Abstract：
OBJECTIVE:Our goal in this study aims to explain the polypharmacological mechanism at the molecular level responsible for the effectiveness of a traditional Chinese medicine (TCM) prescription FTZ to treat hyperlipidemia and related disease. DESIGN:By MDL(®) ISIS_Base 2.5, we constructed a compound database based on the FTZ constituents, which were detected in the rat serum after oral administration of the TCM through ultra-performance liquid chromatography/quadruple-time-of-flight mass-spectrometry (UPLC/Q-TOF-MS/MS) method. After validation of the virtual docking system, we used molecular screening by LigandFit which is a computational method for the shape-directed rapid docking of ligands to target protein active sites, to investigate the interactions between the components in database and lipid-modulating targets in the liver. RESULTS:In the prescription FTZ ingredients, there were sixteen constituents including jatrorrhizine, etc. showed potential effects towards the hyperlipidemia-related targets: HMG-CoA reductase (HMGR), squalene synthase (SQS), oxidosqualene cyclase (OSC), cholesteryl ester transfer protein (CETP), liver X receptor (LXR), farnesoid X receptor (FXR) and peroxisome proliferator-activated receptors (PPARα and PPARγ). Among the eight herbs in prescription FTZ, Rhizoma Coptidis (RC) plays the most important role in whole effect from FTZ on hyperlipidemia related disease. CONCLUSIONS:Our research demonstrated that Chinese medicine formula FTZ has multi-target synergistic effect on hyperlipidemia and suggests the pharmacodynamic material basis could be jatrorrhizine, berberrubine, berberine and salidroside.
journal_name
Complement Ther Medjournal_title
Complementary therapies in medicineauthors
Wang L,Tao W,Luo D,Hu Y,Bei W,Guo Jdoi
10.1016/j.ctim.2014.08.002subject
Has Abstractpub_date
2014-10-01 00:00:00pages
887-93issue
5eissn
0965-2299issn
1873-6963pii
S0965-2299(14)00130-7journal_volume
22pub_type
杂志文章abstract：BACKGROUND:Colonic diverticula develop in at least 60% of elderly patients. Less than 25% of these develop diverticulitis. Recurrent episodes are experienced by about 13% of the symptomatic patients. The effect on prevention of recurrent diverticulitis of currently used therapies is controversial. Surgical colon resect...
journal_title：Complementary therapies in medicine
pub_type： 杂志文章
doi：10.1016/j.ctim.2018.03.013
更新日期：2018-10-01 00:00:00
abstract：OBJECTIVE:The primary aim was to describe the characteristics of acupuncture patients and in particular the main problem or symptom for which they were seeking treatment. Our secondary aim was to compare the profiles of acupuncture patients with those of a patient survey undertaken in 1988. METHODS:We used the data fr...
journal_title：Complementary therapies in medicine
pub_type： 杂志文章
doi：10.1016/j.ctim.2005.07.006
更新日期：2006-03-01 00:00:00
abstract：OBJECTIVES:To assess the experiences of a veteran initiated horticultural therapy garden during their 28-day inpatient Substance Abuse Residential Rehabilitation Treatment Program (SARRTP). DESIGN:Retrospective study. SETTING:Veterans Affairs Medical Center (VAMC), Salem, Virginia, USA INTERVENTIONS: Group interviews...
journal_title：Complementary therapies in medicine
pub_type： 杂志文章
doi：10.1016/j.ctim.2017.10.013
更新日期：2018-02-01 00:00:00
abstract：BACKGROUND:This is the first part of a larger spectrum systematic review which aims to identify and evaluates the effectiveness of all different non-pharmacological acupuncture techniques used for COPD. In this first publication, we describe the results of filiform needle acupuncture METHODS: Randomised controlled tria...
