Endocytoscopy is a promising modality with high diagnostic accuracy for gastric cancer.

Abstract:

BACKGROUND AND STUDY AIM:Endocytoscopy (ECS) enables in vivo microscopic imaging, which allows analysis of mucosal structures at the cellular level; however, limited data are available on the validity of ECS in the stomach. The aim of this study was to evaluate the feasibility of ECS in the diagnosis of early gastric cancer. PATIENTS AND METHODS:Gastric lesions that were the targets of histopathological diagnosis by endoscopic submucosal dissection or biopsy specimen were prospectively enrolled and evaluated using a single charge-coupled device-integrated endocytoscope, following double staining with crystal violet and methylene blue. High grade ECS atypia was defined according to specific irregularities in gland structure and cell nuclei. The primary end point was the accuracy of ECS diagnosis for gastric cancer, using histopathological diagnosis as the gold standard. RESULTS:A total of 82 lesions were investigated, including 23 early gastric cancers, 10 gastric adenomas, and 49 non-neoplastic lesions. Ten lesions could not be clearly observed by ECS because of poor staining due to viscous mucus or plaque; thus, assessability rates with ECS were 88 % in total and 91 % for gastric cancer. High grade ECS atypia was observed in 86 % of assessable gastric cancers, but not in any cases of gastric adenomas or non-neoplastic lesions. The sensitivity, specificity, positive and negative predictive values of high grade ECS atypia as the criterion for the diagnosis of gastric cancer were 86 %, 100 %, 100 %, and 94 %, respectively. No serious complications occurred during or after the examinations. CONCLUSION:ECS is a clinically feasible modality to obtain in vivo histology, with high diagnostic accuracy in gastric cancer.

journal_name

Endoscopy

journal_title

Endoscopy

authors

Kaise M,Ohkura Y,Iizuka T,Kimura R,Nomura K,Kuribayashi Y,Yamada A,Yamashita S,Furuhata T,Kikuchi D,Ogawa O,Matsui A,Mitani T,Hoteya S

doi

10.1055/s-0034-1377965

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

19-25

issue

1

eissn

0013-726X

issn

1438-8812

journal_volume

47

pub_type

临床试验,杂志文章
  • Endoscopic hemostasis by local injection of epinephrine and polidocanol in bleeding ulcer. A prospective randomized trial.

    abstract::The present prospective randomized trial has been carried out to assess the efficacy of the endoscopic injection of epinephrine plus polidocanol, in the prompt treatment of upper gastrointestinal bleeding due to peptic lesions. Over a period of one year, 72 patients were admitted to the study. Thirty-six of these unde...

    journal_title:Endoscopy

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1055/s-2007-1013023

    authors: Balanzó J,Sainz S,Such J,Espinós JC,Guarner C,Cussó X,Monés J,Vilardell F

    更新日期:1988-11-01 00:00:00

  • Endoscopic ultrasound-guided rendezvous for biliary access after failed cannulation.

    abstract:INTRODUCTION:Selective cannulation fails in approximately 3 % of endoscopic retrograde cholangiography (ERC) procedures. An endoscopic ultrasound-guided rendezvous technique (EUS - RV) may salvage failed cannulation. The aims of the current study were to determine the safety and efficacy of EUS - RV. METHODS:A total o...

    journal_title:Endoscopy

    pub_type: 杂志文章

    doi:10.1055/s-0030-1256871

    authors: Iwashita T,Lee JG,Shinoura S,Nakai Y,Park DH,Muthusamy VR,Chang KJ

    更新日期:2012-01-01 00:00:00

  • Clinical features, pathophysiology and relevance of portal hypertensive gastropathy.

    abstract::The frequency and importance of gastric mucosal lesions in patients with portal hypertension have been increasingly recognized in recent years. This article describes the clinical and endoscopic features of portal hypertensive gastropathy and reviews the current state of knowledge concerning the pathophysiology and tr...

    journal_title:Endoscopy

    pub_type: 杂志文章,评审

    doi:10.1055/s-2007-1010663

    authors: Smart HL,Triger DR

    更新日期:1991-07-01 00:00:00

  • Future developments in total Barrett's eradication: the surgeon's view.

    abstract::Endoscopic therapies for the treatment of complicated Barret's esophagus should be embraced by the surgical community. While esophagectomy remains the standard of care for early esophageal neoplasia in many centers, endoscopic techniques are being increasingly utilizid. As refinements in both endoscopic and surgical a...

