:00:00
abstract::Transverse rectus abdominis musculocutaneous (TRAM) breast reconstruction in patients with advanced breast cancer is controversial. Management of these patients is often complex and consists of surgical extirpation, postoperative radiation, chemotherapy, and in some cases bone marrow transplantation. Few studies have ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/01.SAP.0000069075.27321.BC
更新日期:2003-06-01 00:00:00
abstract:INTRODUCTION:Proper wound care along with the use of skin grafts over deep burn wounds has been the standard treatment. However, the goal in burn wound care has shifted from achieving a satisfactory survival rate to improving long-term form and function of the healed wound, which is sometimes hindered by scar contractu...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0000000000002676
更新日期:2021-02-01 00:00:00
abstract::Breast augmentation is one of the leading esthetic surgeries, enjoying high satisfaction rates. Pain, nausea, and vomiting are frequent shortcomings of the immediate postoperative period. The aim of this study was to compare breast augmentation from the anesthetic point of view: general anesthesia (GA) versus monitore...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0b013e31815bfe98
更新日期:2008-09-01 00:00:00
abstract::The use of a Keith needle is described to secure a cartilage graft during rhinoplasty. ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:
更新日期:1980-01-01 00:00:00
abstract::The purpose of this study was to measure the biomechanical performance for commercially available microsutures, nylon polypropylene, polyester, and polyglactin 910. The biomechanical performance was determined by reproducible, biomechanical parameters that included stiffness, elasticity, resistance to creep, secure kn...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-199404000-00014
更新日期:1994-04-01 00:00:00
abstract::We present a case of a nail defect, which was reconstructed by free composite nail combined with the palmar pocket method without vascular anastomoses. A 40-year-old man lost his nail of the right middle finger by trauma 1 year ago. A total nail composite graft, composed of germinal and sterile matrices, and proximal ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/01.sap.0000164731.99795.fe
更新日期:2005-06-01 00:00:00