Atenolol in human plasma and breast milk.

Abstract:

:To assess the problem of continuing atenolol in a breast-feeding mother with hypertension associated with thyrotoxicosis, studies were performed to determine simultaneous plasma and breast milk concentrations of atenolol after a single dose of 50 mg and on continuous therapy of varying weekly dosages. Peak atenolol concentrations in breast milk were 3.6 times higher than simultaneous plasma atenolol concentrations after single-dose administration and 2.9 times higher after continuous-dose administration. A single plasma concentration obtained in the infant following a peak level feeding was less than 10 ng/ml. Although it would seem unlikely that the amount of atenolol excretion in breast milk should warrant interruption of breast-feeding because of maternal medication with ordinary doses, the infant should be evaluated for signs of beta-blockade.

journal_name

Obstet Gynecol

authors

White WB,Andreoli JW,Wong SH,Cohn RD

subject

Has Abstract

pub_date

1984-03-01 00:00:00

pages

42S-44S

issue

3 Suppl

eissn

0029-7844

issn

1873-233X

journal_volume

63

pub_type

杂志文章
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    authors: Chmel H,Hamdy M

    更新日期:1984-06-01 00:00:00

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    authors: Brinton LA,Nasca PC,Mallin K,Baptiste MS,Wilbanks GD,Richart RM

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    pub_type: 杂志文章,meta分析

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    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

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    pub_type: 杂志文章

    doi:

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    doi:

    authors: Goudas VT,Wasty F,Pardanani B,Ying YK

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  • DNA content as a prognostic factor in endometrial carcinoma.

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    doi:

    authors: Newbury R,Schuerch C,Goodspeed N,Fanning J,Glidewell O,Evans M

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  • Massive blood transfusion during hospitalization for delivery in New York State, 1998-2007.

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