Abstract:
:In this paper, we develop a simple diagnostic test for the random-effects distribution in mixed models. The test is based on the gradient function, a graphical tool proposed by Verbeke and Molenberghs to check the impact of assumptions about the random-effects distribution in mixed models on inferences. Inference is conducted through the bootstrap. The proposed test is easy to implement and applicable in a general class of mixed models. The operating characteristics of the test are evaluated in a simulation study, and the method is further illustrated using two real data analyses.
journal_name
Stat Methods Med Resjournal_title
Statistical methods in medical researchauthors
Efendi A,Drikvandi R,Verbeke G,Molenberghs Gdoi
10.1177/0962280214564721subject
Has Abstractpub_date
2017-04-01 00:00:00pages
970-983issue
2eissn
0962-2802issn
1477-0334pii
0962280214564721journal_volume
26pub_type
杂志文章abstract::Stochastic transmission dynamic models are needed to quantify the uncertainty in estimates and predictions during outbreaks of infectious diseases. We previously developed a calibration method for stochastic epidemic compartmental models, called Multiple Shooting for Stochastic Systems (MSS), and demonstrated its comp...
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doi:10.1177/0962280218805780
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journal_title:Statistical methods in medical research
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journal_title:Statistical methods in medical research
pub_type: 杂志文章,评审
doi:10.1191/0962280205sm389oa
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journal_title:Statistical methods in medical research
pub_type: 杂志文章
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journal_title:Statistical methods in medical research
pub_type: 杂志文章
doi:10.1177/0962280215598806
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abstract::In the clinical development of some new infectious disease drugs, early clinical pharmacology trials may predict with high confidence that the efficacious doses are well below the range of the safety margin. In this case, a dose-ranging study may be unnecessary after a proof-of-concept (PoC) study testing the highest ...
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journal_title:Statistical methods in medical research
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doi:10.1177/0962280206071839
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journal_title:Statistical methods in medical research
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journal_title:Statistical methods in medical research
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更新日期:2017-06-01 00:00:00
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pub_type: 评论,信件
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