journal_title：Complementary therapies in medicine
pub_type： 杂志文章,meta分析
doi：10.1016/j.ctim.2019.08.016
更新日期：2019-12-01 00:00:00
abstract：OBJECTIVES:Mind-body practices (MBP), such as Yoga or Tai-Chi, have increased in popularity in the past 25 years in the US. These activities may help promote a less sedentary lifestyle and may have positive effects on health. The objective of the present study is to understand the prevalence and trends of MBP in US adu...
journal_title：Complementary therapies in medicine
pub_type： 杂志文章
doi：10.1016/j.ctim.2020.102501
更新日期：2020-08-01 00:00:00
abstract：BACKGROUND & OBJECTIVE(S):Bertholletia excelsa is a rich herbal source of anti-oxidants and phenols. The goal of this study is to evaluation the effect of bertholletia excelsa nut on body weight, C-reactive protein (CRP) and lipid profile. METHODS:A literature search was conducted in PubMed, Scopus and Web of sciences...
journal_title：Complementary therapies in medicine
pub_type： 杂志文章,评审
doi：10.1016/j.ctim.2020.102636
更新日期：2020-11-30 00:00:00
abstract：OBJECTIVE:To identify the effect of some herbal products on insulin resistance. Regarding the scientific evidences existing about ginger, this research was therefore carried out to identify the effect of ginger supplementation on insulin resistance and glycemic indices in diabetes mellitus. METHODS:This is a randomize...
journal_title：Complementary therapies in medicine
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.ctim.2013.12.017
更新日期：2014-02-01 00:00:00
abstract：OBJECTIVES:To examine the long-term effects of foot-bathing therapy, using different water temperatures, on the sleep quality of older adults living in nursing homes. DESIGN:A quasi-experimental study design with non-equivalent control group. SETTINGS:Thirty participants were recruited from a nursing home in Gyeong-g...
journal_title：Complementary therapies in medicine
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.ctim.2016.02.005
更新日期：2016-06-01 00:00:00
abstract：:A custom-made questionnaire was sent to all UK medical charities in 1999 and again in 2002. Its primary aim was to assess the commitment of these institutions towards funding research in complementary and alternative medicine (CAM). Sixty-two (1999) and 60 (2002) answers were received corresponding to response rates o...
journal_title：Complementary therapies in medicine
pub_type： 杂志文章
doi：10.1016/s0965-2299(03)00061-x
更新日期：2003-09-01 00:00:00
abstract：OBJECTIVES:This pilot study analyses the effect and feasibility of hydrotherapeutic Kneipp arm affusions on secretory immunoglobulin A (sIgA) and classic cold symptoms in children 3-6 years of age. STUDY DESIGN:A controlled, non-randomized, clinical pilot study was undertaken. INTERVENTION:This descriptive hydrothera...
journal_title：Complementary therapies in medicine
pub_type： 杂志文章
doi：10.1016/j.ctim.2020.102637
更新日期：2020-11-28 00:00:00
abstract：OBJECTIVES:The physiological changes that occur during pregnancy, including increased blood volume and cardiac output, can affect hemodynamic control, most profoundly with positional changes that affect venous return to the heart. By using Osteopathic Manipulative Treatment (OMT), a body-based modality theorized to aff...
journal_title：Complementary therapies in medicine
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.ctim.2013.08.008
更新日期：2013-12-01 00:00:00
abstract：:Cardiovascular disease (CVD) is the leading causes of mortality across the world. Some earlier studies have revealed the beneficial effects of fenugreek on the risk factors for CVDs. However, a systematic review and meta-analysis is needed to clarify its effectiveness. Accordingly, the purpose of this study was to ass...
journal_title：Complementary therapies in medicine
pub_type： 杂志文章,评审
doi：10.1016/j.ctim.2020.102416
更新日期：2020-08-01 00:00:00
abstract：OBJECTIVES:Cupping worldwide has been part of traditional medicine systems and is in the western world used as CAM therapy mainly for treating pain syndromes. The mode of action is up to now unclear. In order to investigate its mechanism we measured in parallel metabolic changes in the tissue under the cupping glass an...
