Treatment of a fatal transplantable erythroleukemia by procedures that lower endogenous erythropoietin.

abstract：:During the past several years, numerous laboratories have reported isolation and purification of proteinase inhibitors from human urine. Many of these molecules were incompletely characterized and some of them may have been artifacts in part because of harsh procedures used for their isolation. Consequently, there is ...

journal_title：Journal of cellular biochemistry

authors： Chawla RK,Lawson DH,Ahmad M,Travis J

更新日期：1992-11-01 00:00:00

abstract：:Wedelolactone is an herbal medicine that is used to treat septic shock, hepatitis and venom poisoning. Although in differentiated and cancer cells, wedelolactone has been identified as anti-inflammatory, growth inhibitory, and pro-apoptotic, the effects of wedelolactone on stem cell differentiation remain largely unkn...

journal_title：Journal of cellular biochemistry

authors： Lim S,Jang HJ,Park EH,Kim JK,Kim JM,Kim EK,Yea K,Kim YH,Lee-Kwon W,Ryu SH,Suh PG

更新日期：2012-11-01 00:00:00

abstract：:Previous studies have indicated that an increased inflammatory response plays an important role in preeclampsia (PE), and rising levels of interleukin (IL)-22 can trigger inflammation and hyperproliferation, leading to increased production of several pro-inflammatory cytokines such as IL-1, IL-6, and IL-8. We aimed to...

journal_title：Journal of cellular biochemistry

authors： Niu Z,Zhao X,Liu H,Quan J,Lin Y,Li J,Wang J,Liu M,Song W,Chen A,Liu S

更新日期：2018-06-01 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) is an incidence rate nearly equal to its mortality rate. The poor prognosis of the disease can be explained by the absence of effective biomarkers for screening and early detection, together with the aggressive behavior and resistance to the currently available chemotherapy. The...

journal_title：Journal of cellular biochemistry

authors： Barati Bagherabad M,Afzaljavan F,ShahidSales S,Hassanian SM,Avan A

更新日期：2019-03-01 00:00:00

abstract：:In order to determine the ability of bovine herpesvirus type 1 (BHV-1) to suppress apoptosis, we examined the effects of BHV-1 infection on sorbitol-induced apoptosis on Madin-Darby bovine kidney (MDBK) cells. BHV-1 suppresses sorbitol-induced apoptosis in a manner similar to that of herpes simplex virus type 1 (HSV-1...

journal_title：Journal of cellular biochemistry

authors： De Martino L,Marfé G,Di Stefano C,Pagnini U,Florio S,Crispino L,Iovane G,Macaluso M,Giordano A

更新日期：2003-05-15 00:00:00

abstract：:Colorectal cancer remains a leading malignancy in humans. The importance of epigenetic modification in the development of this disease is now being recognized. The reversible and dynamic nature of epigenetic modifications provides a promising strategy in colorectal cancer chemoprevention and treatment. Luteolin (LUT),...

journal_title：Journal of cellular biochemistry

authors： Zuo Q,Wu R,Xiao X,Yang C,Yang Y,Wang C,Lin L,Kong AN

更新日期：2018-11-01 00:00:00

abstract：:Active nucleo-cytoplasmic transport is mediated by dynamic signal-mediated pathways. We investigated the effects of transcription inhibitors or fluorescent lectins on nuclear import mediated by nuclear localization signals (NLSs). Therefore, a novel experimental approach that allows the controlled sequential introduct...

journal_title：Journal of cellular biochemistry

authors： Stauber RH,Krätzer F,Schneider G,Hirschmann N,Hauber J,Rosorius O

更新日期：2001-01-01 00:00:00

abstract：:Two monoclonal antibodies that cause changes in the morphology of cultured myogenic cells are described. Antibody JG9 causes myoblasts to round up and causes myotubes to become thin, cable-like structures with multiple round swellings. Antibody JG22 causes both myoblasts and myotubes to become round refractile cells p...

journal_title：Journal of cellular biochemistry

authors： Greve JM,Gottlieb DI

更新日期：1982-01-01 00:00:00

abstract：:Melanoma is a disease which has been shown to be responsive to immune intervention. This has been suggested by reports of spontaneous responses of metastatic disease with strong immune infiltrates, and supported by recent data correlating clinical response after IFNalpha treatment with development of generalized autoi...

journal_title：Journal of cellular biochemistry

authors： Vujanovic L,Butterfield LH

更新日期：2007-10-01 00:00:00

abstract：:Cancer stem cells (CSC) have a central role in driving tumor growth. Since metabolism is becoming an important diagnostic and therapeutic target, characterization of CSC line energetic properties is an emerging need. Embryonic and adult stem cells, compared to differentiated cells, exhibit a reduced mitochondrial acti...

journal_title：Journal of cellular biochemistry

authors： Palorini R,Votta G,Balestrieri C,Monestiroli A,Olivieri S,Vento R,Chiaradonna F

