Abstract：
OBJECTIVE:To investigate the effects of 4-month treatment of medroxyprogesterone acetate (MPA) and Diane-35 on the clinical and biochemical features of hyperandrogenism and quality of life of adolescent girls with polycystic ovarian syndrome (PCOS). DESIGN:A prospective, randomized, cross-over study. SETTING:An accredited pediatric and adolescent gynecology clinic of a university-affiliated tertiary hospital. PARTICIPANTS:76 adolescents girls aged 14 to 19 years old with PCOS were recruited from July 2007 to July 2010. INTERVENTIONS:Girls were randomized into 2 groups. Group 1 received oral MPA for 4 months, followed by a washout period of 4 months, and then Diane-35 for another 4 months. Group 2 received the same combination but in the reverse order. MAIN OUTCOME MEASURES:Clinical and biochemical features of hyperandrogenism and quality of life were assessed. RESULTS:There was no significant difference between the 2 groups at baseline. No significant difference was found in the clinical and biochemical parameters of hyperandrogenism before and after treatment with MPA. Significant reduction of the acne score, LH/FSH ratio, and testosterone level was seen after taking Diane-35. Hirsutism was also improved but it did not reach statistical significant. When comparing post-MPA and post-Diane-35, the post-Diane-35 group had significantly improved acne score and LH/FSH ratio. No significant difference was found on quality of life between both groups after treatment. CONCLUSION:Diane-35 may be a more suitable treatment option in adolescent girls diagnosed with PCOS when compared to MPA.
journal_name
J Pediatr Adolesc Gynecoljournal_title
Journal of pediatric and adolescent gynecologyauthors
Chung JP,Yiu AK,Chung TK,Chan SSdoi
10.1016/j.jpag.2013.09.011subject
Has Abstractpub_date
2014-06-01 00:00:00pages
166-71issue
3eissn
1083-3188issn
1873-4332pii
S1083-3188(13)00297-0journal_volume
27pub_type
杂志文章,随机对照试验abstract：STUDY OBJECTIVE:Long-acting reversible contraceptive (LARC) methods are the most effective forms of reversible contraception but adolescents often opt for other, less effective methods. In this study we explored how adolescents viewed LARC as an innovation to be adopted or rejected, and how their assessment of innovati...
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abstract：:In this article we review the existing fertility preservation options for women diagnosed with Turner syndrome and provide practical guidelines for the practitioner. Turner syndrome is the most common sex chromosome abnormality in women, occurring in approximately 1 in 2500 live births. Women with Turner syndrome are ...
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journal_title：Journal of pediatric and adolescent gynecology
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