Modulation by interferons of HLA antigen, high-molecular-weight melanoma associated antigen, and intercellular adhesion molecule 1 expression by cultured melanoma cells with different metastatic potential.

abstract：:CBLC (CBL proto-oncogene c) belongs to the CBL protein family, which has E3 ubiquitin ligase activity toward activated receptor tyrosine kinases. CBLC is frequently upregulated in non-small cell lung cancer (NSCLC), yet very little is known about the functions of CBLC in tumorigenesis. Here we show that CBLC is an epi...

journal_title：Cancer research

authors： Hong SY,Kao YR,Lee TC,Wu CW

更新日期：2018-09-01 00:00:00

abstract：:Preexisting and acquired resistance to epidermal growth factor receptor (EGFR) inhibitors limits their clinical usefulness in patients with advanced non-small cell lung cancer (NSCLC). This study characterizes the efficacy and mechanisms of the combination of gefitinib or erlotinib with OSU-03012, a celecoxib-derived ...

journal_title：Cancer research

authors： Wang YC,Kulp SK,Wang D,Yang CC,Sargeant AM,Hung JH,Kashida Y,Yamaguchi M,Chang GD,Chen CS

更新日期：2008-04-15 00:00:00

abstract：:Sézary syndrome is the leukemic form of cutaneous T-cell lymphoma characterized by circulating neoplastic CD4+ T-cells. Although peripheral blood mononuclear cells from patients with Sézary syndrome have been shown to respond poorly to mitogens, we found that mitogen-activated peripheral blood mononuclear cells from f...

journal_title：Cancer research

authors： Abrams JT,Ghosh SK,DeFreitas E

更新日期：1993-11-15 00:00:00

abstract：:The ability of the in vitro sister chromatid exchange (SCE) assay to predict in vivo tumor drug sensitivity was investigated using a spontaneous hepatocarcinoma in C3Hf/Kam mice and 3 chemotherapeutic agents: melphalan; cis-platinum; and 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU). For hepatocarcinoma cells grown in m...

journal_title：Cancer research

authors： Tofilon PJ,Basic I,Milas L

更新日期：1985-05-01 00:00:00

abstract：:FGF2 signaling in glioblastoma induces resistance to radiotherapy, so targeting FGF2/FGFR pathways might offer a rational strategy for tumor radiosensitization. To investigate this possibility, we evaluated a specific role for FGFR1 in glioblastoma radioresistance as modeled by U87 and LN18 glioblastomas in mouse xeno...

journal_title：Cancer research

authors： Gouazé-Andersson V,Delmas C,Taurand M,Martinez-Gala J,Evrard S,Mazoyer S,Toulas C,Cohen-Jonathan-Moyal E

更新日期：2016-05-15 00:00:00

abstract：:High-resolution magic angle spinning proton (HRMAS 1H) magnetic resonance spectroscopy produces well-resolved spectra of metabolites from intact tissue specimens. Here we report the results of a preliminary study of 19 human brain tumors obtained by applying this method. Among these 19 cases were 2 low-grade astrocyto...

journal_title：Cancer research

authors： Cheng LL,Chang IW,Louis DN,Gonzalez RG

更新日期：1998-05-01 00:00:00

abstract：:Oncogene activation and loss of tumor suppressor genes are known to play a role in tumor initiation as well as its progression. The potential roles of these genes in perturbation of genome stability has become a major interest. To better understand the relationship between expression of an oncogene and genetic instabi...

journal_title：Cancer research

authors： Wani MA,Xu X,Stambrook PJ

更新日期：1994-05-01 00:00:00

abstract：:Human platelet lysate was shown to contain growth-promoting activity for four well-established malignant cell lines. Platelet lysate was able to support their cell proliferation without plasma or serum, indicating that platelets contained "survival factor" as well as mitogenic factor for these tumor cells. The growth-...

journal_title：Cancer research

authors： Hara Y,Steiner M,Baldini MG

更新日期：1980-04-01 00:00:00

abstract：:Molecular docking is a standard computational approach to predict binding modes of protein-ligand complexes by exploring alternative orientations and conformations of the ligand (i.e., by exploring ligand flexibility). Docking tools are largely used for virtual screening of small drug-like molecules, but their accurac...

journal_title：Cancer research

authors： Antunes DA,Moll M,Devaurs D,Jackson KR,Lizée G,Kavraki LE

更新日期：2017-11-01 00:00:00

abstract：:Antisense DNA has shown an ability to target specific oncogene transcripts and inhibit their expression in cells, but the degree to which sustained treatment can suppress total levels of an oncogenic product and alter tumorigenesis in vivo remains to be determined. In this study, NIH-3T3 cells transformed by the activ...

