Abstract:
PURPOSE:To document a case of a biphenotypic sinonasal sarcoma that impinged on the orbit via a tumor-induced mucocele and review the previous literature devoted to this condition. METHODS:A clinicopathologic case report with detailed histopathologic, immunohistochemical, and radiological studies with tabulations of previously reported cases and immunohistochemical stains for ruling out mimicking lesions. RESULTS:A biphenotypic sinonasal sarcoma arose from the ethmoid sinus in a middle-aged man. The tumor induced a mucocele that bowed the medial orbital lamina papyracea into the orbit and caused diplopia and mild proptosis. The biopsy's dual positivity for S100 and smooth muscle actin together with positive paired box 3 immunohistochemical staining established the diagnosis of biphenotypic sinonasal sarcoma. CONCLUSION:Biphenotypic sinonasal sarcoma, which can involve the orbit in 25% of cases, is a rare head and neck malignancy that has only recently been described. Biphenotypic sinonasal sarcoma is a low-grade, locally aggressive, nonmetastasizing sarcoma displaying both neural and muscle differentiation. It is further characterized by rearrangements of the PAX3 gene with multiple fusion partners, most commonly MAML3 (Mastermind like transcriptional coactivator 3). It occurs predominantly in middle-aged women and exclusively in the sinonasal tract. However, it can spread throughout the central facial structures to invade the brain if not detected early. Ophthalmologists should be aware of this new entity to avoid delays in diagnosis and treatment. The previous literature devoted to this condition was reviewed and analyzed for clinical, radiological, histopathological, and immunohistochemical features. In circumstances where molecular testing is not available, paired box 3 immunohistochemical staining can be used as an alternative diagnostic marker. The current case is most unusual because the orbital findings were induced by a mucocele caused by the tumor that obstructed the sinus ostium. This produced diplopia without direct tumor invasion into the orbital fat.
journal_name
Ophthalmic Plast Reconstr Surgjournal_title
Ophthalmic plastic and reconstructive surgeryauthors
Hanbazazh M,Jakobiec FA,Curtin HD,Lefebvre DRdoi
10.1097/IOP.0000000000001839subject
Has Abstractpub_date
2020-09-25 00:00:00eissn
0740-9303issn
1537-2677pub_type
杂志文章abstract:PURPOSE:To assess the efficacy of a comprehensive technique for correction of severe punctal and medial lower eyelid ectropion and lower eyelid retraction associated with medial canthal ligament (MCL) laxity. METHODS:A comprehensive technique that plicates the anterior and posterior crura of the MCL was performed on 8...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章
doi:10.1097/IOP.0b013e3181469e3c
更新日期:2007-09-01 00:00:00
abstract::The implantation of an orbital hydroxyapatite implant was complicated by conjunctival dehiscence, cutaneous fistula formation, and infection with Staphylococcus aureus. Pathologic examination of the sphere 2 years after its implantation revealed reduction in the size of the implant, peripheral lamellar bone formation ...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章
doi:10.1097/00002341-199606000-00008
更新日期:1996-06-01 00:00:00
abstract:PURPOSE:The authors report and evaluate their experience with an individualized approach to orbital exenteration. METHODS:Retrospective chart review was performed on a consecutive series of 25 orbital exenteration patients at a tertiary care center. The cases were classified into two groups for the retrospective analy...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章
doi:10.1097/01.iop.0000066699.53489.88
更新日期:2003-05-01 00:00:00
abstract:PURPOSE:Platinum chains are thinner than gold weights (GWs) and may confer a better eyelid curvature profile with reduced visibility. Outcomes compared eyelid measurements, cosmesis, and complications. METHODS:Forty-two primary GW and 17 primary platinum chain insertions were identified and subsequently matched for la...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章,随机对照试验
doi:10.1097/IOP.0b013e3182467bf7
更新日期:2012-05-01 00:00:00
abstract::Fifteen patients and 28 eyes with measurable eyebrow ptosis underwent standard upper eyelid blepharoplasty with or without sub-brow fat excision. The patients were educated about the status of their eyebrow position and the effects of either direct or indirect methods of brow elevation. The patients either refused or ...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章
doi:10.1097/00002341-199209000-00009
更新日期:1992-01-01 00:00:00
abstract:PURPOSE:Congenital anophthalmia and postenucleation socket contracture are difficult conditions that require serial socket expansion with the use of hydrogel expanders and custom-made conformers along with temporary tarsorrhaphy. METHODS:The authors undertook a part prospective case review of all children undergoing t...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章
doi:10.1097/IOP.0000000000000011
更新日期:2014-01-01 00:00:00
