Radioembolization dosimetry: the road ahead.

Abstract:

:Methods for calculating the activity to be administered during yttrium-90 radioembolization (RE) are largely based on empirical toxicity and efficacy analyses, rather than dosimetry. At the same time, it is recognized that treatment planning based on proper dosimetry is of vital importance for the optimization of the results of RE. The heterogeneous and often clustered intrahepatic biodistribution of millions of point-source radioactive particles poses a challenge for dosimetry. Several studies found a relationship between absorbed doses and treatment outcome, with regard to both toxicity and efficacy. This should ultimately lead to improved patient selection and individualized treatment planning. New calculation methods and imaging techniques and a new generation of microspheres for image-guided RE will all contribute to these improvements. The aim of this review is to give insight into the latest and most important developments in RE dosimetry and to suggest future directions on patient selection, individualized treatment planning, and study designs.

authors

Smits ML,Elschot M,Sze DY,Kao YH,Nijsen JF,Iagaru AH,de Jong HW,van den Bosch MA,Lam MG

doi

10.1007/s00270-014-1042-7

subject

Has Abstract

pub_date

2015-04-01 00:00:00

pages

261-9

issue

2

eissn

0174-1551

issn

1432-086X

journal_volume

38

pub_type

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