The origin of fatal pulmonary emboli: a postmortem analysis of 500 deaths from pulmonary embolism in trauma, surgical, and medical patients.

Abstract:

BACKGROUND:The traditional theory that pulmonary emboli (PE) originate from the lower extremity has been challenged. METHODS:All autopsies performed in Los Angeles County between 2002 and 2010 where PE was the cause of death were reviewed. RESULTS:Of the 491 PE deaths identified, 36% were surgical and 64% medical. Venous dissection for clots was performed in 380 patients; the PE source was the lower extremity (70.8%), pelvic veins (4.2 %), and upper extremity (1.1%). No source was identified in 22.6% of patients. Body mass index (adjusted odds ratio [AOR] 1.044, 95% confidence interval [CI] 1.011 to 1.078, P = .009) and age (AOR 1.018, 95% CI 1.001 to 1.036, P = .042) were independent predictors for identifying a PE source. Chronic obstructive pulmonary disease (AOR .173, 95% CI .046 to .646, P = .009) was predictive of not identifying a PE source. CONCLUSIONS:Most medical and surgical patients with fatal PE had a lower extremity source found, but a significant number had no source identified. Age and body mass index were positively associated with PE source identification. However, a diagnosis of chronic obstructive pulmonary disease was associated with no PE source identification.

journal_name

Am J Surg

authors

Tadlock MD,Chouliaras K,Kennedy M,Talving P,Okoye O,Aksoy H,Karamanos E,Zheng L,Grabo DJ,Rogers C,Noguchi T,Inaba K,Demetriades D

doi

10.1016/j.amjsurg.2014.09.027

subject

Has Abstract

pub_date

2015-06-01 00:00:00

pages

959-68

issue

6

eissn

0002-9610

issn

1879-1883

pii

S0002-9610(14)00625-4

journal_volume

209

pub_type

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