Megadose corticosteroid therapy following experimental traumatic spinal injury.

Abstract:

:Corticosteroids are frequently used in the treatment of spinal trauma, although neither experimental nor clinical evidence to support their use is persuasive. Recently there have been claims that extremely high doses ("megadoses") of corticosteroids (equivalent to 15 to 30 mg/kg of methylprednisolone) improve neurological recovery compared to results with traditional steroid doses. The authors have compared the effect of megadose dexamethasone and methylprednisolone therapy to that of saline treatment following traumatic cervical spinal injury in the cat. During 6 weeks postinjury, neurological recovery did not differ significantly in corticosteroid-treated and saline-treated animals. Moreover, histopathological changes in the spinal cord were similar in methylprednisolone- and saline-treated cats. Corticosteroid-treated animals had a higher mortality rate than did control animals, with the predominant cause of death being neurogenic pulmonary edema. It is concluded that megadose corticosteroid treatment does not improve neurological recovery in this experimental model of spinal injury, and is associated with increased mortality.

journal_name

J Neurosurg

journal_title

Journal of neurosurgery

authors

Faden AI,Jacobs TP,Patrick DH,Smith MT

doi

10.3171/jns.1984.60.4.0712

subject

Has Abstract

pub_date

1984-04-01 00:00:00

pages

712-7

issue

4

eissn

0022-3085

issn

1933-0693

journal_volume

60

pub_type

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