Pathophysiology of periventricular tissue changes with raised CSF pressure in cats.

Abstract:

:Intraventricular pressure (IVP) is increased in the early stages of acute hydrocephalus. Pressure falls, however, when compensatory routes for cerebrospinal fluid (CSF) absorption develop. In order to better understand the pathophysiology of acute hydrocephalus, the authors performed ventriculocisternal perfusions on adult cats with outflow pressures maintained at either -5, 20, or 40 cm H2O. Cerebral blood flow (CBF) was determined by the iodoantipyrine method. Penetration of an extracellular marker, horseradish peroxidase (HRP), was visualized histologically. Capillary transfer of radiolabeled molecules from CSF to blood was measured by steady-state tissue clearance. Increased IVP had several effects: 1) significant reduction in mean CBF in the periventricular white matter; 2) penetration of the HRP into deep white matter; and 3) prolongation of steady-state tissue clearance half-time for (14C)-ethylene glycol in the caudate nucleus. Reduced blood flow to periventricular white matter and impaired molecular clearance in the caudate nucleus may contribute to the clinical symptoms in acute hydrocephalus.

journal_name

J Neurosurg

journal_title

Journal of neurosurgery

authors

Rosenberg GA,Saland L,Kyner WT

doi

10.3171/jns.1983.59.4.0606

subject

Has Abstract

pub_date

1983-10-01 00:00:00

pages

606-11

issue

4

eissn

0022-3085

issn

1933-0693

journal_volume

59

pub_type

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