Abstract:
Objective:The study was performed to investigate the association of hypertension in pregnancy with prostasin gene polymorphism in Pakistani females. Methods:This case-control study was performed at University of Karachi, Pakistan from April 2018 to May 2019. A total of 160 females, including 90 hypertensives and 70 healthy pregnant females, were recruited by purposive sampling after obtaining informed written consent. Genotyping was performed by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP). Results:The frequencies of the TC and CC genotypes were higher in hypertensive pregnant females compared to healthy controls. A significant difference was evident for CC (P=0.012) genotype; however, no significant difference was observed for TC (P=0.49) and TT genotypes (P=0.06) between control and hypertensive groups. The adjusted odds ratio for CC genotype was 6.2 (P=0.025) and 1.48 (P=0.44) for TC genotype compared to the TT genotype. There was a significantly higher prevalence of the C allele of the prostasin gene at rs12597511 in the hypertensive group, suggesting that this allele is a risk factor for hypertension and cardiovascular diseases. Conclusion:C allele at rs12597511 of prostasin gene demonstrate as a risk factor for having hypertension in pregnancy.
journal_name
Pak J Med Scijournal_title
Pakistan journal of medical sciencesauthors
Ejaz S,Ali A,Riffat S,Mahmood A,Azim Kdoi
10.12669/pjms.37.1.3666subject
Has Abstractpub_date
2021-01-01 00:00:00pages
109-113issue
1eissn
1682-024Xissn
1681-715Xpii
PJMS-37-109journal_volume
37pub_type
杂志文章abstract:Background and Objective:Brucellosis is an important zoonotic disease and a major public health problem in the Middle East countries including Saudi Arabia. This study has evaluated the seroprevalence of human brucellosis in Wadi Al Dawaser region of Central Saudi Arabia. Methods:The study was conducted for three year...
journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
doi:10.12669/pjms.35.1.55
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVE:To isolate Helicobacter pylori (HP) from the dental plaque of a selected group of children and to compare the oral and salivary findings of patients with those of a healthy control group. METHODS:A total of 70 children aged 5-15 years were included in this study. An intraoral examination was performed for ea...
journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
doi:10.12669/pjms.324.10034
更新日期:2016-07-01 00:00:00
abstract:Background & Objective:Routine physiotherapy has been advocated was an effective treatment for internal shoulder impingement syndrome. However, there is lack of best exercise treatment and lots of studies are under consideration. The objective of the study was to compare the effects of Neuromobilization and routine phy...
journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
doi:10.12669/pjms.36.4.1545
更新日期:2020-05-01 00:00:00
abstract:OBJECTIVE:To evaluate the results of photorefractive keratectomy (PRK) with mitomycin C in myopia correction after five years. METHODS:This is a cross sectional study which included 145 eyes of 74 patients in 18 to 51 years age group that were undergoing Photorefractive keratectomy with mitomycin C using Allegretto Wa...
journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
doi:10.12669/pjms.321.8576
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:To observe the fetomaternal morbidity and mortality with induction of labour in pregnant women with gestational hypertension. METHODS:The subjected study population included was 138 pregnant women with gestational hypertension. These pregnant women were between 34-40 weeks of gestational period in whom labou...
journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
doi:10.12669/pjms.331.10386
更新日期:2017-01-01 00:00:00
abstract:Objective:To compare the effects of high-intensity laser therapy (HILT) and a combination of transcutaneous nerve stimulation (TENS) with ultrasound (US) therapy on pain and functionality in patients with chronic lumbar radiculopathy. Methods:This prospective randomized comparative study was conducted in Department of...
journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
doi:10.12669/pjms.343.14345
更新日期:2018-05-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Chronic obstructive pulmonary disease (COPD) is characterized by chronic incompletely reversible poor airflow and air trapping and usually this debilitating disorder limits the outside activities of the patients depriving them of sunlight which is a rich source of Vitamin D. The objective of th...
journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
doi:10.12669/pjms.333.12397
更新日期:2017-05-01 00:00:00
abstract:OBJECTIVE:To evaluate the Bone Mineral Density (BMD) and diet of teachers of a Govt. College of Home Economics in Lahore. METHODS:It was survey research. Purposive sampling technique was adopted for the selection of 50 teachers from Govt. College of Home Economics of age group 30 - 60 years. RESULTS:About 46% of the ...
journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
doi:10.12669/pjms.314.8433
更新日期:2015-07-01 00:00:00
abstract:OBJECTIVE:To determine site specific carotid intima-media thickness: common-carotid artery and carotid bifurcation in hypercholesterolemia patients as a marker for atherosclerosis. METHODS:Fifty patients with hypercholesterolemia and twenty controls were selected after getting informed consent regarding the investigat...
journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
doi:10.12669/pjms.295.3830
更新日期:2013-09-01 00:00:00
abstract:OBJECTIVE:The objective of the study was to report the socio demographic risk factors of gestational diabetes mellitus (GDM). METHODS:This study was conducted in the Institute of Chemical Sciences, University of Peshawar. In this study 103 GDM and 97 healthy pregnant women (HPW) were registered in Khyber Teaching Hosp...
journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
doi:10.12669/pjms.293.3629
更新日期:2013-05-01 00:00:00
abstract:Objective:To evaluate the diagnostic accuracy of ultrasound in obstructive jaundice taking MRCP as gold standard. Methods:This cross-sectional study was conducted at Dow Institute of Radiology (DIR), Dow University of Health Sciences (DUHS), Karachi from 2nd May 2018 till 2nd November 2018. Both male and female patien...
journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
doi:10.12669/pjms.36.4.1665
更新日期:2020-05-01 00:00:00
abstract:OBJECTIVE:To determine change in practice of mothers having children less than five years of age in five key areas related to child health, growth and development including immunization, feeding during illness, appropriate home treatment for infections and care seeking behavior. METHODS:This was a community based inte...
journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
doi:10.12669/pjms.303.4798
更新日期:2014-05-01 00:00:00
abstract:OBJECTIVES:To investigate the prevalence of obesity and hypertension among University students' and their knowledge and attitude towards risk factors of cardiovascular disease (CVD) in Jeddah,: Saudi Arabia. METHODS:A total of 610 male students were selected for present cross sectional study and their blood pressure (...
journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
doi:10.12669/pjms.314.7953
更新日期:2015-07-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Genetic studies on gestational diabetes (GDM) are relatively scarce; moreover, limited data is available for KCNQ1 polymorphism in Pakistani pregnant women. We aimed to determine the frequency of KCNQ1 rs2237895 in GDM and normal pregnant controls and its association with GDM-related phenotypes...
journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
doi:10.12669/pjms.326.11052
更新日期:2016-11-01 00:00:00
abstract:OBJECTIVE:Ectopic pregnancy in the interstitial part of the Fallopian tubes can be life-threatining considering the thin myometrial tissue surrounding the gestational sac and highly vascularization which may result in catastrophic haemorrhage when interstitium is ruptured. The diagnosis and management is challenging. C...
journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
doi:10.12669/pjms.332.12093
更新日期:2017-03-01 00:00:00
abstract:Objective:To evaluate the effects of traditional massage (TM) on spasticity and gross motor function in children with cerebral palsy (CP). Methods:This randomized control trial (RCT) was conducted with recruitment of 86 children (Dropped out= 11; Analyzed= 75) with spastic CP (diplegia) allocated randomly through seal...
journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
doi:10.12669/pjms.35.5.478
更新日期:2019-09-01 00:00:00
abstract:OBJECTIVE:This study aims to examine Gender Difference in the level of Discrimination and Stigma experienced by people diagnosed with Major Depressive Disorder in Pakistan. It was hypothesized that Women diagnosed with Depression are likely to be experiencing more Discrimination and Internalized Stigma in comparison to...
journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
doi:10.12669/pjms.316.8454
更新日期:2015-11-01 00:00:00
abstract:OBJECTIVES:Ventilator-associated pneumonia (VAP) is a significant cause of hospital-related infections, one that must be prevented due to its high morbidity and mortality. The purpose of this study was to evaluate the incidence and risk factors in patients developing VAP in our intensive care units (ICUs). METHODS:Thi...
journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
doi:10.12669/pjms.324.10381
更新日期:2016-07-01 00:00:00
abstract:OBJECTIVE:To determine mean change in visual acuity, corneal astigmatism and clinical appearance of pterygium after intralesional injection of 5-Fluorouracil. METHODS:This was a Quasi experimental study conducted at Armed Forces Institute of Ophthalmology, Rawalpindi, Pakistan from June 2014 to May 2015. Total 68 eyes...
journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
doi:10.12669/pjms.321.8169
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:To study the effect and clinical value of mammography in the diagnosis of breast lump so as to improve the diagnosis level of breast cancer. METHODS:A retrospective analysis was carried out on clinical data of 110 patients with mammary lump confirmed by pathology to study the compliance of mammography diagno...
journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
doi:10.12669/pjms.324.9384
更新日期:2016-07-01 00:00:00
abstract:OBJECTIVE:To determine the frequency of post-operative pulmonary complications (PPCs) after cardio-pulmonary bypass and association of pre-operative and intraoperative risk factors with incidence of PPCs. METHODS:This study was an observational analysis of five hundred and seventeen (517) patients who underwent cardia...
journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
doi:10.12669/pjms.334.12846
更新日期:2017-07-01 00:00:00
abstract:BACKGROUND & OBJECTIVE:Obstructive ureteral pathologies in adult patients are most commonly due to ureteral strictures and secondary to surgical interventions. In this study, we aimed to compare open and laparoscopic modified Lich-Gregoir ureteral reimplantation with regards to outcomes in benign ureteral pathologies i...
journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
doi:10.12669/pjms.334.12661
更新日期:2017-07-01 00:00:00
abstract:OBJECTIVE:This study investigated the relationship between cardiorespiratory fitness (CRF) and adiposity in young adults. METHODS:Data was collected from 133 students of a medical college of Pakistan. The study was conducted on young adults, aged 17-24 years, recruited from Jinnah Medical & Dental College, Karachi, be...
journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
doi:10.12669/pjms.333.12294
更新日期:2017-05-01 00:00:00
abstract:Objective:Work-related asthma (WRA) is one of the most common occupational diseases. In this study, we aimed to review diagnosing procedures and the characteristics of patients who were diagnosed with WRA. Methods:Between November 2013 and June 2016; 214 patients were referred to our clinic with WRA suspicion by an oc...
journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
doi:10.12669/pjms.335.12923
更新日期:2017-09-01 00:00:00
abstract:OBJECTIVE:To determine the risk factors and complications of puerperal sepsis. METHODS:This was an observational prospective Cohort study conducted from January 2011 to December 2011 at the Obstetrics and Gynaecology Department Liaquat University of Medical & Health Sciences Jamshoro/Hyderabad, Sindh Pakistan. During ...
journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
doi:10.12669/pjms.294.3389
更新日期:2013-07-01 00:00:00
abstract:Objective:A paradigm shift towards a PBL bidirectional dialogic feedback can enhance learners' performance. This study aimed to investigate undergraduate medical students' perceptions of their PBL feedback. Methods:We sent e-mail invitations to a web-based survey to year one and two students at College of Medicine, Ki...
journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
doi:10.12669/pjms.36.7.1778
更新日期:2020-11-01 00:00:00
abstract:OBJECTIVE:The McGrath Video laryngoscope is a newly developed video laryngoscope that significantly improves laryngeal view and facilitates endotracheal intubation in difficult airways. However in patients with normal airway that is not mentioned before. The aim of this study was to compare the McGrath video laryngosco...
journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
doi:10.12669/pjms.324.10037
更新日期:2016-07-01 00:00:00
abstract:Objective:To explore the effectiveness of multidisciplinary comprehensive respiratory rehabilitation in combination with non-invasive positive pressure ventilation (NIPPV) in the treatment of elderly patients with severe chronic obstructive pulmonary disease (COPD). Methods:Eighty-eight elderly patients with severe CO...
journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
doi:10.12669/pjms.35.2.459
更新日期:2019-03-01 00:00:00
abstract:OBJECTIVE:We aimed to evaluate the association between infertility etiology in ICSI pregnancies and preeclampsia; besides, we aimed to discuss the effect of the paternal factor in the pathogenesis of preeclampsia. HYPOTHESIS:We hypothesized that preeclampsia is more common in ICSI pregnancies with male factor. It is k...
journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
doi:10.12669/pjms.301.3982
更新日期:2014-01-01 00:00:00
abstract:Objective:To determine clinical manifestations and laboratory findings in patients with BSS diagnosed through platelet aggregometry followed in a tertiary care hospital in Lahore, Pakistan. Methods:The retrospective study comprised patients who presented in Hematology and Transfusion Medicine Department of The Childre...
journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
doi:10.12669/pjms.35.3.980
更新日期:2019-01-01 00:00:00