更新日期：2014-02-01 00:00:00

abstract：:Although effective for the treatment of hematological malignancies, the FDA approved proteasome inhibitors bortezomib and carfilzomib have limited efficacy in solid tumors including triple negative breast cancer (TNBC). Chemotherapy is the only option for treating TNBC due to the absence of specific therapeutic target...

journal_title：Journal of cellular biochemistry

authors： Deshmukh RR,Kim S,Elghoul Y,Dou QP

更新日期：2017-05-01 00:00:00

abstract：:Prostate cancer (PCa) cells frequently invade the surrounding stroma, leading to heterogeneous formation of structural atypia. The surrounding stroma contains multiple functionally diverse populations of fibroblasts that trigger numerous changes in PCa cells including motility. Thus, we hypothesized that direct or ind...

journal_title：Journal of cellular biochemistry

authors： Ishii K,Nakagawa Y,Matsuda C,Katoh D,Ichishi M,Shirai T,Hirokawa Y,Fujiwara M,Sugimura Y,Watanabe M

更新日期：2021-01-22 00:00:00

abstract：:Obesity and aging lead to abnormal transforming growth factor-β1 (TGF-β1) signaling in the hypothalamus, triggering the imbalance on glucose metabolism and energy homeostasis. Here, we determine the effect of acute exercise on TGF-β1 expression in the hypothalamus of two models of obesity in mice. The bioinformatics a...

journal_title：Journal of cellular biochemistry

authors： Silva VRR,Lenhare L,Katashima CK,Morari J,M-Assis A,Gaspar RS,da Silva ASR,Moura LP,Pauli JR,Cintra DE,Velloso LA,Ropelle ER

更新日期：2019-10-01 00:00:00

abstract：:Recent studies have shown that long noncoding RNAs (lncRNA) HOX transcript antisense intergenic RNA (HOTAIR) polymorphisms are associated with cancer susceptibility. The greatest threat to women's health among a variety of cancers is breast cancer (BC), cervical cancer (CC), and ovarian cancer (OC), and the incidence ...

journal_title：Journal of cellular biochemistry

authors： Li J,Liu R,Tang S,Feng F,Wang X,Qi L,Liu C,Yao Y,Sun C

更新日期：2018-11-28 00:00:00

abstract：:Thrombin increases the cytosolic Ca(2+) concentrations and induces NO production by activating proteinase-activated receptor 1 (PAR(1)) in vascular endothelial cells. The store-operated Ca(2+) influx is a major Ca(2+) influx pathway in non-excitable cells including endothelial cells and it has been reported to play a ...

journal_title：Journal of cellular biochemistry

authors： Hirano K,Hirano M,Hanada A

更新日期：2009-10-01 00:00:00

abstract：:Pre-adipocyte 3T3-L1 cells, after an appropriate induction stimulus, proceed through a defined change in morphology as differentiation progresses. Transforming growth factor beta 1 (TGF beta 1) is able to block the morphological and biochemical changes which occur with differentiation of these cells if given within 36...

journal_title：Journal of cellular biochemistry

authors： Bortell R,Owen TA,Ignotz R,Stein GS,Stein JL

更新日期：1994-02-01 00:00:00

abstract：:Fibroblast-collagen matrix contraction has been used as a model system to study how cells organize connective tissue. Previous work showed that lysophosphatidic acid (LPA)-stimulated floating collagen matrix contraction is independent of Rho kinase while platelet-derived growth factor (PDGF)-stimulated contraction is ...

journal_title：Journal of cellular biochemistry

authors： Abe M,Sogabe Y,Syuto T,Yokoyama Y,Ishikawa O

更新日期：2007-12-01 00:00:00

abstract：:We have constructed a phage lambda library of liver DNA fragments from West African patient who died of liver failure due to advanced hepatocellular carcinoma. Four hepatitis B virus (HBV) DNA-carrying recombinants have been isolated, one clone (lambda IA22) being analyzed in greatest detail. It contains approximately...

journal_title：Journal of cellular biochemistry

authors： Dejean A,Carloni G,Bréchot C,Tiollais P,Wain-Hobson S

更新日期：1982-01-01 00:00:00

abstract：:To study hematopoietic differentiation a variety of in vitro systems have been established using hematopoietic precursors derived from various explanted adult and fetal tissues. In this prospective we describe and discuss the potential of a novel system for studying the earliest stages of hematopoietic development. In...

journal_title：Journal of cellular biochemistry

authors： Snodgrass HR,Schmitt RM,Bruyns E

更新日期：1992-07-01 00:00:00

abstract：:Phosphoinositides (PIs) and proteins involved in the PI signaling pathway are distributed in the nucleus as well as at the plasma membrane and in the cytoplasm, although their nuclear localization mechanisms have not been clarified in detail. Generally, proteins that shuttle between the cytoplasm and nucleus contain n...

journal_title：Journal of cellular biochemistry

authors： Yagisawa H

更新日期：2006-02-01 00:00:00

abstract：BACKGROUND:Inflammatory bowel disease (IBD) is one of the most important immune-mediated disorders of the gastrointestinal tract. Besides, IBD is associated with numerous extraintestinal complications such as venous thromboembolism (VTE), an important risk factor for vascular complications, which results in the increas...