abstract:PURPOSE:The risk of ophthalmic and retinal artery occlusions following facial and periorbital steroid injection has not been explored. This systematic review examines the prevalence, risk factors, and treatment outcomes of steroid-induced vision losses. METHODS:A literature search in Evidence Based Medicine Reviews, M...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章
doi:10.1097/IOP.0000000000001910
更新日期:2021-01-19 00:00:00
abstract:PURPOSE:To review the clinical features and management of patients with orbital roof fractures. METHODS:Non-comparative, retrospective case review of 21 patients presenting with orbital roof fractures. RESULTS:The orbital roof fractures in our series resulted from motor vehicle accidents, blunt trauma, head injuries,...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章
doi:10.1097/01.IOP.0000083646.20672.6B
更新日期:2003-09-01 00:00:00
abstract::The authors describe a 9-year-old female who presented with swelling, proptosis, and tenderness of the right upper eyelid and MRI imaging demonstrating right lacrimal gland enlargement. After failing treatment with corticosteroids, the patient underwent a biopsy that was consistent with IgG4-related orbital disease. S...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章
doi:10.1097/IOP.0000000000000959
更新日期:2018-01-01 00:00:00
abstract::There are many reviews of pediatric orbital tumors in the literature. Most of the series originated from the tumor registries of large pathology referral centers, whereas others are from large medical institutions and pediatric hospitals. The distribution of types of tumors reported in each series are unavoidably bias...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章
doi:10.1097/00002341-198903000-00002
更新日期:1989-01-01 00:00:00
abstract::We report a case of a man who had undergone gold eyelid loading for lagophthalmos 22 years earlier. During examination for a complaint of foreign body sensation in the operated eye, the gold weight was found under the palpebral conjunctiva. Although extrusion of a gold weight through the skin anteriorly is well recogn...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章
doi:10.1097/01.IOP.0000087032.75134.77
更新日期:2003-09-01 00:00:00
abstract::A total of 145 patients with orbital dermoid cysts examined at the Orbital Clinic, Institute of Ophthalmology, School of Medicine, University of Naples "Federico II" over a period of 16 years were reviewed. The orbital cysts were classified as exophytic and endophytic, according to their site of attachment in relation...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章
doi:10.1097/00002341-199509000-00005
更新日期:1995-09-01 00:00:00
abstract::Orbital intraosseous hemangiomas are rare entities, with only 15 previously reported. We review these and present our own. They are benign, vascular tumors, typically found in the frontal, ethmoid, or zygomatic bones. They tend to present in the 4th or 5th decades as a mildly painful orbital rim mass. Ocular findings ...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章,评审
doi:10.1097/00002341-198912000-00004
更新日期:1989-01-01 00:00:00
abstract:PURPOSE:To examine the positional relationship between the ethmoidal foramina and the frontoethmoidal suture. METHODS:Eighty-four orbits of 42 Japanese cadavers (24 male and 18 female cadavers; average age at death, 81.0 years; range, 61-101 years), fixed in 10% buffered formalin, were used for investigation. The most...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章
doi:10.1097/IOP.0b013e318222eb82
更新日期:2011-11-01 00:00:00
abstract::Gold hypersensitivity is a cause of periorbital dermatitis that often presents as a diagnostic challenge for many ophthalmologists. Six female patients are described as presenting with isolated bilateral periorbital dermatitis. Main symptoms included itching (3/6), eyelid redness (3/6), and drooping eyelids (3/6) for ...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章
doi:10.1097/IOP.0000000000000783
更新日期:2017-07-01 00:00:00
abstract::A 9-month-old infant presented with orbital cellulitis and recent discharge from a hair-bearing pit above the eyebrow. Orbital imaging demonstrated a tubular lesion and sinus tract extending from a hypoplastic sphenoid wing, through the lateral orbit, to the skin surface. Complete excision of the dermoid cyst and sinu...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章
doi:10.1097/01.iop.0000144789.04263.19
更新日期:2004-11-01 00:00:00
abstract:PURPOSE:To describe an innovative technique of lateral canthal tendon (LCT) anchoring to the lateral orbital rim on its inner aspect using a "lasso" technique, in order to provide the ideal vector. METHODS:A retrospective case review of seven patients (n = 7), performed from 2009 to 2013 at our institution by the seni...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章
doi:10.1097/IOP.0b013e3182a22ab8
更新日期:2014-03-01 00:00:00
abstract:PURPOSE:To describe the change in upper eyelid position in a self-reportedly normal population after the administration of topical 0.5% apraclonidine in each eye. METHODS:One hundred self-reportedly normal subjects received a 1-time administration of topical 0.5% apraclonidine in each eye. Digital photographs were tak...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章
doi:10.1097/IOP.0000000000000843
更新日期:2018-01-01 00:00:00