    journal_title:Endoscopy

    pub_type: 杂志文章,评审

    doi:10.1055/s-2008-1077783

    authors: Watson TJ,Peters JH

    更新日期:2008-12-01 00:00:00

  • Capnographic monitoring of midazolam and propofol sedation during ERCP: a randomized controlled study (EndoBreath Study).

    abstract:BACKGROUND AND STUDY AIMS:This was to determine whether intervention based on additional capnographic monitoring reduces the incidence of hypoxemia during midazolam and propofol sedation for endoscopic retrograde cholangiopancreatography (ERCP). METHODS:Patients (American Society of Anesthesiologists [ASA] I – IV) sch...

    journal_title:Endoscopy

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1055/s-0034-1393117

    authors: Klare P,Reiter J,Meining A,Wagenpfeil S,Kronshage T,Geist C,Heringlake S,Schlag C,Bajbouj M,Schneider G,Schmid RM,Wehrmann T,von Delius S,Riphaus A

    更新日期:2016-01-01 00:00:00

  • Safe and effective digestive endoscopic resection in patients with cirrhosis: a single-center experience.

    abstract:BACKGROUND:Endoscopic resection has developed over the years. The main complications are perforation and bleeding. This study aimed to evaluate safety and effectiveness of digestive endoscopic resection in patients with cirrhosis. METHODS:This retrospective, open-label, single-center study included all consecutive pat...

    journal_title:Endoscopy

    pub_type: 杂志文章

    doi:10.1055/a-1089-9459

    authors: Miaglia C,Guillaud O,Rivory J,Lépilliez V,Chambon-Augoyard C,Hervieu V,Ponchon T,Dumortier J,Pioche M

    更新日期:2020-04-01 00:00:00

  • Follow-up of adult celiac patients: which noninvasive test reflects mucosal status most reliably?1.

    abstract:UNLABELLED:SPECIFIC AUTHOR CONTRIBUTIONS: Andreas Vécsei, MD, and Ulrike Graf wrote the manuscript. All authors contributed to study design, data collection and analysis, and approved the final draft for submission. The corresponding author declares that the manuscript is submitted on behalf of all authors. BACKGROUND...

    journal_title:Endoscopy

    pub_type: 杂志文章

    doi:10.1055/s-0028-1103484

    authors: Vécsei AK,Graf UB,Vogelsang H

    更新日期:2009-02-01 00:00:00

  • Death following fiberoptic gastroscopy caused by pheochromocytoma.

    abstract::A 45-year-old woman was admitted to hospital for investigation of weight loss, sciatica and excess sweating. On examination, whe was found to have a tachycardia and the stigmata of von Recklinghausen's disease. Her investigations included a barium meal and gastroscopy. Following the gastroscopy, she developed ventricu...

    journal_title:Endoscopy

    pub_type: 杂志文章

    doi:10.1055/s-0028-1098490

    authors: Crowe J,Bottomley K,McCarthy CF

    更新日期:1977-03-01 00:00:00

  • Helicobacter pylori eradication: the best long-term prophylaxis for ulcer bleeding recurrence?

    abstract::Peptic ulcer is the most common cause of acute intestinal hemorrhage. Helicobacter pylori is now accepted as being a pathogenetic agent in chronic active gastritis, and is strongly associated with ulcer disease. Eradication of H. pylori reduces significantly the rate of ulcer recurrence. Preliminary data demonstrate t...

    journal_title:Endoscopy

    pub_type: 杂志文章,评审

    doi:10.1055/s-2007-1005771

    authors: Jaspersen D

    更新日期:1995-10-01 00:00:00

  • Massive subcutaneous emphysema following colonoscopy.

    abstract::A case of massive subcutaneous emphysema following colonoscopic polypectomy is reported. The incidence of colonic perforation following colonoscopy is 0.1% and may be intraperitoneal or retroperitoneal. Intraperitoneal perforation is usually immediately apparent and likely to require urgent surgical exploration. The d...

    journal_title:Endoscopy

    pub_type: 杂志文章

    doi:10.1055/s-2007-1018566

    authors: Humphreys F,Hewetson KA,Dellipiani AW

    更新日期:1984-07-01 00:00:00

  • Single- vs. double-balloon enteroscopy in small-bowel diagnostics: a randomized multicenter trial.