journal_title：Journal of cellular biochemistry

authors： Asadzadeh-Aghdaei H,Mashayekhi K,Koushki K,Azimzadeh P,Rostami-Nejad M,Amani D,Chaleshi V,Haftcheshmeh SM,Sahebkar A,Zali MR

更新日期：2019-09-01 00:00:00

abstract：:Extracellular nucleotides and nucleosides have emerged as important elements regulating tissue homeostasis. Acting through specific receptors, have the ability to control gene expression patterns to direct cellular fate. We observed that SKOV-3 cells express the ectonucleotidases: ectonucleotide pyrophosphatase 1 (ENP...

journal_title：Journal of cellular biochemistry

authors： Martínez-Ramírez AS,Díaz-Muñoz M,Battastini AM,Campos-Contreras A,Olvera A,Bergamin L,Glaser T,Jacintho Moritz CE,Ulrich H,Vázquez-Cuevas FG

更新日期：2017-12-01 00:00:00

abstract：:Hormone replacement therapy (HRT) for post-menopausal symptoms in diabetes is associated with increased risk of coronary heart disease and stroke. Therefore, there is a need for new HRT with no adverse effects on diabetic post-menopausal women. We developed peptides as potential estrogen mimetic compounds and now we e...

journal_title：Journal of cellular biochemistry

authors： Somjen D,Knoll E,Gayer B,Kasher R,Kohen F,Stern N

更新日期：2010-08-01 00:00:00

abstract：:IFI 16 is a member of the HIN-200 family of transcriptional regulators that suppress cell growth, modulate the cell cycle and have been linked to cellular differentiation. We hypothesized that the activity of IFI 16 depends on its level of expression and therefore studied the transcriptional activity of the IFI 16 pro...

journal_title：Journal of cellular biochemistry

authors： Clarke CJ,Apostolidis V,Hii LL,Gough DJ,Trapani JA,Johnstone RW

更新日期：2003-05-01 00:00:00

abstract：:Recently increasing emphasis is placed on preventive health and management of chronic comorbidities avoiding long-term toxicities of antiretroviral therapy (ART). Drawing from this background we decided to use the Saos-2, osteosarcoma cell line, as a cellular model, to evaluate the effects of some antiretroviral drugs...

journal_title：Journal of cellular biochemistry

authors： Esposito V,Perna A,Lucariello A,Carleo MA,Viglietti R,Sangiovanni V,Coppola N,Guerra G,De Luca A,Chirianni A

更新日期：2015-10-01 00:00:00

abstract：:Understanding how the information is conveyed from outside to inside the cell is a critical challenge for all biologists involved in signal transduction. The flow of information initiated by cell-cell and cell-extracellular matrix contacts is mediated by the formation of adhesion complexes involving multiple proteins....

journal_title：Journal of cellular biochemistry

authors： Lelièvre SA,Bissell MJ

更新日期：1998-01-01 00:00:00

abstract：:Matrix metalloproteinase-1 (MMP-1) is one of only a few enzymes with the ability to degrade the stromal collagens (types I and III) at neutral pH, and high expression of MMP-1 has been associated with aggressive and invasive cancers. We recently reported a single nucleotide insertion/deletion polymorphism (SNP) in the...

journal_title：Journal of cellular biochemistry

authors： Benbow U,Tower GB,Wyatt CA,Buttice G,Brinckerhoff CE

更新日期：2002-01-01 00:00:00

abstract：:ZC3H12D belongs to a recently discovered family of proteins containing four members of which the most studied and best described is the RNase ZC3H12A (MCPIP1/Regnase-1). ZC3H12A is a crucial negative regulator of inflammation. It accelerates the turnover of transcripts of a spectrum of proinflammatory cytokines, as we...

journal_title：Journal of cellular biochemistry

authors： Wawro M,Kochan J,Krzanik S,Jura J,Kasza A

更新日期：2017-03-01 00:00:00

abstract：:Electromagnetic field (EMF) exposures have been shown to induce heat shock proteins (HSPs), which help to maintain the conformation of cellular proteins during periods of stress. We have previously reported that short-term exposure of chick embryos to either 60 Hz (extremely low frequency: ELF), or radio-frequency (RF...

journal_title：Journal of cellular biochemistry

authors： Di Carlo A,White N,Guo F,Garrett P,Litovitz T

更新日期：2002-01-01 00:00:00

abstract：:Homocysteine-thiolactone (HcyT) is a toxic product whose synthesis is directly proportional to plasma homocysteine (Hcy) levels. Previous studies demonstrated that the interaction between HcyT and low density lipoproteins (LDL) induces the formation of homocystamide-LDL adducts (Hcy-LDL). Structural and functional alt...

journal_title：Journal of cellular biochemistry

authors： Ferretti G,Bacchetti T,Moroni C,Vignini A,Nanetti L,Curatola G

更新日期：2004-05-15 00:00:00