当前位置： SCI文献检索 > JOURNAL OF CATARACT AND REFRACTIVE SURGERY期刊下所有文献 > In vitro antimicrobial analysis of aqueous humor after topical application of moxifloxacin hydrochloride 0.5%.

In vitro antimicrobial analysis of aqueous humor after topical application of moxifloxacin hydrochloride 0.5%.

Abstract：

PURPOSE:To evaluate the in vitro antimicrobial activity of aqueous humor in patients who had preoperative topical application of moxifloxacin hydrochloride 0.5%. SETTING:Department of Ophthalmology, Santa Casa de Misericórdia de São Paulo, Brazil. DESIGN:Comparative case series. METHODS:Twenty-nine eyes from 29 cataract surgery patients were included in this study. In the study group (n = 15 eyes), 3 topical applications of moxifloxacin hydrochloride 0.5% were administered preoperatively; in the control group (n = 14 eyes), no topical applications were administered. Aqueous humor samples were collected and stored in sterile microtubes at -80°C until analysis. Antimicrobial analysis was performed using standard strains with standard sterile filter paper disks. Inhibition halos were measured in millimeters, and both bactericidal and bacteriostatic effects were analyzed. RESULTS:Inhibition halos were observed on most of the study group plates except those with Streptococcus pneumoniae: Escherichia coli (13.93 mm ± 0.64 [SD]), Klebsiella pneumoniae (10.63 ± 0.61 mm), Staphylococcus aureus (7.47 ± 0.68 mm), and S epidermidis (4.20 ± 3.33 mm) The differences between the mean inhibition halo diameters were statistically significant (P < .0001) in all samples. No bactericidal effect was observed against any of the microorganisms studied. CONCLUSIONS:After topical application of moxifloxacin 0.5%, aqueous humor showed bacteriostatic effect against E coli, K pneumoniae, S aureus, and S epidermidis. No bactericidal effect was observed against any of the microorganisms evaluated. No antimicrobial effect against S pneumoniae was observed. FINANCIAL DISCLOSURE:No author has a financial or proprietary interest in any material or method mentioned.

journal_name

J Cataract Refract Surg

journal_title

Journal of cataract and refractive surgery

authors

de Miranda AP,Silva CB,Mimica LM,Moscovici BK,Malavazzi GR,Hida RY

doi

10.1016/j.jcrs.2014.11.010

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

135-9

issue

1

eissn

0886-3350

issn

1873-4502

pii

S0886-3350(14)01535-1

journal_volume

41

pub_type

杂志文章

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