Abstract:
:BACKGROUND: Frequent migraine headaches are disabling and aeromedically disqualifying. Four new monoclonal antibody medications, targeting calcitonin gene-related peptide (CGRP), have been approved by the U.S. Food and Drug Administration (FDA) since 2018, with more expected in the coming years. These medications present new alternatives for the treatment of migraine unresponsive to other therapeutic and prophylactic agents.CASE REPORT: We present a case of a 45-yr-old commercial pilot who presented with migraine headaches increasing in frequency to 1315 per month in spite of the use of propranolol for prophylaxis and sumatriptan for abortive treatment of the headaches. Upon presentation, he was not flying due to his frequent headaches and he was started on monthly subcutaneous injections of fremanezumab. Following his second injection, his headaches stopped entirely, and he has continued on the medication and not experienced another migraine headache. He underwent an aeromedical neurology evaluation and consideration for Authorization of Special Issuance of Medical Certificate, which was granted by the Federal Aviation Administration (FAA).DISCUSSION: This is the first case to our knowledge of the successful use of an anti-CGRP monoclonal antibody medication in an active pilot. The pilot appears to be a super responder to the medication, having achieved complete remission of a nearly life-long condition. Though only a small portion of treated individuals will see this sort of response, these medications represent an effective additional option for migraine prophylaxis in the pilot population.Garber MA, Sirven JI, Roth RS, Hemphill JM. Migraine prophylaxis using novel monoclonal antibody injections in a commercial pilot. Aerosp Med Hum Perform. 2020; 91(10):824825.
journal_name
Aerosp Med Hum Performjournal_title
Aerospace medicine and human performanceauthors
Garber MA,Sirven JI,Roth RS,Hemphill JMdoi
10.3357/AMHP.5688.2020subject
Has Abstractpub_date
2020-10-01 00:00:00pages
824-825issue
10eissn
2375-6314issn
2375-6322journal_volume
91pub_type
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journal_title:Aerospace medicine and human performance
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doi:10.3357/AMHP.4312.2015
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abstract::BACKGROUND: Emergency helicopter landing at sea is dangerous. Specialized training, known as helicopter underwater escape training (HUET), prepares occupants to quickly exit the helicopter, which often inverts and sinks. In most jurisdictions, helicopter occupants are equipped with a helicopter underwater egress breat...
journal_title:Aerospace medicine and human performance
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journal_title:Aerospace medicine and human performance
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journal_title:Aerospace medicine and human performance
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doi:10.3357/AMHP.4630.2016
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journal_title:Aerospace medicine and human performance
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doi:10.3357/AMHP.EC02.2015
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journal_title:Aerospace medicine and human performance
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journal_title:Aerospace medicine and human performance
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journal_title:Aerospace medicine and human performance
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doi:10.3357/AMHP.4257.2015
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journal_title:Aerospace medicine and human performance
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doi:10.3357/AMHP.4510.2016
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journal_title:Aerospace medicine and human performance
pub_type: 杂志文章
doi:10.3357/AMHP.4993.2018
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journal_title:Aerospace medicine and human performance
pub_type: 杂志文章
doi:10.3357/AMHP.EC12.2015
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journal_title:Aerospace medicine and human performance
pub_type: 杂志文章
doi:10.3357/AMHP.5425.2020
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journal_title:Aerospace medicine and human performance
pub_type: 杂志文章,随机对照试验
doi:10.3357/AMHP.4139.2015
更新日期:2015-04-01 00:00:00
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journal_title:Aerospace medicine and human performance
pub_type: 杂志文章,随机对照试验
doi:10.3357/AMHP.3932.2015
更新日期:2015-01-01 00:00:00
abstract::INTRODUCTION: In-flight medical emergencies (IFMEs) average 1 of every 604 flights and are expected to increase as the population ages and air travel increases. Flight diversions, or the rerouting of a flight to an alternate destination, occur in 2 to 13% of IFME cases, but may or may not be necessary as determined af...
journal_title:Aerospace medicine and human performance
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journal_title:Aerospace medicine and human performance
pub_type: 杂志文章
doi:10.3357/AMHP.4581.2016
更新日期:2016-09-01 00:00:00
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journal_title:Aerospace medicine and human performance
pub_type: 杂志文章
doi:10.3357/AMHP.4450.2017
更新日期:2017-08-01 00:00:00
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journal_title:Aerospace medicine and human performance
pub_type: 杂志文章
doi:10.3357/AMHP.5429.2019
更新日期:2019-11-01 00:00:00
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journal_title:Aerospace medicine and human performance
pub_type: 杂志文章
doi:10.3357/AMHP.5416.2019
更新日期:2019-10-01 00:00:00
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journal_title:Aerospace medicine and human performance
pub_type: 杂志文章
doi:10.3357/AMHP.5008.2018
更新日期:2018-06-01 00:00:00
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journal_title:Aerospace medicine and human performance
pub_type: 杂志文章
doi:10.3357/AMHP.5390.2020
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journal_title:Aerospace medicine and human performance
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doi:10.3357/AMHP.4041.2015
更新日期:2015-02-01 00:00:00
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journal_title:Aerospace medicine and human performance
pub_type: 杂志文章
doi:10.3357/AMHP.5229.2019
更新日期:2019-04-01 00:00:00
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journal_title:Aerospace medicine and human performance
pub_type: 杂志文章,评审
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更新日期:2018-08-01 00:00:00
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journal_title:Aerospace medicine and human performance
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doi:10.3357/AMHP.4449.2016
更新日期:2016-02-01 00:00:00
abstract::INTRODUCTION: The Statement of Demonstrated Ability (SODA) is a type of U.S. aeromedical waiver used for disqualifying conditions that are not expected to change. About 21,000 (2%) U.S. pilots possess a SODA waiver.METHODS: We matched all pilot medical exams from the FAA's medical certification database from 2002 thro...
journal_title:Aerospace medicine and human performance
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更新日期:2019-12-01 00:00:00
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journal_title:Aerospace medicine and human performance
pub_type: 杂志文章,随机对照试验
doi:10.3357/AMHP.4768.2017
更新日期:2017-07-01 00:00:00
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journal_title:Aerospace medicine and human performance
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journal_title:Aerospace medicine and human performance
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