journal_title：Cancer research

authors： Gray GD,Hernandez OM,Hebel D,Root M,Pow-Sang JM,Wickstrom E

更新日期：1993-02-01 00:00:00

abstract：:Uptake of actinomycin D (AD) was characterized in Ehrlich ascites tumor cells in vitro. The time course of uptake consists of an initial component that represents a unidirectional flux of AD into the cells, following which the net uptake rate falls to achieve a velocity that is constant over a 45-min interval of obser...

journal_title：Cancer research

authors： Bowen D,Goldman ID

更新日期：1975-11-01 00:00:00

abstract：:Potent luteinizing hormone-releasing hormone analogues are known to cause regression of hormone-dependent mammary tumors. We have observed that high and long-lasting serum levels of a potent luteinizing hormone-releasing hormone analogue [desglycyl10-(D-leucyl6) luteinizing hormone-releasing hormone ethylamide, leupro...

journal_title：Cancer research

authors： Okada H,Sakura Y,Kawaji H,Yashiki T,Mima H

更新日期：1983-04-01 00:00:00

abstract：:BAG-1 is a multifunctional protein that interacts with a wide range of cellular targets. There is accumulating evidence that overexpression of BAG-1 may play an important role in breast cancer; however, the functional consequences of BAG-1 expression and its mechanism of action in breast cancer cells have not been stu...

journal_title：Cancer research

authors： Townsend PA,Cutress RI,Sharp A,Brimmell M,Packham G

更新日期：2003-07-15 00:00:00

abstract：:Mitotic and labeling indices of bone marrow tumor cells were determined from patients with disseminated neuroblastoma. Although pretreatment values were variable, the median indices indicated that only a small proportion of tumor cells were proliferating. The pretreatment indices could not be correlated with presentin...

journal_title：Cancer research

authors： Hayes FA,Green AA,Mauer AM

更新日期：1977-10-01 00:00:00

abstract：:Patients with metastatic melanoma or multiple myeloma have a dismal prognosis because these aggressive malignancies resist conventional treatment. A promising new oncologic approach uses molecularly targeted therapeutics that overcomes apoptotic resistance and, at the same time, achieves tumor selectivity. The unexpec...

journal_title：Cancer research

authors： Qin JZ,Ziffra J,Stennett L,Bodner B,Bonish BK,Chaturvedi V,Bennett F,Pollock PM,Trent JM,Hendrix MJ,Rizzo P,Miele L,Nickoloff BJ

更新日期：2005-07-15 00:00:00

abstract：:The carcinogenicities of a choline deficient L-amino acid defined (CDAA) diet and a semipurified choline deficient diet were comparatively examined. A total of 60 male Fischer 344 rats, 6 weeks old, were divided into 5 experimental groups each consisting of 12 rats. Group 1 received the CDAA diet chronically to the en...

journal_title：Cancer research

authors： Nakae D,Yoshiji H,Mizumoto Y,Horiguchi K,Shiraiwa K,Tamura K,Denda A,Konishi Y

更新日期：1992-09-15 00:00:00

abstract：:Whole chromosomal instability (CIN), manifested as unequal chromosome distribution during cell division, is a distinguishing feature of most cancer types. CIN is generally considered to drive tumorigenesis, but a threshold level exists whereby further increases in CIN frequency in fact hinder tumor growth. While this ...

journal_title：Cancer research

authors： Lee HS,Lee NC,Kouprina N,Kim JH,Kagansky A,Bates S,Trepel JB,Pommier Y,Sackett D,Larionov V

更新日期：2016-02-15 00:00:00

abstract：:As previously reported for natural killer (NK) cells of normal individuals, prior incubation of peripheral blood lymphocytes from cancer patients with human normal serum or monomeric immunoglobulin G reduced their subsequent capacity to kill K562 target cells in a 4-h 51Cr release assay. The NK activity of such treate...

journal_title：Cancer research

authors： Pislarasu M,Oproiu A,Taranu D,Herberman RB,Sulica A

更新日期：1988-05-01 00:00:00

abstract：:A model for cell detachment which may influence metastasis in vivo is described involving the transfer of hamster melanoma cells from aggregates of those tumor cells to hamster fibroblast aggregates. The aggregates were made by the spontaneous association of cultured cells. Tumor and fibroblast aggregates were then in...

journal_title：Cancer research

authors： Umbreit JN,Erbe RW

更新日期：1979-06-01 00:00:00

abstract：:Identification of specific chromosomal aberrations in transformed mesothelial cells is an important step in elucidating the mechanism of transformation of these cells which are targets for occupational and environmental carcinogens, such as asbestos fibers. Cytogenetic analysis of normal rat mesothelial cell lines rev...

journal_title：Cancer research

authors： Funaki K,Everitt J,Bermudez E,Walker C

更新日期：1991-08-01 00:00:00

abstract：:Thirty-seven consecutive patients with germ cell cancers (34 testicular, three extragonadal) and elevated serum levels of alpha-fetoprotein (AFP) and/or human chorionic gonadotropin (HCG) were treated with vinblastine, bleomycin, and cis-diamminedichloroplatinum induction chemotherapy. The AFP and/or HCG normalized in...