abstract:INTRODUCTION:Many reports have suggested that upper eyelid position and brow height can be interdependent; however, the relation is not universally observed. This study aims to understand the prevalence of this phenomenon and examine the utility of phenylephrine testing in predicting brow height change after surgery. ...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章
doi:10.1097/IOP.0000000000000458
更新日期:2016-05-01 00:00:00
abstract:PURPOSE:To describe current indications, methods, and outcomes of sentinel lymph node (SLN) biopsy for eyelid and conjunctival tumors. METHODS:Review of experience to date and relevant articles published in PubMed in English. RESULTS:The use of SLN biopsy for conjunctival and eyelid tumors has evolved greatly in the ...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章,评审
doi:10.1097/IOP.0b013e31827472c5
更新日期:2013-01-01 00:00:00
abstract:PURPOSE:To demonstrate the histopathologic characteristics of different types of lacrimal drainage system concretions with clinical correlations. METHODS:Thirty lacrimal drainage system concretions submitted to the Cogan Eye Pathology Laboratory at the Massachusetts Eye and Ear Infirmary over a 2-year period were revi...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章
doi:10.1097/IOP.0b013e31824c88a6
更新日期:2012-03-01 00:00:00
abstract:PURPOSE:To describe a technique for sentinel node mapping and biopsy in patients with orbital or adnexal tumors. METHODS:Five patients with orbital and adnexal tumors were studied. Two patients had malignant eyelid melanomas (one of the skin and one of the conjunctiva), one with orbital invasion. Two patients had seba...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章
doi:10.1097/00002341-200109000-00008
更新日期:2001-09-01 00:00:00
abstract:PURPOSE:Soft tissue dermal fillers, both temporary and permanent, are used frequently in facial rejuvenation. As the use of fillers increases, ischemic complications including skin necrosis are becoming more prevalent. In the literature, topical nitroglycerin paste has been recommended in the early treatment of patient...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章
doi:10.1097/IOP.0000000000000446
更新日期:2016-03-01 00:00:00
abstract::A 15-month-old boy with left congenital proptosis presented to the emergency department with melena. Upper GI endoscopy and magnetic resonance angiography revealed vascular lesions, consistent with gastrointestinal tract manifestations of blue rubber bleb nevus syndrome. MRI revealed vascular malformations in both orb...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章
doi:10.1097/IOP.0000000000000692
更新日期:2017-05-01 00:00:00
abstract::Acquired eyelash hypertrichosis is associated with medications, systemic diseases, and ocular inflammation. The authors present a study showing that eyelash length is significantly longer following enucleation and evisceration surgery compared with the contralateral side. This may be related to factors involved in pos...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章
doi:10.1097/IOP.0b013e3181b8c5ef
更新日期:2010-01-01 00:00:00
abstract::Chronic chalazia that predominantly involve the anterior eyelid lamellae are most easily approached through a transcutaneous incision. We describe the use of an eyelid crease incision for chalazia of the upper lid as an alternative to incision directly over the lesion. The technique has been used successfully in 16 pa...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章
doi:10.1097/00002341-198903000-00012
更新日期:1989-01-01 00:00:00
abstract:PURPOSE:To assess for alterations in the microscopic anatomy that occur as a result of the Müller muscle-conjunctival resection (MMCR) ptosis procedure and to better understand the mechanisms by which MMCR elevates the eyelid. METHODS:Sixteen orbits from 8 fresh frozen Caucasian cadaver heads, ranging from 38 to 100 y...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章
doi:10.1097/IOP.0b013e3181cb79a2
更新日期:2010-09-01 00:00:00
abstract::Alveolar soft-part sarcoma (ASPS) is a translocation-associated sarcoma that occurs most commonly in the lower extremities and rarely in orbit. Only 34 orbital cases have been reported in the literature, and it is often misdiagnosed due to its rare occurrence and nonspecific clinical findings. The optimal treatment re...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章,评审
doi:10.1097/IOP.0b013e318281ecb9
更新日期:2013-11-01 00:00:00
abstract:PURPOSE:To report 5 patients with a black material accumulating in the conjunctiva around the titanium peg and sleeve systems. METHODS:Retrospective small case series. The clinical features of 5 patients were reviewed. Histopathologic analysis was performed on specimens from 3 patients. Neutron activation analysis was...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章
doi:10.1097/00002341-200211000-00012
更新日期:2002-11-01 00:00:00
abstract::We present the case of a 59-year-old woman whose silicone punctal plugs migrated distally causing lacrimal obstruction. The plugs were removed from the lacrimal sac during endoscopic endonasal dacrocystorhinostomy and is illustrated by endoscopic photographs and videos taken at the time of surgery. This case highlight...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章
doi:10.1097/IOP.0b013e31825ca8b6
更新日期:2013-01-01 00:00:00