journal_title：Complementary therapies in medicine
pub_type： 杂志文章
doi：10.1016/j.ctim.2013.12.013
更新日期：2014-02-01 00:00:00
abstract：PURPOSE:Given the infancy and evolving complexity of medicinal marijuana, an evolving political landscape, and the growing frequency of its use in cancer care, it is important for oncologists to be actively engaged in developing and successfully implementing clinical trials focusing on medical marijuana. The purpose of...
journal_title：Complementary therapies in medicine
pub_type： 杂志文章
doi：10.1016/j.ctim.2020.102336
更新日期：2020-03-01 00:00:00
abstract：BACKGROUND:Previous studies in Parkinson's Disease (PD) have described benefits of dance for motor and non-motor outcomes, yet few studies specifically look at Dance Therapy (DT) as a specific psychotherapeutic model for PD. DT is the psychotherapeutic use of movement to improve physical, emotional, cognitive, and soci...
journal_title：Complementary therapies in medicine
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.ctim.2018.07.005
更新日期：2018-10-01 00:00:00
abstract：:WHO Traditional Medicine Strategy 2014-23 recommended evidence-based healthcare (EBHC) education for traditional and complementary medicine (T&CM) professionals, including Chinese medicine practitioners (CMPs). We evaluated the impact of a customized educational workshop on Hong Kong CMPs' knowledge, attitude and prac...
journal_title：Complementary therapies in medicine
pub_type： 杂志文章
doi：10.1016/j.ctim.2019.05.004
更新日期：2019-08-01 00:00:00
abstract：OBJECTIVES:To report on the potential effectiveness of hypocaloric, plant-based short-term dietary oatmeal interventions in the treatment of insulin resistance in critically ill patients on the intensive care unit. CLINICAL FEATURES AND OUTCOME:A 67-year-old female with type 2 diabetes was admitted to our hospital wit...
journal_title：Complementary therapies in medicine
pub_type： 杂志文章
doi：10.1016/j.ctim.2019.07.019
更新日期：2019-10-01 00:00:00
abstract：OBJECTIVES:(1) To replicate a study of the efficacy of Argentum nitricum 12X in the reduction of test anxiety as demonstrated previously. (2) To investigate the correlation between individuals identified to match the A. nitricum profile and the reduction of test anxiety. To compare traditionally prepared homeopathic A....
journal_title：Complementary therapies in medicine
pub_type： 临床试验,杂志文章
doi：10.1016/s0965-2299(03)00059-1
更新日期：2003-06-01 00:00:00
abstract：OBJECTIVE:Breast cancer survivors often turn to the internet as an information resource when deciding whether to use complementary and alternative medicine (CAM) but their use of online CAM-related resources is poorly understood. The objective was to explore breast cancer survivors' use of the internet when making deci...
journal_title：Complementary therapies in medicine
pub_type： 杂志文章
doi：10.1016/j.ctim.2017.06.007
更新日期：2017-08-01 00:00:00
abstract：OBJECTIVES:Traditional Chinese medicine are commonly used for treatment of asthma. However, there are only very limited data about its efficacy in children. Therefore, we aimed to determine the efficacy of augmented Yu Ping Feng San (aYPFS) as an add-on to oral montelukast compared with montelukast alone for treatment ...
journal_title：Complementary therapies in medicine
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.ctim.2016.10.010
更新日期：2016-12-01 00:00:00
abstract：:The description of individual cases is probably the most important didactic tool for teaching in medicine, especially in complementary and alternative medicine (CAM). However, only very rarely is the information provided in traditional single case reports sufficient to answer scientific questions. These reports typica...
journal_title：Complementary therapies in medicine
pub_type： 杂志文章,评审
doi：10.1016/j.ctim.2013.04.006
更新日期：2013-08-01 00:00:00
abstract：OBJECTIVES:To assess chiropractic (DC) and naturopathic doctors' (ND) pediatric care natural health product (NHP) recommendations. DESIGN:Surveys were developed in collaboration with DC and ND educators, and delivered as an on-line national survey. NHP dose, form of delivery, and indications across pediatric age range...
