Lumbar myelography with iohexol and metrizamide: a comparative multicenter prospective study.

Abstract:

:Diagnostic quality of radiographs and adverse reactions associated with the use of metrizamide and iohexol as contrast agents in lumbar myelography were compared in a prospective randomized double blind study in 350 patients at seven centers. The contrast media were administered in comparable volumes at a concentration of 180 mg I per ml. Overall quality of radiographic visualization was graded good or excellent in 95% of 175 metrizamide studies and in 98% of 175 iohexol studies. Ninety-three patients examined using metrizamide (53%) and 130 patients examined using iohexol (74%) experienced no discomfort during or after myelography. Postmyelographic headache was associated with 38% of metrizamide examinations and 21% of iohexol examinations. Nausea and vomiting were also more common with metrizamide. Five patients examined using metrizamide (3%) experienced transient confusion and disorientation following lumbar myelography. No such reactions were observed following iohexol myelography.

journal_name

Radiology

journal_title

Radiology

authors

Kieffer SA,Binet EF,Davis DO,Gabrielsen TO,Kido DK,Latchaw RE,Turski PA,Shaw DD

doi

10.1148/radiology.151.3.6371890

subject

Has Abstract

pub_date

1984-06-01 00:00:00

pages

665-70

issue

3

eissn

0033-8419

issn

1527-1315

journal_volume

151

pub_type

临床试验,杂志文章,随机对照试验
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