Prostaglandin metabolism in experimental cerebral vasospasm.

Abstract:

:Experimental cerebral vasospasm was produced in the canine basilar artery by an intracisternal injection of fresh autogenous arterial blood, and prostaglandins generated in spastic and nonspastic arteries were assessed by thin-layer chromatography. Prostaglandins synthesized in normal arteries were 6-keto-prostaglandin (PG)F1 alpha, PGF2 alpha, PGE2, and PGD2; 6-keto-PGF1 alpha was the most abundant prostaglandin. The study of platelet aggregation suggested that prostacyclin (PGI2)-like activity was manufactured by the normal basilar artery. At 5 minutes after the intracisternal blood injection, no significant changes were evident in syntheses of prostaglandins generated by spastic artery. However, PGE2 synthesis was significantly increased in spastic artery 2 days after the intracisternal blood injection, and 6-keto-PGF1 alpha and PGF2 alpha synthesis and PGE2 synthesis were significantly decreased and increased, respectively, in spastic artery 6 days after the intracisternal blood injection. No significant changes were found in syntheses of 6-keto-PGF1 alpha, PGF2 alpha, and PGE2 manufactured by nonspastic arteries at any stage. Formation of thromboxane B2 was not detected in normal, spastic, or nonspastic arteries.

journal_name

J Neurosurg

journal_title

Journal of neurosurgery

authors

Maeda Y,Tani E,Miyamoto T

doi

10.3171/jns.1981.55.5.0779

subject

Has Abstract

pub_date

1981-11-01 00:00:00

pages

779-85

issue

5

eissn

0022-3085

issn

1933-0693

journal_volume

55

pub_type

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