journal_title：Complementary therapies in medicine
pub_type： 杂志文章
doi：10.1016/j.ctim.2019.02.001
更新日期：2019-04-01 00:00:00
abstract：OBJECTIVES:To develop simplified constitutional indications for homeopathic medicines so that parents of children with recurrent upper respiratory tract infection (URTI) could choose homeopathic medicines for their children more "accurately", and to subsequently evaluate if these choices match the prescriptions of trai...
journal_title：Complementary therapies in medicine
pub_type： 杂志文章
doi：10.1016/j.ctim.2004.09.004
更新日期：2004-06-01 00:00:00
abstract：OBJECTIVES:To determine whether utilizing yoga as an adjunctive therapy to the medical standard of care for adolescents with inflammatory bowel disease (IBD) is: (1) feasible and acceptable, (2) effective in reducing disease severity, intestinal inflammation and improving wellness. DESIGN:Prospective, non-randomized, ...
journal_title：Complementary therapies in medicine
pub_type： 临床试验,杂志文章
doi：10.1016/j.ctim.2018.09.007
更新日期：2018-12-01 00:00:00
abstract：BACKGROUND & OBJECTIVE(S):Obesity is a worldwide epidemic and a common medical condition associated with a variety of chronic diseases. Cereal beta-glucans are soluble fibers with potential health benefits. A number of randomized controlled trials (RCTs) have investigated the effect of cereal beta-glucan consumption on...
journal_title：Complementary therapies in medicine
pub_type： 杂志文章,meta分析
doi：10.1016/j.ctim.2019.01.018
更新日期：2019-04-01 00:00:00
abstract：:Writers on homoeopathy frequently refer to classical homoeopathy, usually with the implication that this is the most complete and authoritative version of Hahnemann's views. However, such claims do not correspond with the historical facts. Homoeopathy arrived in the USA early in the 19th century and there underwent co...
journal_title：Complementary therapies in medicine
pub_type： 历史文章,杂志文章,评审
doi：10.1016/s0965-2299(99)80085-5
更新日期：1999-06-01 00:00:00
abstract：OBJECTIVES:This pilot study examined the potential efficacy of cranial electric stimulation for the treatment of insomnia. DESIGN:The researchers tested the hypothesis through a randomized, double-blind, and placebo controlled clinical trial. The researchers approached eligible subjects who scored 21 or above on the P...
journal_title：Complementary therapies in medicine
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.ctim.2012.11.007
更新日期：2013-02-01 00:00:00
abstract：OBJECTIVES:Growing interest in integrative medicine motivates examination of who seeks integrative care, and why. By examining differences in demographics and complementary and alternative medicine (CAM) use between patients recruited from Japanese Kampo (traditional herbal medicine) versus biomedical clinics, this stu...
journal_title：Complementary therapies in medicine
pub_type： 杂志文章
doi：10.1016/j.ctim.2019.06.003
更新日期：2019-10-01 00:00:00
abstract：OBJECTIVE:To investigate how individuals expressed rationales for their beliefs regarding efficacy of acupuncture. METHODS:Qualitative data from participants of two different randomized sham-controlled trials, of relaxing (non-cancer volunteers of the general population) or antiemetic (patients with cancer undergoing ...
journal_title：Complementary therapies in medicine
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.ctim.2018.04.006
更新日期：2018-08-01 00:00:00
abstract：:The aim of this study was to evaluate the acute effects of light-emitting diode therapy (LEDT) on cardiopulmonary adjustments and muscle oxygenation dynamics during transition to moderate exercise, as well as in glucose and lactate levels in patients with type 2 diabetes mellitus (T2DM). Sixteen individuals with T2DM ...
journal_title：Complementary therapies in medicine
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/j.ctim.2018.11.015
更新日期：2019-02-01 00:00:00