journal_title：Cancer research

authors： Vogelzang NJ,Lange PH,Goldman A,Vessela RH,Fraley EE,Kennedy BJ

更新日期：1982-11-01 00:00:00

abstract：:We analyzed the immunohistochemical expression of three epitopes of the tumor-associated glycoprotein 72 (TAG-72) in whole cross-sections of primary colorectal carcinomas and in regional lymph node metastases using monoclonal antibodies (MAbs) B72.3, CC-49, and CC-83, which recognize distinct carbohydrate antigenic de...

journal_title：Cancer research

authors： Muraro R,Frati L,Bei R,Ficari F,Valli C,French D,Mammarella S,Caramia F,Fegiz G,Mariani-Costantini R

更新日期：1991-10-01 00:00:00

abstract：:Age-adjusted mortality rates for non-Hodgkin's lymphoma in counties of the contiguous United States were examined by sex and race during 1950 to 1975 and were correlated through 1969 with demographic and industrial data. Mortality was consistently elevated in counties with large populations, especially in those with h...

journal_title：Cancer research

authors： Cantor KP,Fraumeni JF Jr

更新日期：1980-08-01 00:00:00

abstract：:Tumor development relies upon essential contributions from the tumor microenvironment and host immune alterations. These contributions may inform the plasma proteome in a manner that could be exploited for cancer diagnosis and prognosis. In this study, we employed a systems biology approach to characterize the plasma ...

journal_title：Cancer research

authors： Pitteri SJ,Kelly-Spratt KS,Gurley KE,Kennedy J,Buson TB,Chin A,Wang H,Zhang Q,Wong CH,Chodosh LA,Nelson PS,Hanash SM,Kemp CJ

更新日期：2011-08-01 00:00:00

abstract：:The molecular pathways driving mesenchymal glioblastoma (GBM) are still not well understood. We report here that truncated glioma-associated oncogene homolog 1 (tGLI1) is a tumor-specific transcription factor that facilitates GBM growth, is enriched in the mesenchymal subtype of GBM and glioma stem cells (GSC), and pr...

journal_title：Cancer research

authors： Rimkus TK,Carpenter RL,Sirkisoon S,Zhu D,Pasche BC,Chan MD,Lesser GJ,Tatter SB,Watabe K,Debinski W,Lo HW

更新日期：2018-05-15 00:00:00

abstract：:We have shown previously that the transduction of a number of human tumor cell lines with an adenovirus (AV1Y28) expressing a single-chain antibody fragment (scFv) directed against Ras proteins results in radiosensitization. Because Ras is involved in the regulation of a number of transcription factors, we have determ...

journal_title：Cancer research

authors： Russell JS,Raju U,Gumin GJ,Lang FF,Wilson DR,Huet T,Tofilon PJ

更新日期：2002-04-15 00:00:00

abstract：:Cell-cycle inhibition has yet to offer a generally effective approach to cancer treatment, but a full evaluation of different combinations of cell-cycle inhibitors has not been evaluated. Cyclin A2, a core component of the cell cycle, is often aberrantly expressed in cancer where it may impact cell proliferation. In t...

journal_title：Cancer research

authors： Gopinathan L,Tan SL,Padmakumar VC,Coppola V,Tessarollo L,Kaldis P

更新日期：2014-07-15 00:00:00

abstract：:The role of the NKG2D immunoreceptor and its ligands in antitumor immune response is incompletely understood. Here, we report that effector immune cells infiltrating ovarian carcinoma are mostly CD8+ lymphocytes lacking CD28 but expressing the NKG2D costimulatory receptor. Human ovarian carcinoma expresses the novel N...

journal_title：Cancer research

authors： Conejo-Garcia JR,Benencia F,Courreges MC,Gimotty PA,Khang E,Buckanovich RJ,Frauwirth KA,Zhang L,Katsaros D,Thompson CB,Levine B,Coukos G

更新日期：2004-03-15 00:00:00

abstract：:The present study was designed to determine whether alterations in host metabolism associated with progressive tumor growth were a result of the anorexia frequently observed with cancer or could be attributed to other direct tumor effects. Rates of tyrosine flux, oxidation, and incorporation into protein, as well as f...

journal_title：Cancer research

authors： Kawamura I,Moldawer LL,Keenan RA,Batist G,Bothe A Jr,Bistrian BR,Blackburn GL

更新日期：1982-03-01 00:00:00

abstract：:Cellular interaction with the extracellular milieu plays a significant role in normal biological and pathologic processes. Excessive degradation of basement membrane matrix by proteolytic enzymes is a hallmark of tumor invasion and metastasis, and aspartyl proteinase cathepsin D is implicated as a major contributor to...

journal_title：Cancer research

authors： Khalkhali-Ellis Z,Hendrix MJ

更新日期：2007-04-15 00:00:00