    abstract:BACKGROUND AND STUDY AIMS:Double-balloon enteroscopy (DBE) is the first choice endoscopic technique for small-bowel visualization. However, preparation and handling of the double-balloon enteroscope is complex. Recently, a single-balloon enteroscopy (SBE) system has been introduced as being a simplified, less-complex b...

    journal_title:Endoscopy

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1055/s-0030-1256247

    authors: Domagk D,Mensink P,Aktas H,Lenz P,Meister T,Luegering A,Ullerich H,Aabakken L,Heinecke A,Domschke W,Kuipers E,Bretthauer M

    更新日期:2011-06-01 00:00:00

  • Perforation of the oesophagus with an oblique--viewing endoscope in a patient with caustic stenosis.

    abstract::A case of accidental oesophageal perforation during endoscopy in an elderly woman with acute alimentary obstruction of a caustic stenosis is presented. This demonstrates the risks in routine use of oblique-viewing endoscopes, especially in oesophageal exploration. The lesion was successfully treated by internal splint...

    journal_title:Endoscopy

    pub_type: 杂志文章

    doi:10.1055/s-0028-1098297

    authors: Starlinger M,Dinstl K,Schiessel R

    更新日期:1978-08-01 00:00:00

  • Endoscopy and antiplatelet agents. European Society of Gastrointestinal Endoscopy (ESGE) Guideline.

    abstract::With the increasing use of antiplatelet agents (APA), their management during the periendoscopic period has become a more common and more difficult problem. The increase in use is due to the availability of new drugs and the widespread use of drug-eluting coronary stents. Acute coronary syndromes can occur when APA th...

    journal_title:Endoscopy

    pub_type: 杂志文章,实务指引

    doi:10.1055/s-0030-1256317

    authors: Boustière C,Veitch A,Vanbiervliet G,Bulois P,Deprez P,Laquiere A,Laugier R,Lesur G,Mosler P,Nalet B,Napoleon B,Rembacken B,Ajzenberg N,Collet JP,Baron T,Dumonceau JM,European Society of Gastrointestinal Endoscopy.

    更新日期:2011-05-01 00:00:00

  • Electronic endoscopy--the latest technology.

    abstract::At present, video endoscopic systems (VE) are available from four companies. We have had an opportunity to test these instruments in clinical practice. In principle, all the VE's are similar in that they employ charge coupling devices (CCD-chips) as image sensors, but they differ significantly in CCD chip technology a...

    journal_title:Endoscopy

    pub_type: 杂志文章

    doi:10.1055/s-2007-1018255

    authors: Classen M,Knyrim K,Seidlitz HK,Hagenmüller F

    更新日期:1987-05-01 00:00:00

  • Pancreatic duct stenosis mimicking a tumor due to an aberrant vessel.

    abstract::A case of a 74-year-old man is reported who had liver cirrhosis and a mass lesion in the left liver lobe. The search for a potential primary tumor showed a filiform duct stenosis in the pancreatic head on ERCP. The presumptive diagnosis of a pancreatic tumor with a liver metastasis was made. Due to the poor general co...

    journal_title:Endoscopy

    pub_type: 杂志文章

    doi:10.1055/s-2007-1008957

    authors: Born P,Barina W,Terfloth R,Fiebig A,Paul F

    更新日期:1994-02-01 00:00:00

  • Erosion and perforation of the biliary tree by plastic biliary endoprostheses.

    abstract::Biliary endoprostheses are increasingly used in the treatment of both benign and malignant pancreaticobiliary disorders. Common bile duct stones are a common clinical problem for which there now exist a range of treatment modalities. Official guidelines in the UK advocate the use of plastic biliary endoprostheses in t...

    journal_title:Endoscopy

    pub_type: 杂志文章

    doi:10.1055/s-0029-1244203

    authors: Sinha S,Wardle A,Kalidindi V,Banga N,Stoker DL

    更新日期:2010-09-01 00:00:00

  • Fine-needle endoscopic percutaneous gastrostomy.

    abstract::A procedure for percutaneous endoscopic gastrostomy is described. Under direct endoscopic control, the surgeon introduces, percutaneously, into the inflated stomach a 9 French Foley catheter through a special needle, which may then be opened for removal. After positioning, the terminal balloon of the Foley is inflated...

    journal_title:Endoscopy

    pub_type: 杂志文章

    doi:10.1055/s-2007-1018585

    authors: Negri G,Cosentino F,Spina GP

    更新日期:1984-11-01 00:00:00

  • Artificial intelligence for polyp detection during colonoscopy: a systematic review and meta-analysis.

