Tumor size as a prognostic factor in patients with stage IIa colon cancer.

Abstract:

BACKGROUND:The aim of this study was to identify stage II colon cancer patients with a high risk of recurrence. METHODS:All patients who underwent surgery for stage II colon cancer (CC) were retrospectively enrolled and sub-grouped according to TNM staging (IIa-b-c) and stage IIa in high (IIaHR) and low risk (IIaLR) according to pathologic features. The primary outcomes measured were the 5-year overall survival (OS) and disease-free survival (DFS). RESULTS:A total of 214 patients were reviewed. Only a maximum tumor diameter<4 cm in the IIaLR group was associated with a higher recurrence rate than a large tumor size (5-year DFS 71.7%vs.87.6%, p = 0.028). The DFS in the large IIaLR CC group was better than that in the IIaHR and IIb-c groups (5-year DFS: 92.7%vs.79.3%, p = 0.023). In contrast, the recurrence rate in the small IIaLR CC group was similar to that in the IIaHR, IIb-c stage CC group. CONCLUSIONS:In stage IIa CC evaluation of the tumor size as a prognostic factor may help identify patients who could benefit from additional postoperative therapy.

journal_name

Am J Surg

authors

Santullo F,Biondi A,Cananzi FCM,Fico V,Tirelli F,Ricci R,Rizzo G,Coco C,Mattana C,D'Ugo D,Persiani R

doi

10.1016/j.amjsurg.2017.03.038

subject

Has Abstract

pub_date

2018-01-01 00:00:00

pages

71-77

issue

1

eissn

0002-9610

issn

1879-1883

pii

S0002-9610(16)30800-5

journal_volume

215

pub_type

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