    abstract:BACKGROUND: Artificial intelligence (AI)-based polyp detection systems are used during colonoscopy with the aim of increasing lesion detection and improving colonoscopy quality. PATIENTS AND METHODS: We performed a systematic review and meta-analysis of prospective trials to determine the value of AI-based polyp detec...

    journal_title:Endoscopy

    pub_type: 杂志文章

    doi:10.1055/a-1201-7165

    authors: Barua I,Vinsard DG,Jodal HC,Løberg M,Kalager M,Holme Ø,Misawa M,Bretthauer M,Mori Y

    更新日期:2020-06-17 00:00:00

  • Limitations of intraductal ultrasonography in differentiating between bile duct cancer in stage T1 and stage T2: in-vitro and in-vivo studies.

    abstract:BACKGROUND AND STUDY AIMS:We investigated whether intraductal ultrasonography (IDUS) could distinguish between stage T1 and T2 bile duct cancer. MATERIALS AND METHODS:In-vitro study. Resected bile duct specimens (n = 8) were immersed in a water tank and were pierced with straight pins to clarify the normal layer struc...

    journal_title:Endoscopy

    pub_type: 杂志文章

    doi:10.1055/s-2007-1004296

    authors: Tamada K,Kanai N,Ueno N,Ichiyama M,Tomiyama T,Wada S,Oohashi A,Nishizono T,Tano S,Aizawa T,Ido K,Kimura K

    更新日期:1997-10-01 00:00:00

  • Impact of double-balloon endoscopy on the diagnosis of jejunoileal involvement in primary intestinal follicular lymphomas: a case series.

    abstract::In recent years, primary gastrointestinal follicular lymphoma has been increasingly detected in the duodenum on esophagogastroduodenoscopy (EGD). Primary gastrointestinal follicular lymphomas are frequently distributed to multiple sites in the gastrointestinal tract. Therefore, investigation into the spread of follicu...

    journal_title:Endoscopy

    pub_type: 杂志文章

    doi:10.1055/s-0028-1119467

    authors: Higuchi N,Sumida Y,Nakamura K,Itaba S,Yoshinaga S,Mizutani T,Honda K,Taki K,Murao H,Ogino H,Kanayama K,Akiho H,Goto A,Segawa Y,Yao T,Takayanagi R

    更新日期:2009-02-01 00:00:00

  • Endoscopy innovations.

    abstract::Innovation everywhere for everybody - this is the way we can summarize the 2014 Digestive Disease Week, which was held in Chicago, Illinois, last May. Many sessions introduced new innovative materials and concepts. From the robot of the future to the simplest ideas, the congress was fertile and sometimes full of surpr...

    journal_title:Endoscopy

    pub_type: 杂志文章,评审

    doi:10.1055/s-0034-1377510

    authors: Vanbiervliet G,Gonzalez JM,Barthet M

    更新日期:2014-09-01 00:00:00

  • Endometrial pathological changes after Fallopian ring tubal ligation.

    abstract::Endometrial biopsy was used to study the luteal phase in patients with Fallopian ring (Yoon ring) tubal ligation. Luteal phase insufficiency was found in 9.3% of patients in the study group and in 3.4% of patients in the control group. THe differences are statistically not significant (p = 0.5). The patients with hist...

    journal_title:Endoscopy

    pub_type: 杂志文章

    doi:10.1055/s-2007-1021602

    authors: de Cristofaro D,Zancanari C,Fiaccavento S,Pezzoli C

    更新日期:1982-07-01 00:00:00

  • Favorable long-term outcomes of endoscopic submucosal dissection for locally recurrent early gastric cancer after endoscopic resection.

    abstract:BACKGROUND AND STUDY AIM:Close observation after noncurative endoscopic resection for early gastric cancer (EGC) is an acceptable option if a positive horizontal margin or piecemeal resection of differentiated-type adenocarcinoma is the only noncurative factor. When locally recurrent EGC is subsequently detected, endos...

    journal_title:Endoscopy

    pub_type: 杂志文章

    doi:10.1055/s-0033-1344332

    authors: Sekiguchi M,Suzuki H,Oda I,Abe S,Nonaka S,Yoshinaga S,Taniguchi H,Sekine S,Kushima R,Saito Y

    更新日期:2013-09-01 00:00:00

  • Diagnostic laparoscopy: an update.

    abstract::Diagnostic laparoscopy has been in use since the last century. Advances in technology, coupled with increasing evidence of enhanced outcomes following its use, have renewed interest in this modality. Diagnostic laparoscopy guides surgeons in preventing unnecessary laparotomies in settings of acute abdomen, oncologists...

    journal_title:Endoscopy

    pub_type: 杂志文章,评审

    doi:10.1055/s-2002-19847

    authors: Karnam US,Reddy KR

    更新日期:2002-02-01 00:00:00

  • Carcinoma of the ampulla of Vater: the endoscopic approach.

    abstract::Carcinoma of the ampulla of Vater is a rare tumor. Early and accurate diagnosis of carcinoma of the ampulla of Vater will lead to early treatment and subsequent better prognosis. Endoscopy and endoscopic retrograde cholangiopancreaticography (ERCP) has been shown to be one of the best diagnostic modalities. Furthermor...

    journal_title:Endoscopy

    pub_type: 杂志文章

    doi:10.1055/s-2007-1018180

    authors: Huibregtse K,Tytgat GN

    更新日期:1988-08-01 00:00:00

  • In vitro evaluation of the radial and axial force of self-expanding esophageal stents.

    abstract:BACKGROUND AND STUDY AIMS:Technological innovation in esophageal stent design has progressed over the past decades, but the association between the mechanical properties of stent design and clinical outcome is still poorly understood. In this study the radial force and axial force of currently available stent designs w...

    journal_title:Endoscopy

    pub_type: 杂志文章

    doi:10.1055/s-0033-1344985

    authors: Hirdes MM,Vleggaar FP,de Beule M,Siersema PD

    更新日期:2013-12-01 00:00:00

  • Diagnosis and management of iatrogenic endoscopic perforations: European Society of Gastrointestinal Endoscopy (ESGE) Position Statement - Update 2020.

    abstract::1:  ESGE recommends that each center implements a written policy regarding the management of iatrogenic perforations, including the definition of procedures that carry a higher risk of this complication. This policy should be shared with the radiologists and surgeons at each center. 2 : ESGE recommends that in the cas...

    journal_title:Endoscopy

    pub_type: 杂志文章

    doi:10.1055/a-1222-3191

    authors: Paspatis GA,Arvanitakis M,Dumonceau JM,Barthet M,Saunders B,Turino SY,Dhillon A,Fragaki M,Gonzalez JM,Repici A,van Wanrooij RLJ,van Hooft JE

    更新日期:2020-09-01 00:00:00

  • Prospective comparison between double-balloon enteroscopy and spiral enteroscopy.

    abstract:BACKGROUND AND STUDY AIMS:Push enteroscopy, balloon-guided, and single- and double-balloon enteroscopy (DBE) are now well established techniques in gastrointestinal endoscopy for small-bowel imaging and therapy. There are no published prospective studies comparing DBE with spiral enteroscopy and so the aim of the curre...

    journal_title:Endoscopy

    pub_type: 杂志文章

    doi:10.1055/s-0030-1255714

    authors: Frieling T,Heise J,Sassenrath W,Hülsdonk A,Kreysel C

    更新日期:2010-11-01 00:00:00

  • Safety and feasibility of laparoscopic and endoscopic cooperative surgery for duodenal neoplasm: A retrospective multicenter study.

    abstract:BACKGROUND: A delayed perforation can often occur after endoscopic treatment for duodenal neoplasms and may be fatal due to leakage of pancreatic and bile juices. We aimed to evaluate the feasibility and safety of laparoscopic and endoscopic cooperative surgery for duodenal neoplasms (D-LECS) in a multicenter, retrospe...

    journal_title:Endoscopy

    pub_type: 杂志文章

    doi:10.1055/a-1327-5939

    authors: Nunobe S,Ri M,Yamazaki K,Uraoka M,Ohata K,Kitazono I,Terashima M,Yamagata Y,Tanabe S,Abe N,Tsuji T,Niimi K,Kawakubo H,Tsukada T,Kitashiro S,Ishizuka N,Hiki N

    更新日期:2020-12-02 00:00:00

  • Colon polyps and cancer.

    abstract::Several important studies on screening for colorectal neoplasia were published in 1998-99, including average-risk as well as high-risk groups, and different strategies such as endoscopy, fecal occult blood tests, and other more specific markers of neoplasia. Some of these studies included the use of interventions othe...

    journal_title:Endoscopy

    pub_type: 杂志文章,评审

    doi:10.1055/s-2000-141

    authors: Kronborg O

    更新日期:2000-02-01 00:00:00